A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 12926-12934

  Lange, Allison ^a   Mills, Ryan E ^a   Devine, Scott E ^a   Corbett, Anita H ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; YEAST;

BINDING PROTEINS; HYDROPHOBIC RESIDUES; IMPORTINS; IN-VIVO; KARYOPHERINS; NUCLEAR IMPORTS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR LOCALIZATIONS; NUCLEAR TARGETING; ORTHOLOG; PROTEIN FUNCTIONS; PROTEOME; RECEPTOR BINDINGS; SACCHAROMYCES CEREVISIAE; TERMINAL PORTIONS;

PROBABILITY DENSITY FUNCTION;

FUNGAL PROTEIN; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; HORSERADISH PEROXIDASE; HYBRID PROTEIN; KARYOPHERIN; KARYOPHERIN 104; MESSENGER RNA; PROTEIN HRP1; PROTEIN NAB2; PROTEOME; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; HRP1 PROTEIN, S CEREVISIAE; KAP104 PROTEIN, S CEREVISIAE; NAB2 PROTEIN, S CEREVISIAE; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BIOINFORMATICS; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HYDROPHOBICITY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; YEAST; ACTIVE TRANSPORT; CELL NUCLEUS; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

SACCHAROMYCES CEREVISIAE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; CELL NUCLEUS; KARYOPHERINS; MOLECULAR SEQUENCE DATA; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NUCLEAR LOCALIZATION SIGNALS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 45149113882     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800898200     Document Type: Article

References (32)

1. Fahrenkrog, B., and Aebi, U. (2003) Nat. Rev. Mol. Cell Biol. 4, 757-766
2. Stoffler, D., Fahrenkrog, B., and Aebi, U. (1999) Curr. Opin. Cell Biol. 11, 391-401
3. Allen, T. D., Cronshaw, J. M., Bagley, S., Kiseleva, E., and Goldberg, M. W. (2000) J. Cell Sci. 113, 1651-1659
4. Paine, P. L., Moore, L. C., and Horowitz, S. B. (1975) Nature 254, 109-114
5. Bonner, W. M. (1978) Protein Migration and Accumulation in Nuclei, Academic Press, New York
6. Mosammaparast, N., and Pemberton, L. F. (2004) Trends Cell Biol. 14, 547-556
7. Cook, A., Bono, F., Jinek, M., and Conti, E. (2007) Annu. Rev. Biochem. 76, 647-671
8. Quimby, B. B., and Dasso, M. (2003) Curr Opin. Cell Biol. 15, 338-344
9. Lee, S. J., Matsuura, Y., Liu, S. M., and Stewart, M. (2005) Nature 435, 693-696
10. Görlich, D., Panté, N., Kutay, U., Aebi, U., and Bischoff, F. R. (1996)EMBO J. 15, 5584-5594
11. Chook, Y. M., and Blobel, G. Nature 399, 230-237
12. Lange, A., Mills, R. E., Lange, C. J., Stewart, M., Devine, S. E., and Corbett, A. H. (2007) J. Biol. Chem. 282, 5101-5105
13. Lee, S., Sekimoto, T., Yamashita, E., Nagoshi, E., Nakagawa, A., Imamoto, N., Yoshimura, M., Sakai, H., Chong, K., Tsukihara, T., and Yoneda, Y. (2003) Science 302, 1571-1575
14. Cingolani, G., Petosa, C., Weis, K., and Müller, C. W. (1999) Nature 399, 221-229
15. Cingolani, G., Bednenko, J., Gillespie, M. T., and Gerace, L. (2002) Mol. Cell 10, 1345-1353
16. Lee, B. J., Cansizoglu, A. E., Süel, K. E., Louis, T. H., Zhang, Z., and Chook, Y. M. (2006) Cell 126, 543-558
17. Aitchison, J. D., Blobel, G., and Rout, M. P. (1996) Science 274, 624-627
18. Lee, D. C., and Aitchison, J. D. (1999) J. Biol. Chem. 274, 29031-29037
19. Truant, R., Fridell, R. A., Benson, R. E., Bogerd, H., and Cullen, B. R. (1998) Mol. Cell. Biol. 18, 1449-1458
20. Kessler, M. M., Henry, M. F., Shen, E., Zhao, J., Gross, S., Silver, P. A., and Moore, C. L. (1997) Genes Dev. 11, 2545-2556
21. Hector, R. E., Nykamp, K. R., Dheur, S., Anderson, J. T., Non, P. J., Urbinati, C. R., Wilson, S. M., Minvielle-Sebastia, L., and Swanson, M. S. (2002) EMBO J. 21, 1800-1810
22. Green, D. M., Marfatia, K. A., Crafton, E. B., Zhang, X., Cheng, X., and Corbett, A. H. (2002) J. Biol. Chem. 277, 7752-7760
23. Adams, A., Gottschling, D. E., Kaiser, C. A., and Stearns, T. (1997) Methods in Yeast Genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
24. Sambrook, J., and Russell, D. (2001) Molecular Cloning: A Laboratory Manual, 3rd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
25. Leslie, D. M., Zhang, W., Timney, B. L., Chait, B. T., Rout, M. P., Wozniak, R. W., and Aitchison, J. D. (2004) Mol. Cell. Biol. 24, 8487-8503
26. Boeke, J. D., Trueheart, J., Natsoulis, G., and Fink, G. R. (1987) Methods Enzymol. 154, 164-175
27. Gattiker, A., Gasteiger, E., and Bairoch, A. (2002) Appl. Bioinformatics 1, 107-108
28. Benson, D. A., Karsch-Mizrachi, I., Lipman, D. J., Ostell, J., and Wheeler, D. L. (2007) Nucleic Acids Res. 35, D21-D25
29. Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., and O'Shea, E. K. (2003) Nature 425, 686-691
30. Winston, F., Dollard, C., and Ricupero-Hovasse, S. L. (1995) Yeast 11, 53-55
31. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
32. Hodel, A. E., Harreman, M. T., Pulliam, K. F., Harben, M. E., Holmes, J. S., Hodel, M. R., Berland, K. M., and Corbett, A. H. (2006) J. Biol. Chem. 281, 23545-23556