Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 9, 2012, Pages 5780-5787

  Onouchi, Hiromi ^a   Ishii, Takamasa ^a   Miyazawa, Masaki ^a   Uchino, Yuichi ^b   Yasuda, Kayo ^a   Hartman, Phil S ^c   Kawai, Kenji ^a   Tsubota, Kazuo ^b   Ishii, Naoaki ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATALASE; SUPEROXIDE; 8-HYDROXY-2'-DEOXYGUANOSINE; CAENORHABDITIS ELEGANS PROTEIN; DEOXYGUANOSINE; DRUG DERIVATIVE; MEV 1 PROTEIN, C ELEGANS; MEV-1 PROTEIN, C ELEGANS; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA STROMA; DISEASE COURSE; ELECTRON MICROSCOPY; ELECTRON TRANSPORT; ENUCLEATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; TRANSGENIC MOUSE; WESTERN BLOTTING; AGING; ANIMAL; C57BL MOUSE; CELL COUNT; CORNEA DISEASE; CORNEA ENDOTHELIUM; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

AGING; ANIMALS; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS PROTEINS; CATALASE; CELL COUNT; CORNEAL DISEASES; DEOXYGUANOSINE; ELECTRON TRANSPORT COMPLEX II; ENDOTHELIUM, CORNEAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; OXIDATIVE STRESS; PROTEIN CARBONYLATION; SUCCINATE DEHYDROGENASE; SUPEROXIDES; TETRACYCLINE;

EID: 84871695366     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-9573     Document Type: Article

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