Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

FEBS Letters

Volumn 582, Issue 29, 2008, Pages 4066-4076

  Chiruvella, Kishore K ^a   Kari, Vijayalakshmi ^a   Choudhary, Bibha ^b   Nambiar, Mridula ^a   Ghanta, Rama Gopal ^c   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b Manipal Academy of Higher Education   (India)

^c SRI VENKATESWARA UNIVERSITY   (India)

Author keywords

Callus; Cancer therapeutics; Chemotherapy; Cytotoxicity; DNA damage; Double strand break

Indexed keywords

CASPASE 3; CASPASE 9; KU ANTIGEN; METHYL ANGOLENSATE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAD; PROTEIN BCL 2; TETRANORTRITERPENOID; TRITERPENOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 8; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLLAGEN TYPE XI; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, T-CELL; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; TRITERPENES;

EID: 56649100467     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.11.001     Document Type: Article

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