Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Roescher, Nienke ^a,b   Vosters, Jelle L ^a,b   Lai, Zhenan ^a   Uede, Toshimitsu ^d   Tak, Paul P ^b,c   Chiorini, John A ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c GLAXOSMITHKLINE   (United Kingdom)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; PARVOVIRUS VECTOR; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CELL TYPE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOCUS SCORE; FUNCTIONAL ASSESSMENT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; MICROARRAY ANALYSIS; MOUSE; MULTICENTER STUDY; NONHUMAN; NONOBESE DIABETIC MOUSE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SALIVARY GLAND; SALIVARY GLAND FUNCTION; SALIVATION; SCORING SYSTEM; SJOEGREN SYNDROME; TREATMENT RESPONSE;

ANIMALS; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CD40 LIGAND; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GENETIC VECTORS; INFLAMMATION; MICE; MICE, INBRED NOD; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, FC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALIVARY GLANDS; SJOGREN'S SYNDROME;

MURINAE; MUS;

EID: 84871604572     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051375     Document Type: Article

References (40)

1. Cha S, Peck AB, Humphreys-Beher MG, (2002) Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit Rev Oral Biol Med 13: 5-16.
2. Roescher N, Lodde B, Vosters J, Tak P, Catalan M, et al. (2011) Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjogren's syndrome. Oral Dis.
3. van Kooten C, Banchereau J, (1997) Immune regulation by CD40-CD40-L interactions. Front Biosci 2: d1-11.
4. Schonbeck U, Libby P, (2001) The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 58: 4-43.
5. Dimitriou ID, Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN, (2002) CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjogren's syndrome patients indicating their intrinsic activation. Clin Exp Immunol 127: 386-392.
6. Ohlsson M, Szodoray P, Loro LL, Johannessen AC, Jonsson R, (2002) CD40, CD154, Bax and Bcl-2 expression in Sjogren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Scand J Immunol 56: 561-571.
7. Karmann K, Hughes CC, Schechner J, Fanslow WC, Pober JS, (1995) CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci U S A 92: 4342-4346.
8. Saito M, Ota Y, Ohashi H, Dei Y, Shimoyama K, et al. (2007) CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-kappa B p50 in cultured salivary gland epithelial cells from patients with Sjogren's syndrome. Mod Rheumatol 17: 45-53.
9. Chang GJ, Liu T, Feng S, Bedolli M, O'Rourke RW, et al. (2002) Targeted gene therapy with CD40Ig to induce long-term acceptance of liver allografts. Surgery 132: 149-156.
10. Kanaya K, Tsuchida Y, Inobe M, Murakami M, Hirose T, et al. (2003) Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation 75: 275-281.
11. Nomura M, Yamashita K, Murakami M, Takehara M, Echizenya H, et al. (2002) Induction of donor-specific tolerance by adenovirus-mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 73: 1403-1410.
12. Balasa B, Krahl T, Patstone G, Lee J, Tisch R, et al. (1997) CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol 159: 4620-4627.
13. Girvin AM, Dal Canto MC, Miller SD, (2002) CD40/CD40L interaction is essential for the induction of EAE in the absence of CD28-mediated co-stimulation. J Autoimmun 18: 83-94.
14. Kok MR, Voutetakis A, Yamano S, Wang J, Cotrim A, et al. (2005) Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors. J Gene Med 7: 432-441.
15. Maia AL, Berry MJ, Sabbag R, Harney JW, Larsen PR, (1995) Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Mol Endocrinol 9: 969-980.
16. van Haasteren GA, van der Meer MJ, Hermus AR, Linkels E, Klootwijk W, et al. (1994) Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis. Endocrinology 135: 1336-1345.
17. Lonnerdal B, Iyer S, (1995) Lactoferrin: molecular structure and biological function. Annu Rev Nutr 15: 93-110.
18. Curran CS, Demick KP, Mansfield JM, (2006) Lactoferrin activates macrophages via TLR4-dependent and-independent signaling pathways. Cell Immunol 242: 23-30.
19. Madsen J, Tornoe I, Nielsen O, Lausen M, Krebs I, et al. (2003) CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol. 33: 2327-2336.
20. Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, et al. (2002) Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A 99: 1497-1502.
21. Zincarelli C, Soltys S, Rengo G, Rabinowitz JE, (2008) Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Mol Ther 16: 1073-1080.
22. Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF, (2001) Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem 268: 1508-1515.
23. Haxhinasto SA, Hostager BS, Bishop GA, (2002) Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction. J Immunol 169: 1145-1149.
24. Munroe ME, Bishop GA, (2007) A costimulatory function for T cell CD40. J Immunol 178: 671-682.
25. Qian Y, Zhao Z, Jiang Z, Li X, (2002) Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci U S A 99: 9386-9391.
26. Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, et al. (2007) TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J 26: 1150-1162.
27. Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, et al. (2008) TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Exp Cell Res 314: 2725-2738.
28. Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, et al. (2003) Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22: 412-425.
29. Nguyen VT, Walker WS, Benveniste EN, (1998) Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur J Immunol 28: 2537-2548.
30. Roescher N, Vosters JL, Yin H, Illei GG, Tak PP, et al. (2011) Effect of soluble ICAM-1 on a Sjogren's syndrome-like phenotype in NOD mice is disease stage dependent. PLoS One 6: e19962.
31. Najafian N, Khoury SJ, (2003) T cell costimulatory pathways: blockade for autoimmunity. Expert Opin Biol Ther 3: 227-236.
32. Kirk AD, Harlan DM, Armstrong NN, Davis TA, Dong Y, et al. (1997) CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 94: 8789-8794.
33. Mauri C, Mars LT, Londei M, (2000) Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med 6: 673-679.
34. Kelly JA, Lessard CJ, Adrianto I, Ice JA, Li H, et al. (2011) Gene Expression Profiling in a Cohort of 275 European American Sjögren's Syndrome Patients and Controls. ACR 2011 abstract 489.
35. Sidiropoulos PI, Boumpas DT, (2004) Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 13(5): 391-397.
36. Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ, (2003) CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res 16 92(9): 1041-1048.
37. Kaludov N, Brown KE, Walters RW, Zabner J, Chiorini JA, (2001) Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. J Virol 75: 6884-6893.
38. Grimm D, Kern A, Rittner K, Kleinschmidt JA, (1998) Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther 9: 2745-2760.
39. Hu Y, Nakagawa Y, Purushotham KR, Humphreys-Beher MG, (1992) Functional changes in salivary glands of autoimmune disease-prone NOD mice. Am J Physiol 263: E607-614.
40. Greenspan JS, Daniels TE, Talal N, Sylvester RA, (1974) The histopathology of Sjogren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol 37: 217-229.