Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathways

Vascular Pharmacology

Volumn 58, Issue 1-2, 2013, Pages 118-126

  Tong, Bei ^a   Lu, Dan ^a   Wei, Zhifeng ^a   Wang, Ting ^a   Xia, Yufeng ^a   Dai, Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Gleditsioside B; Human umbilical vein endothelial cell; Migration; Signaling pathway

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; GLEDITSIOSIDE B; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; SAPONIN DERIVATIVE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INACTIVATION; FRUIT; GLEDITSIA; GLEDITSIA SINENSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ZYMOGRAPHY;

ANGIOGENESIS INHIBITORS; BLOTTING, WESTERN; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 2; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FRUIT; GENE EXPRESSION REGULATION; GLEDITSIA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84871713000     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.09.006     Document Type: Article

References (49)

1. Bian Q., Wang Y.J., Shi Q. Progress in research on focal adhesion kinase signal transduction and cross-talk. Zhong Xi Yi Jie He Xue Bao 2005, 3:495-497.
2. Brew K., Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim. Biophys. Acta 2010, 1803:55-71.
3. Chen J.S., Huang X.H., Wang Q., Chen X.L., Fu X.H., Tan H.X., et al. FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin. Exp. Metastasis 2010, 27:71-82.
4. Chow L.M., Tang J.C., Teo I.T., Chui C.H., Lau F.Y., Leung T.W., et al. Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines. Chemotherapy 2002, 48:303-308.
5. Chow L.M., Chui C.H., Tang J.C., Lau F.Y., Yau M.Y., Cheng G.Y., et al. Anti-angiogenic potential of Gleditsia sinensis fruit extract. Int. J. Mol. Med. 2003, 12:269-273.
6. Chui C.H., Tang J.C., Lau F.Y., Teo I.T., Yau M.Y., Wong R.S., et al. Gleditsia sinensis fruit extract induced growth inhibition involves basic fibroblast growth factor and nitric oxide. Int. J. Mol. Med. 2004, 13:169-173.
7. Cohen L.A., Guan J.L. Mechanisms of focal adhesion kinase regulation. Curr. Cancer Drug Targets 2005, 5:629-643.
8. Coussens L.M., Fingleton B., Matrisian L.M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002, 295:2387-2392.
9. Dai Y., Chan Y.P., Chu L.M., Bu P.P. Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis. Biol. Pharm. Bull. 2002, 25:1179-1182.
10. Dai J., Peng L., Fan K., Wang H., Wei R., Ji G., et al. Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene 2009, 28:3412-3422.
11. Deregibus M.C., Buttiglieri S., Russo S., Bussolati B., Camussi G. CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis. J. Biol. Chem. 2003, 278:18008-18014.
12. Graves J.D., Campbell J.S., Krebs E.G. Protein serine/threonine kinases of the MAPK cascade. Ann. N. Y. Acad. Sci. 1995, 766:320-343.
13. Hou L.F., Dai Y., Wang C., Xia Y.F. Amelioration of collagen-induced arthritis in mice by a saponin fraction from Gleditsia sinensis. Pharm. Biol. 2006, 44:651-656.
14. Ischenko I., Guba M., Yezhelyev M., Papyan A., Schmid G., Green T., et al. Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer. Angiogenesis 2007, 10:167-182.
15. Jaffe E.A., Nachman R.L., Becker C.G., Miniker C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973, 52:2745-2756.
16. Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat. Rev. Cancer 2003, 3:422-433.
17. Kornberg L.J., Grant M.B. Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK. Microvasc. Res. 2007, 73:157-162.
18. Kosmidou I., Xagorari A., Roussos C., Papapetropoulos A. Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/AKT pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001, 280:L585-L592.
19. Lamalice L., Le Boeuf F., Huot J. Endothelial cell migration during angiogenesis. Circ. Res. 2007, 100:782-794.
20. Lauffenburger D.A., Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 1996, 84:359-369.
21. Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1α-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 2001, 21:3995-4004.
22. Li S., Huang N.F., Hsu S. Mechanotransduction in endothelial cell migration. J. Cell. Biochem. 2005, 96:1110-1126.
23. Licht T., Tsirulnikov L., Reuveni H., Yarnitzky T., Ben-Sasson S.A. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood 2003, 102:2099-2107.
24. Liekens S., De Clercq E., Neyts J. Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 2001, 61:253-270.
25. Lin K.T., Lien J.C., Chung C.H., Kuo S.C., Huang T.F. A novel compound, NP-184, inhibits the vascular endothelial growth factor induced angiogenesis. Eur. J. Pharmacol. 2010, 630:53-60.
26. Lu D., Xia YF., Tong B., Zhang C., Pan R., Xu H., Yang X., Dai Y., 2012. In vitro Anti-angiogenesis effects and active constituents of the saponin fraction from Gleditsia sinensis. Integr. Cancer Ther. In press.
27. Namkoong S., Lee S.J., Kim C.K., Kim Y.M., Chung H.T., Lee H., et al. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp. Mol. Med. 2005, 37:588-600.
28. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 1995, 9:484-496.
29. Nugent M.A., Iozzo R.V. Fibroblast growth factor-2. Int. J. Biochem. Cell Biol. 2000, 32:115-120.
30. Overall C.M., Kleifeld O. Towards third generation matrix metalloproteinase inhibitors for cancer therapy. Br. J. Cancer 2006, 94:941-946.
31. Page-McCaw A., Ewald A.J., Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 2007, 8:221-233.
32. Pak K.C., Lam K.Y., Law S., Tang J.C. The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. Int. J. Mol. Med. 2009, 23:121-129.
33. Pan R., Dai Y., Gao X.H., Lu D., Xia Y.F. Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways. Vascul. Pharmacol. 2011, 54:18-28.
34. Pan R., Gao X.H., Lu D., Xu X., Xia Y.F., Dai Y. Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action. Int. Immunopharmacol. 2011, 11:2007-2016.
35. Park H.Y., Kwon H.M., Lim H.J., Hong B.K., Lee J.Y., Park B.E., et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp. Mol. Med. 2001, 33:95-102.
36. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 2003, 116:1409-1416.
37. Presta M., Dell'Era P., Mitola S., Moroni E., Ronca R., Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 2005, 16:159-178.
38. Rebaï O., Le Petit-Thevenin J., Bruneau N., Lombardo D., Vérine A. In vitro angiogenic effects of pancreatic bile salt-dependent lipase. Arterioscler. Thromb. Vasc. Biol. 2005, 25:359-364.
39. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., et al. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
40. Roomi M.W., Ivanov V., Kalinovsky T., Niedzwecki A., Rath M. Anti-angiogenic effects of a nutrient mixture on human umbilical vein endothelial cells. Oncol. Rep. 2005, 14:1399-1404.
41. Schaller M.D. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim. Biophys. Acta 2001, 1540:1-21.
42. Schlaepfer D.D., Mitra S.K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 2004, 14:92-101.
43. Siesser P.M., Hanks S.K. The signaling and biological implications of FAK overexpression in cancer. Clin. Cancer Res. 2006, 12:3233-3237.
44. Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., et al. Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. Int. J. Mol. Med. 2007, 19:953-960.
45. Tsang M., Dawid I.B. Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci. STKE 2004, pe17.
46. Wu J.C., Yan H.C., Chen W.T., Chen W.H., Wang C.J., Chi Y.C., et al. JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC. Exp Cell Res. 2008, 314:421-429.
47. Xia Y.F., Gao Z.Z., Dai Y., Wang Q. Analysis of bioactive saponins in Fructus Gleditsiae abnormalis and Fructus Gleditsiae sinensis by LC-ELSD. Chromatographia 2009, 70:1361-1366.
48. Zachary I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am. J. Physiol. Cell Physiol. 2001, 280:C1375-C1386.
49. Zhao X., Guan J.L. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv. Drug Deliv. Rev. 2011, 63:610-615.