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Volumn 4, Issue 1, 2008, Pages 33-43

A potential therapeutic strategy for diabetes and its complications in the form of co-encapsulated antioxidant nanoparticles (NanoCAPs) of ellagic acid and coenzyme Q10: Preparation and evaluation in streptozotocin induced diabetic rats

Author keywords

Antioxidants; Coenzyme Q10; Diabetes; Ellagic acid; Nanoparticles; Oxidative damage

Indexed keywords

ACIDS; GLUCOSE; RATS; SUGAR (SUCROSE);

EID: 57749176217     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (41)
  • 1
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications
    • K. G. M. M. Alberti and P. Z. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Diabet. Med. 15, 539 (1998).
    • (1998) Diabet. Med , vol.15 , pp. 539
    • Alberti, K.G.M.M.1    Zimmet, P.Z.2
  • 2
    • 0027253061 scopus 로고
    • Long-term complications of diabetes mellitus
    • D. M. Nathan, Long-term complications of diabetes mellitus. New Engl. J. Med. 328, 1676 (1993).
    • (1993) New Engl. J. Med , vol.328 , pp. 1676
    • Nathan, D.M.1
  • 3
    • 0027370108 scopus 로고
    • DCCT Research Group, The effect of intensive therapy of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus
    • DCCT Research Group, The effect of intensive therapy of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus. New Engl. J. Med. 329, 977 (1993).
    • (1993) New Engl. J. Med , vol.329 , pp. 977
  • 4
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
    • DCCT Research Group
    • DCCT Research Group, Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. New Engl. J. Med. 342, 381 (2000).
    • (2000) New Engl. J. Med , vol.342 , pp. 381
  • 5
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Research Group
    • UK Prospective Diabetes Research Group, Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352, 854 (1998).
    • (1998) Lancet , vol.352 , pp. 854
  • 6
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Research Group
    • UK Prospective Diabetes Research Group, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837 (1998).
    • (1998) Lancet , vol.352 , pp. 837
  • 7
    • 0034641568 scopus 로고    scopus 로고
    • Prospective observational study
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes UKPDS 35
    • I. M. Stratton, A. I. Adler, H. A. Neil, D. R. Matthews, S. E. Manley, C. A. Cull, D. Hadden, R. C. Turner, and R. R. Holman, Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. Brit. Med. J. 321, 405 (2000).
    • (2000) Brit. Med. J , vol.321 , pp. 405
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3    Matthews, D.R.4    Manley, S.E.5    Cull, C.A.6    Hadden, D.7    Turner, R.C.8    Holman, R.R.9
  • 8
    • 11844259382 scopus 로고    scopus 로고
    • Standards of medical care in diabetes
    • American Diabetes Association, s
    • American Diabetes Association, Standards of medical care in diabetes. Diabetes Care 28, s4 (2006).
    • (2006) Diabetes Care , vol.28 , pp. 4
  • 9
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • M. Brownlee, Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813 (2001).
    • (2001) Nature , vol.414 , pp. 813
    • Brownlee, M.1
  • 10
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • T. Nishikawa, D. Edelstein, and X. Du, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787 (2000).
    • (2000) Nature , vol.404 , pp. 787
    • Nishikawa, T.1    Edelstein, D.2    Du, X.3
  • 11
    • 0025142898 scopus 로고
    • Natural history of b-cell dysfunction in NIDDM
    • J. L. Leahy, Natural history of b-cell dysfunction in NIDDM. Diabetes Care 13, 992 (1990).
    • (1990) Diabetes Care , vol.13 , pp. 992
    • Leahy, J.L.1
  • 12
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • M. Tiedge, S. Lortz, J. Drinkgern, and S. Lenzen, Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46, 1733 (1997).
    • (1997) Diabetes , vol.46 , pp. 1733
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 13
    • 0041589462 scopus 로고    scopus 로고
    • Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats
    • M. Vessal, M. Hemmati, and M. Vasie, Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats. Comp. Biochem. Physiol. C 135, 357 (2003).
    • (2003) Comp. Biochem. Physiol. C , vol.135 , pp. 357
    • Vessal, M.1    Hemmati, M.2    Vasie, M.3
  • 14
    • 11144328863 scopus 로고    scopus 로고
    • O. Coskun, M. Kanter, A. Korkmaz, S. Oter, and Quercetin, A flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol. Res. 51, 117 (2005).
    • O. Coskun, M. Kanter, A. Korkmaz, S. Oter, and Quercetin, A flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol. Res. 51, 117 (2005).
  • 17
    • 21644485299 scopus 로고    scopus 로고
    • Effects of ellagic acid and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid on sorbitol accumulation in vitro and in vivo
    • H. Ueda, K. Kawanishi, and M. Moriyasu, Effects of ellagic acid and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid on sorbitol accumulation in vitro and in vivo. Biol. Pharm. Bull. 27, 1584 (2004).
    • (2004) Biol. Pharm. Bull , vol.27 , pp. 1584
    • Ueda, H.1    Kawanishi, K.2    Moriyasu, M.3
  • 20
    • 0007913520 scopus 로고    scopus 로고
    • 10 on the antioxidation status the basic parameters of metabolism of fats and sugars in diabetic patients
    • 10 on the antioxidation status the basic parameters of metabolism of fats and sugars in diabetic patients. Slovensky Lekar 12, 35 (1997).
    • (1997) Slovensky Lekar , vol.12 , pp. 35
    • Gvozdjakova, A.1    Kucharska, J.2    Braunova, Z.3    Kolesar, P.4
  • 21
    • 0025327523 scopus 로고
    • Ubiquinol-10 is an effective lipid soluble antioxidant at physiological concentrations
    • B. Frei, M. C. Kim, and B. N. Ames, Ubiquinol-10 is an effective lipid soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. USA 87, 4879 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4879
    • Frei, B.1    Kim, M.C.2    Ames, B.N.3
  • 22
  • 23
    • 27944449998 scopus 로고    scopus 로고
    • Design of biodegradable nanoparticles: A novel approach to encapsulating poorly soluble phytochemical ellagic acid
    • I. Bala, V. Bhardwaj, S. Hariharan, J. Sitterberg, U. Bakowsky, and M. N. V. R. Kumar, Design of biodegradable nanoparticles: A novel approach to encapsulating poorly soluble phytochemical ellagic acid. Nanotechnology 16, 2819 (2005).
    • (2005) Nanotechnology , vol.16 , pp. 2819
    • Bala, I.1    Bhardwaj, V.2    Hariharan, S.3    Sitterberg, J.4    Bakowsky, U.5    Kumar, M.N.V.R.6
  • 24
    • 30344446947 scopus 로고    scopus 로고
    • Analytical methods for assay of ellagic acid and its solubility studies
    • I. Bala, V. Bhardwaj, S. Hariharan, and M. N. V. R. Kumar, Analytical methods for assay of ellagic acid and its solubility studies. J. Pharm. Biomed. Anal. 40, 206 (2005).
    • (2005) J. Pharm. Biomed. Anal , vol.40 , pp. 206
    • Bala, I.1    Bhardwaj, V.2    Hariharan, S.3    Kumar, M.N.V.R.4
  • 25
    • 0042762851 scopus 로고    scopus 로고
    • Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA
    • A. C. Whitley, G. D. Stoner, M. V. Darby, and T. Walle, Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA. Biochem. Pharmacol. 66, 907 (2003).
    • (2003) Biochem. Pharmacol , vol.66 , pp. 907
    • Whitley, A.C.1    Stoner, G.D.2    Darby, M.V.3    Walle, T.4
  • 26
    • 33645099245 scopus 로고    scopus 로고
    • 10: Absorption, tissue uptake, metabolism and pharmacokinetics
    • 10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res. 40, 445 (2006).
    • (2006) Free Radic. Res , vol.40 , pp. 445
    • Bhagavan, H.N.1    Chopra, R.K.2
  • 28
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • H. Ohkawa, N. Ohishi, and K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351 (1979).
    • (1979) Anal. Biochem , vol.95 , pp. 351
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 30
    • 0033864129 scopus 로고    scopus 로고
    • 10 and vitamin E alter the status of these compounds in rat tissues and mitochondria
    • 10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J. Nutr. 130, 2343 (2000).
    • (2000) J. Nutr , vol.130 , pp. 2343
    • Ibrahim, W.H.I.1    Bhagavan, H.N.2    Chopra, R.K.3    Chow, C.K.4
  • 31
  • 32
    • 0029787326 scopus 로고    scopus 로고
    • Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat organs and cells
    • Y. Zhang, M. Turunen, and E. L. Appelkvist, Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat organs and cells. J. Nutr. 126, 2089 (1996).
    • (1996) J. Nutr , vol.126 , pp. 2089
    • Zhang, Y.1    Turunen, M.2    Appelkvist, E.L.3
  • 33
    • 0023125383 scopus 로고
    • Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration
    • R. W. Teel, Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration. Cancer Lett. 34, 165 ( 1987).
    • (1987) Cancer Lett , vol.34 , pp. 165
    • Teel, R.W.1
  • 34
    • 0023941674 scopus 로고
    • Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage
    • R. W. Teel and R. M. Martin, Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage. Xenobiotica 18, 883 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 883
    • Teel, R.W.1    Martin, R.M.2
  • 35
    • 0032402219 scopus 로고    scopus 로고
    • Evaluation of nano- and microparticle uptake by the gastrointestinal ttract
    • F. Delie, Evaluation of nano- and microparticle uptake by the gastrointestinal ttract. Adv. Drug Del. Rev. 34, 221 (1998).
    • (1998) Adv. Drug Del. Rev , vol.34 , pp. 221
    • Delie, F.1
  • 36
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
    • N. Hussain, V. Jaitley, and A. T. Florence, Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Del. Rev. 50, 107 (2001).
    • (2001) Adv. Drug Del. Rev , vol.50 , pp. 107
    • Hussain, N.1    Jaitley, V.2    Florence, A.T.3
  • 38
    • 34147150618 scopus 로고    scopus 로고
    • Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo
    • Estradiol loaded PLGA nanoparticles for oral administration
    • G. Mittal, D. K. Sahana, V. Bhardwaj, and M. N. V. Ravi Kumar, Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J. Control. Rel. 119, 77 (2007).
    • (2007) J. Control. Rel , vol.119 , pp. 77
    • Mittal, G.1    Sahana, D.K.2    Bhardwaj, V.3    Ravi Kumar, M.N.V.4
  • 40
    • 29944435940 scopus 로고    scopus 로고
    • 10 on catalase activity and other antioxidant parameters in streptazocin induced diabetic rats
    • 10 on catalase activity and other antioxidant parameters in streptazocin induced diabetic rats. Biol. Trace Element Res. 109, 25 (2006).
    • (2006) Biol. Trace Element Res , vol.109 , pp. 25
    • Modi, K.1    Satani, D.D.2    Goyal, R.K.3    Bhatt, P.A.4
  • 41
    • 0021352868 scopus 로고
    • Effects of epicatechin on rat islets of Langerhans
    • C. S. Hii and S. L. Howell, Effects of epicatechin on rat islets of Langerhans. Diabetes 33, 296 (1984).
    • (1984) Diabetes , vol.33 , pp. 296
    • Hii, C.S.1    Howell, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.