Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N -methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 11042-11051

  Fujinaga, Masayuki ^a   Yamasaki, Tomoteru ^a,b   Maeda, Jun ^a   Yui, Joji ^a   Xie, Lin ^a   Nagai, Yuji ^a   Nengaki, Nobuki ^a,c   Hatori, Akiko ^a   Kumata, Katsushi ^a   Kawamura, Kazunori ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c 141 0032   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; CARBON 11; FLUORINE 18; METABOTROPIC RECEPTOR 1; N [4 [6 (ISOPROPYLAMINO)PYRIMIDIN 4 YL] 1,3 THIAZOL 2 YL] N METHYL 4 METHYLBENZAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CEREBELLUM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; THALAMUS;

ANIMALS; AUTORADIOGRAPHY; BENZAMIDES; BRAIN; CARBON RADIOISOTOPES; MACACA MULATTA; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84871645476     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301597s     Document Type: Article

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