Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptor

Journal of Neurochemistry

Volumn 124, Issue 2, 2013, Pages 200-209

  Laha, Kurt T ^a   Tran, Phu N ^a  

^a Marquette University   (United States)

Author keywords

GABA binding; GABAA receptor; kinetics; surface expression

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALANINE; PHENYLALANINE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CELL STRAIN HEK293; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GABAERGIC TRANSMISSION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATIONAL ANALYSIS; NERVE CELL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RESIDUE ANALYSIS;

BINDING SITES; DOWN-REGULATION; HEK293 CELLS; HUMANS; NEURAL INHIBITION; RECEPTORS, GABA-A; TYROSINE;

EID: 84871612373     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12083     Document Type: Article

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