A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells

Investigational New Drugs

Volumn 29, Issue 4, 2011, Pages 523-533

  Shahabuddin, M S ^a   Nambiar, Mridula ^a   Moorthy, Balaji T ^a   Naik, Prakruthi L ^b   Choudhary, Bibha ^a   Advirao, Gopal M ^b   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b KUVEMPU UNIVERSITY   (India)

Author keywords

Anti cancer drugs; Chemotherapy; Cytotoxicity; DNA damage; Double strand breaks

Indexed keywords

8 METHYL 4 (3 DIETHYLAMINOPROPYLAMINO)PYRIMIDO[4',5':4,5]SELENOLO[2,3 B]QUINOLINE; ELLIPTICINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

ALKALOIDS; ANNEXIN A5; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; DNA REPAIR; DNA REPLICATION; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ELLIPTICINES; GENOMIC INSTABILITY; HUMANS; LEUKEMIA; NECROSIS; NEOPLASM PROTEINS; ORGANOSELENIUM COMPOUNDS; PHOSPHATIDYLSERINES; PROPIDIUM;

EID: 79959743966     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-009-9379-5     Document Type: Article

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