Nuclear Import of UBL-Domain Protein Mdy2 Is Required for Heat-Induced Stress Response in Saccharomyces cerevisiae

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Arhzaouy, Khalid ^a,b   Ramezani Rad, Massoud ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PROTEIN MDY2; PROTEIN PAB1; UNCLASSIFIED DRUG;

ARTICLE; CELL GRANULE; CONTROLLED STUDY; HEAT STRESS; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; CARRIER PROTEINS; CYTOPLASMIC GRANULES; HEAT-SHOCK RESPONSE; HUMANS; MODELS, BIOLOGICAL; NUCLEAR EXPORT SIGNALS; NUCLEAR LOCALIZATION SIGNALS; ORGANISMS, GENETICALLY MODIFIED; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; UBIQUITIN; UBIQUITINS;

SACCHAROMYCES CEREVISIAE;

EID: 84871675341     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052956     Document Type: Article

References (43)

1. Jentsch S, Pyrowolakis G, (2000) Ubiquitin and its kin: how close are the family ties? Trends Cell Biol 10: 335-342.
2. Hu Z, Potthoff B, Hollenberg CP, Ramezani-Rad M, (2006) Mdy2, a ubiquitin-like (UBL)-domain protein, is required for efficient mating in Saccharomyces cerevisiae. J Cell Sci 119: 326-338.
3. Saeki Y, Saitoh A, Toh-e A, Yokosawa H, (2002) Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitin-dependent proteolysis. Biochem Biophys Res Commun 293: 986-992.
4. Cohnen A, Bielig H, Hollenberg CP, Hu Z, Ramezani-Rad M, (2010) The yeast ubiquitin-like domain protein Mdy2 is required for microtubule-directed nuclear migration and localizes to cytoplasmic granules in response to heat stress. Cytoskeleton (Hoboken) 67: 635-649.
5. Iwanejko L, Smith KN, Loeillet S, Nicolas A, Fabre F, (1999) Disruption and functional analysis of six ORFs on chromosome XV: YOL117w, YOL115w (TRF4), YOL114c, YOL112w (MSB4), YOL111c and YOL072w. Yeast 15: 1529-1539.
6. Toniolo D, Martini G, Migeon BR, Dono R, (1988) Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA. Embo J 7: 401-406.
7. Battle A, Jonikas MC, Walter P, Weissman JS, Koller D, (2010) Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol 6: 379.
8. Bozkurt G, Stjepanovic G, Vilardi F, Amlacher S, Wild K, et al. (2009) Structural insights into tail-anchored protein binding and membrane insertion by Get3. Proc Natl Acad Sci U S A 106: 21131-21136.
9. Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, et al. (2010) The genetic landscape of a cell. Science 327: 425-431.
10. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323: 1693-1697.
11. Wang F, Brown EC, Mak G, Zhuang J, Denic V, (2010) A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum. Mol Cell 40: 159-171.
12. Chook YM, Blobel G, (2001) Karyopherins and nuclear import. Curr Opin Struct Biol 11: 703-715.
13. Gorlich D, Kutay U, (1999) Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 15: 607-660.
14. Lange A, Mills RE, Devine SE, Corbett AH, (2008) A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1. J Biol Chem 283: 12926-12934.
15. Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, et al. (2007) Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282: 5101-5105.
16. Mattaj IW, Englmeier L, (1998) Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 67: 265-306.
17. Dingwall C, Laskey RA, (1991) Nuclear targeting sequences-a consensus? Trends Biochem Sci 16: 478-481.
18. Kalderon D, Richardson WD, Markham AF, Smith AE, (1984) Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 311: 33-38.
19. Robbins J, Dilworth SM, Laskey RA, Dingwall C, (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64: 615-623.
20. Dong X, Biswas A, Suel KE, Jackson LK, Martinez R, et al. (2009) Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature 458: 1136-1141.
21. Tran EJ, Bolger TA, Wente SR, (2007) SnapShot: nuclear transport. Cell 131: 420.
22. Hegde RS, Keenan RJ, (2011) Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol 12: 787-798.
23. Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL, (2010) Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting. Structure 18: 897-902.
24. Chartron JW, Suloway CJ, Zaslaver M, Clemons WM Jr, (2010) Structural characterization of the Get4/Get5 complex and its interaction with Get3. Proc Natl Acad Sci U S A 107: 12127-12132.
25. Chartron JW, VanderVelde DG, Rao M, Clemons WM, (2012) Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex. Journal of Biological Chemistry 287: 8310-8317.
26. la Cour T, Kiemer L, Molgaard A, Gupta R, Skriver K, et al. (2004) Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel 17: 527-536.
27. Chang YW, Chuang YC, Ho YC, Cheng MY, Sun YJ, et al. (2010) Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. J Biol Chem 285: 9962-9970.
28. Chartron JW, Gonzalez GM, Clemons WM Jr, (2011) A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex. J Biol Chem 286: 34325-34334.
29. Buchan JR, Yoon JH, Parker R, (2011) Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae. J Cell Sci 124: 228-239.
30. Grousl T, Ivanov P, Frydlova I, Vasicova P, Janda F, et al. (2009) Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae. J Cell Sci 122: 2078-2088.
31. Brengues M, Parker R, (2007) Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae. Mol Biol Cell 18: 2592-2602.
32. Hoyle NP, Castelli LM, Campbell SG, Holmes LE, Ashe MP, (2007) Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. J Cell Biol 179: 65-74.
33. Brune C, Munchel SE, Fischer N, Podtelejnikov AV, Weis K, (2005) Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. Rna 11: 517-531.
34. Fleischer TC, Weaver CM, McAfee KJ, Jennings JL, Link AJ, (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20: 1294-1307.
35. Liou ST, Cheng MY, Wang C, (2007) SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae. Cell Stress Chaperones 12: 59-70.
36. Sowa ME, Bennett EJ, Gygi SP, Harper JW, (2009) Defining the human deubiquitinating enzyme interaction landscape. Cell 138: 389-403.
37. Wang Q, Liu Y, Soetandyo N, Baek K, Hegde R, et al. (2011) A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol Cell 42: 758-770.
38. Anderson P, Kedersha N, (2006) RNA granules. J Cell Biol 172: 803-808.
39. Kedersha N, Chen S, Gilks N, Li W, Miller IJ, et al. (2002) Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell 13: 195-210.
40. Buchan JR, Parker R, (2009) Eukaryotic stress granules: the ins and outs of translation. Mol Cell 36: 932-941.
41. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, et al. (2005) Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol 169: 871-884.
42. Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, Takekawa M, (2008) Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol 10: 1324-1332.
43. Jansen G, Wu C, Schade B, Thomas DY, Whiteway M, (2005) Drag&Drop cloning in yeast. Gene 344: 43-51.