Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 1, 2011, Pages 427-433

  Kubota, Miyuki ^a   Shimmura, Shigeto ^a   Kubota, Shunsuke ^a   Miyashita, Hideyuki ^a   Kato, Naoko ^a   Noda, Kousuke ^b   Ozawa, Yoko ^a   Usui, Tomohiko ^c   Ishida, Susumu ^b   Umezawa, Kazuo ^d   Kurihara, Toshihide ^a   Tsubota, Kazuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CD31 ANTIGEN; COPPER ZINC SUPEROXIDE DISMUTASE; DEHYDROXYMETHYLEPOXYQUINOMICIN; HYDROETHIDINE; HYDROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SODIUM HYDROXIDE; VASCULOTROPIN; ANTIOXIDANT; BENZAMIDE DERIVATIVE; CCL2 PROTEIN, MOUSE; CYCLOHEXANONE DERIVATIVE; DEUTERIUM OXIDE; SUPEROXIDE DISMUTASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CAUSTIC BURN; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA NEOVASCULARIZATION; DISEASE MODEL; DOWN REGULATION; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; UPREGULATION; WILD TYPE; ANIMAL; BLINDNESS; CHEMICAL BURN; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE BURN; FLUORESCENCE MICROSCOPY; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE MUTANT; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BENZAMIDES; BLINDNESS; BURNS, CHEMICAL; CHEMOKINE CCL2; CORNEAL NEOVASCULARIZATION; CYCLOHEXANONES; DEUTERIUM OXIDE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE BURNS; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM HYDROXIDE; SUPEROXIDE DISMUTASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79952025016     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6167     Document Type: Article

References (28)

1. Chang JH, Gabison EE, Kato T, Azar DT. Corneal neovascularization. Curr Opin Ophthalmol. 2001;12:242-249.
2. Huang AJ, Li DQ, Li CH, Shang TY, Hernandez E. Modulation of corneal vascularization. Ocul Surf. 2005;3:S190-S193.
3. BenEzra D, Griffin BW, Maftzir G, Sharif NA, Clark AF. Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization. Invest Ophthalmol Vis Sci. 1997;38:1954-1962.
4. Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol. 1998;43:245-269.
5. Saika S, Miyamoto T, Yamanaka O, et al. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factorkappaB, in treatment of corneal alkali burns in mice. Am J Pathol. 2005;166:1393-1403.
6. Mochimaru H, Usui T, Yaguchi T, et al. Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci. 2008; 49:2172-2177.
7. Bock F, Onderka J, Dietrich T, et al. Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci. 2007;48:2545-2552.
8. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-247.
9. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683.
10. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13:688-694.
11. Berent-Spillson A, Russell JW. Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration. J Neurochem. 2007; 101:342-354.
12. Sasaki M, Ozawa Y, Kurihara T, et al. Neuroprotective effect of an antioxidant, lutein, during retinal inflammation. Invest Ophthalmol Vis Sci. 2009;50:1433-1439.
13. Nakao S, Hata Y, Miura M, et al. Dexamethasone inhibits interleukin- 1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis. Am J Pathol. 2007;171:1058-1065.
14. Watanabe T, Higuchi K, Hamaguchi M, et al. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2004;287:G919-G928.
15. Papathanassiou M, Theodossiadis PG, Liarakos VS, Rouvas A, Giamarellos-Bourboulis EJ, Vergados IA. Inhibition of corneal neovascularization by subconjunctival bevacizumab in an animal model. Am J Ophthalmol. 2008;145:424-431.
16. Yoeruek E, Ziemssen F, Henke-Fahle S, et al. Safety, penetration and efficacy of topically applied bevacizumab: evaluation of eyedrops in corneal neovascularization after chemical burn. Acta Ophthalmol. 2008;86:322-328.
17. Watanabe M, Dewan MZ, Okamura T, et al. A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo. Int J Cancer. 2005;114:32-38.
18. Pueyo ME, Gonzalez W, Nicoletti A, Savoie F, Arnal JF, Michel JB. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Arterioscler Thromb Vasc Biol. 2000;20:645-651.
19. Morigi M, Macconi D, Zoja C, et al. Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol. 2002;13: 1179-1189.
20. Brauer RW, Way RO. Relative narcotic potencies of hydrogen, helium, nitrogen, and their mixtures. J Appl Physiol. 1970;29: 23-31.
21. Cai J, Kang Z, Liu WW, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 2008;441: 167-172.
22. Buchholz BM, Kaczorowski DJ, Sugimoto R, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008;8:2015-2024.
23. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anticancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009;64:753-761.
24. Jones NP, Hayward JM, Khaw PT, Claoue CM, Elkington AR. Function of an ophthalmic "accident and emergency" department: results of a six month survey. Br Med J (Clin Res Ed). 1986;292: 188-190.
25. Pfister RR. Chemical injuries of the eye. Ophthalmology. 1983;90: 1246-1253.
26. Vernon SA. Analysis of all new cases seen in a busy regional centre ophthalmic casualty department during 24-week period. J R Soc Med. 1983;76:279-282.
27. Macdonald EC, Cauchi PA, Azuara-Blanco A, Foot B. Surveillance of severe chemical corneal injuries in the UK. Br J Ophthalmol. 2009;93:1177-1180.
28. Yao YF, Zhang B, Zhou P, Jiang JK. Autologous limbal grafting combined with deep lamellar keratoplasty in unilateral eye with severe chemical or thermal burn at late stage. Ophthalmology. 2002;109:2011-2017.