A novel DNA intercalator, butylamino-pyrimido[4,5:4,5]selenolo(2,3-b) quinoline, induces cell cycle arrest and apoptosis in leukemic cells

Investigational New Drugs

Volumn 28, Issue 1, 2010, Pages 35-48

  Shahabuddin, M S ^a   Nambiar, Mridula ^a   Choudhary, Bibha ^b   Advirao, Gopal M ^c   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b Manipal Academy of Higher Education   (India)

^c KUVEMPU UNIVERSITY   (India)

Author keywords

Anticancer drug; Chemotherapy; Cytotoxicity; DNA damage; Double strand breaks

Indexed keywords

4 BUTYLAMINOPYRIMIDO[4',5':4,5]SELENOLO(2,3 B)QUINOLINE; 4 PIPERAZINOPYRIMIDO[4',5':4,5]SELENOLO(2,3 B)QUINOLINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; HISTONE; INTERCALATING AGENT; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BCL 2; THYMIDINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; DNA; DNA FRAGMENTATION; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INTERCALATING AGENTS; K562 CELLS; LEUKEMIA; ORGANOSELENIUM COMPOUNDS; PHOSPHATIDYLSERINES; QUINOLINES;

EID: 74149087991     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9212-6     Document Type: Article

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