Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice

Journal of Neurochemistry

Volumn 124, Issue 2, 2013, Pages 241-249

  Nakajima, Mitsunari ^a   Mori, Hisamichi ^a   Nishikawa, Chisa ^a   Tsuruta, Momoko ^a   Okuyama, Satoshi ^a   Furukawa, Yoshiko ^a  

^a MATSUYAMA UNIVERSITY   (Japan)

Author keywords

deleter mice; interpeduncular nucleus; neural crest; psychiatric disorder; wnt1 cre

Indexed keywords

CHOLINE ACETYLTRANSFERASE; CRE RECOMBINASE; TRANSCRIPTION FACTOR GAL4; VESICULAR GLUTAMATE TRANSPORTER 2; WNT1 PROTEIN;

ABNORMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BRAIN REGION; CONTROLLED STUDY; EPITHALAMUS; FEMALE; HABENULA; HABENULOINTERPEDUNCULAR TRACT; HISTOPATHOLOGY; INTERPEDUNCULAR NUCLEUS; LOCOMOTION; MALE; MEMORY DISORDER; MENTAL DISEASE; NERVE TRACT; NESTING; NEURAL CREST; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SCHIZOPHRENIA; SOCIAL BEHAVIOR; SPATIAL MEMORY; TEGMENTUM; TRANSGENIC MOUSE;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; HABENULA; MALE; MAZE LEARNING; MENTAL DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NESTING BEHAVIOR; NEURAL CREST; NEURAL PATHWAYS; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOPHRENIA; TEGMENTUM MESENCEPHALI; TRANSCRIPTION FACTORS; WNT1 PROTEIN;

ANIMALIA; MUS; MUS MUSCULUS; VERTEBRATA;

EID: 84871620525     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12085     Document Type: Article

References (42)

1. Alarcõn M., Abrahams B. S., Stone J. L., et al,. (2008) Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am. J. Hum. Genet. 82, 150-159.
2. Alkuraya F. S., Lin A. E., Irons M. B., and, Kimonis V. E., (2005) Fryns syndrome with Hirschsprung disease: support for possible neural crest involvement. Am. J. Med. Genet. A 132A, 226-230.
3. Bach A., Lallemand Y., Nicola M. A., Ramos C., Mathis L., Maufras M., and, Robert B., (2003) Msx1 is required for dorsal diencephalon patterning. Development 130, 4025-4036.
4. Ballard T. M., Pauly-Evers M., Higgins G. A., Ouagazzal A. M., Mutel V., Borroni E., Kemp J. A., Bluethmann H., and, Kew J. N., (2002) Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J. Neurosci. 22, 6713-6723.
5. Canuso C. M., and, Pandina G., (2007) Gender and schizophrenia. Psychopharmacol. Bull. 40, 178-190.
6. Caputo A., Ghiringhelli L., Dieci M., Giobbio G. M., Tenconi F., Ferrari L., Gimosti E., Prato K., and, Vita A., (1998) Epithalamus calcifications in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 248, 272-276.
7. Craddock N., O'Donovan M. C., and, Owen M. J., (2005) The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 42, 193-204.
8. Creuzet S. E., (2009) Neural crest contribution to forebrain development. Semin. Cell Dev. Biol. 20, 751-759.
9. Dahlström A., and, Fuxe K., (1964) Localization of monoamines in the lower brain stem. Experientia 20, 398-399.
10. Danielian P. S., Muccino D., Rowitch D. H., Michael S. K., and, McMahon A. P., (1998) Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323-1326.
11. Dietrich P., Shanmugasundaram R., Shuyu E., and, Dragatsis I., (2009) Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum. Mol. Genet. 18, 142-150.
12. Geschwind D. H., (2008) Autism: many genes, common pathways? Cell 135, 391-395.
13. Geschwind D. H., and, Levitt P., (2007) Autism spectrum disorders: developmental disconnection syndromes. Curr. Opin. Neurobiol. 17, 103-111.
14. Gilbert S. F,. (1949) Developmental biology, the 8th ed., Sinauer Associates, Inc., Sunderland, MA.
15. Hiroi N., Zhu H., Lee M., Funke B., Arai M., Itokawa M., Kucherlapati R., Morrow B., Sawamura T., and, Agatsuma S., (2005) A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice. Proc. Natl Acad. Sci. USA 102, 19132-19137.
16. Humphreys R., Zheng W., Prince L. S., Qu X., Brown C., Loomes K., Huppert S. S., Baldwin S., and, Goudy S., (2012) Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum. Mol. Genet. 21, 1374-1383.
17. Jaaro-Peled H., (2009) Gene models of schizophrenia: DISC1 mouse models. Prog. Brain Res. 179, 75-86.
18. Jiang X., Rowitch D. H., Soriano P., McMahon A. P., and, Sucov H. M., (2000) Fate of the mammalian cardiac neural crest. Development 127, 1607-1616.
19. Jiang X., Iseki S., Maxson R. E., Sucov H. M., and, Morriss-Kay G. M., (2002) Tissue origins and interactions in the mammalian skull vault. Dev. Biol. 241, 106-116.
20. Kapur S., Mizrahi R., and, Li M., (2005) From dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis. Schizophr. Res. 79, 59-68.
21. Kirkbride J. B., Errazuriz A., Croudace T. J., Morgan C., Jackson D., Boydell J., Murray R. M., and, Jones P. B., (2012) Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses. PLoS ONE 7, e31660.
22. Lecourtier L., and, Kelly P. H., (2005) Bilateral lesions of the habenula induce attentional disturbances in rats. Neuropsychopharmacology 30, 484-496.
23. Lecourtier L., Neijt H. C., and, Kelly P. H., (2004) Habenula lesions cause impaired cognitive performance in rats: implications for schizophrenia. Eur. J. Neurosci. 19, 2551-2560.
24. Lee J. Y., Ristow M., Lin X., White M. F., Magnuson M. A., and, Hennighausen L., (2006) RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J. Biol. Chem. 281, 2649-2653.
25. Lister R. G., (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92, 180-185.
26. Mao X., Fujiwara Y., and, Orkin S. H., (1999) Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl Acad. Sci. USA 96, 5037-5042.
27. Miyakawa T., Leiter L. M., Gerber D. J., Gainetdinov R. R., Sotnikova T. D., Zeng H., Caron M. G., and, Tonegawa S., (2003) Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc. Natl Acad. Sci. USA 100, 8987-8992.
28. Ranft K., Dobrowolny H., Krell D., Bielau H., Bogerts B., and, Bernstein H. G., (2010) Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia. Psychol. Med. 40, 557-567.
29. Rapoport J. L., Addington A. M., Frangou S., and, Psych M. R., (2005) The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 10, 434-449.
30. Rowitch D. H., S-Jacques B., Lee S. M., Flax J. D., Snyder E. Y., and, McMahon A. P., (1999) Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci. 19, 8954-8965.
31. Rünker A. E., O'Tuathaigh C., Dunleavy M., Morris D. W., Little G. E., Corvin A. P., Gill M., Henshall D. C., Waddington J. L., and, Mitchell K. J., (2011) Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology. PLoS ONE 6, e26488.
32. Sandyk R., (1992) Pineal and habenula calcification in schizophrenia. Int. J. Neurosci. 67, 19-30.
33. Schmeisser M. J., Ey E., Wegener S., et al,. (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature 486, 256-260.
34. Schmidt-Supprian M., and, Rajewsky K., (2007) Vagaries of conditional gene targeting. Nat. Immunol. 8, 665-668.
35. Shprintzen R. J., Higgins A. M., Antshel K., Fremont W., Roizen N., and, Kates W., (2005) Velo-cardio-facial syndrome. Curr. Opin. Pediatr. 17, 725-730.
36. Stefansson H., Sigurdsson E., Steinthorsdottir V., et al,. (2002) Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892.
37. Tabuchi K., Blundell J., Etherton M. R., Hammer R. E., Liu X., Powell C. M., and, Südhof T. C., (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318, 71-76.
38. Utikal J., Maherali N., Kulalert W., and, Hochedlinger K., (2009) Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J. Cell Sci. 122 (Pt 19), 3502-3510.
39. Volkmar F. R., Szatmari P., and, Sparrow S. S., (1993) Sex differences in pervasive developmental disorders. J. Autism Dev. Disord. 23, 579-591.
40. White T., and, Hilgetag C. C., (2011) Gyrification and neural connectivity in schizophrenia. Dev. Psychopathol. 23, 339-352.
41. Won H., Lee H. R., Gee H. Y., et al,. (2012) Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486, 261-265.
42. Yuan T., Wang Y., Pao L., Anderson S. M., and, Gu H., (2011) Lactation defect in a widely used MMTV-Cre transgenic line of mice. PLoS ONE 6, e19233.