Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model

Transplantation

Volumn 75, Issue 3, 2003, Pages 275-281

  Kanaya, Kohei ^a,b   Tsuchida, Yoshihiko ^b   Inobe, Manabu ^a   Murakami, Masaaki ^a   Hirose, Toshiaki ^a,b   Kon, Shigeyuki ^a   Kawaguchi, Satoshi ^b   Wada, Takuro ^b   Yamashita, Toshihiko ^b   Ishii, Seiichi ^b   Uede, Toshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CD40 LIGAND; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 IMMUNOGLOBULIN; IMMUNOGLOBULIN; RECOMBINANT ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; COMPOSITE GRAFT; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE; GENE THERAPY; GENE TRANSFER; GRAFT REJECTION; GRAFT SURVIVAL; HETEROTOPIC TRANSPLANTATION; HINDLIMB; MALE; NONHUMAN; PLAQUE FORMING CELL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RAT; RAT STRAIN; TIME; TREATMENT OUTCOME; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD40; FEMALE; GENE THERAPY; GENETIC VECTORS; GRAFT REJECTION; GRAFT SURVIVAL; HINDLIMB; IMMUNOCONJUGATES; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED ACI; RATS, INBRED LEW; TRANSGENES; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0037442196     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000046966.35399.75     Document Type: Article

References (42)

1. Black KS, Hewitt CW, Fraser LA, et al. Composite tissue (limb) allografts in rats. II. Indefinite survival using low-dose cyclosporine. Transplantation 1985; 39: 365.
2. Arai K, Hotokebuchi T, Miyahara H, et al. Limb allografts immunosuppressed with FK506. Transplantation 1989; 48: 782.
3. Behaim P, Anthony JP, Lin LYT, et al. A long-term study of allogeneic rat hind limb transplants immunosuppressed with RS-61443. Transplantation 1993; 56: 911.
4. Fealy MJ, Umansky WS, Bickel KD, et al. Efficacy of rapamycin and FK506 in prolonging rat hind limb allograft survival. Ann Surg 1994; 219: 88.
5. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft; report on first 6 months. Lancet 1999; 353: 1315.
6. Jones JW, Gruber SA, Barker JH, et al. Successful hand transplantation. N Engl J Med 2000; 343: 468.
7. Francois CG, Breidenbach WC, Maldonado C, et al. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery 2000; 20: 360.
8. Kann BR, Furnas DW, Hewitt CW. Past, present, and future research in the field of composite tissue allotransplantation. Microsurgery 2000; 20: 393.
9. Cendales L, Hardy MA. Immunological considerations in composite tissue transplantation: overview. Microsurgery 2000; 20: 412.
10. Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987; 165: 302.
11. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349.
12. Bousiotis VA, Freeman GJ, Gray G, et al. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human of human alloantigen-specific tolerance. J Exp Med 1993; 178: 1753.
13. Linsley PS, Wallace PM, Johnson J, et al. Immunosuppression in vivo by a soluble form of the CTLA4, T cell activation molecules. Science 1992; 257: 792.
14. Lenshow DJ, Zeng Y, Thistlethawaite JR, et al. Long-term survival of xenogenic pancreatic islet grafts induced by CTLA4Ig. Science 1992; 257: 789.
15. Tarumi K, Murakami M, Yagihashi A, et al. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 1999; 67: 520.
16. Yamada A, Konishi K, Cruz G, et al. Blocking the CD28-B7 T-cell costimulatory pathway abrogates the development of obliterative bronchiolitis in murine heterotopic airway model. Transplantation 2000; 69: 743.
17. Takehara M, Murakami M, Inobe M, et al. Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and lox P. Hum Gene Ther 2001; 12: 415.
18. Lee WPA, Yaremchuck MJ, Pan YC, et al. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg 1991; 87: 401.
19. Tsuchida Y, Usui M, Murakami M, et al. Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. Transplant Proc 1997; 29; 1732.
20. Iwasaki N, Gohda T, Yoshioka C, et al. Feasibility of immunosuppression in composite tissue allografts by systemic administration of CTLA4Ig. Transplantation 2002; 73: 334.
21. Lasen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection. Transplantation 1996; 61: 4.
22. Kirk AD, Burkly LC, Batly DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allografts rejection in non human primates. Nature Med 1999; 5: 686.
23. Kenyon NS, Chtzipetrou M, Masetti M, et al. Long-term survival and function of intrahepatic islet allografts in rhesus monkey with humanized anti-CD154. Proc Natl Acad Sci U S A 1999; 96: 8132.
24. Ranheim EA, Kipps TH. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993; 177: 925.
25. Roy M, Aruffo A, Ledbetter J, et al. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol 1995; 25: 596.
26. Nomura M, Yamashita K, Murakami M, et al. Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 2002; 73: 1403.
27. Nakagawa I, Murakami M, Ijima M, et al. Persistent and second adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Hum Gene Ther 1998; 9: 1739.
28. Buttemyer R, Jones NF, Min Z, et al. Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. Plast Reconstr Surg 1996; 97: 139.
29. Yano Y, Hara M, Miyashita T, et al. Microchimeric cells from the peripheral blood associated with cardiac grafts are bone marrow derived, long lived and maintain acquired tolerance to minor histocompatibility antigen H-Y. Transplantation 2001; 71: 456.
30. Kakinoki R, Bishop AT, Tu YK, et al. Detection of the proliferated donor cells in bone grafts in rats, using a PCR for a Y-chromosome-specific gene. J Orthop Sci 2002; 7: 252.
31. Thompson AW, Starzl TE. New immunosuppressive drugs: mechanistic insights and potential therapeutic advances. Immunol Rev 1993; 136: 71.
32. Kita Y, Lix R, Ohba M, et al. Prolonged cardiac allograft survival in rats systemically injected adenoviral vectors containing CTLA4Ig-gene. Transplantation 1999; 68: 758.
33. Linsley PS, Ledbettr JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993; 11: 191.
34. Van Gool SW, Vandenberghe P, Banchereau J, et al. The CD40 antigen and its ligand. Annu Rev Immunol 1994; 12: 881.
35. Clarke, SR. The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity. J Leukoc Biol 2000; 67: 607.
36. Lasen CP, Elwood ET, Alexander DZ, et al. Long term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
37. Kawai T, Alexander DZ, Colvin RB, et al. Thromboembolic complication after treatment with monoclonal antibody against CD40 ligand. Nature Med 2000; 6: 114.
38. Kirk AD, Knechtle SJ, Sollinger HW, et al. Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation. Am J Transplant 2001; 191: A223.
39. Morral N, O'Neal WK, Rice K, et al. Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons. Hum Gene Ther 2002; 13: 143.
40. National Institutes of Health. Assessment of adenoviral vector safety and toxicity: report of the National Institutes of Health Recombinant DNA Advisory Committee. Hum Gene Ther 2002; 13: 3.
41. Hewitt CW, Ramsamooj R, Patel MP, et al. Development of stable mixed T cell chimerism and transplantation tolerance without immune modulation in recipients of vascularized bone marrow allografts. Transplantation 1990; 50: 766.
42. Durlik M, Lukomska B, Religa P, et al. Tolerance induction following allogeneic vascularized bone marrow transplantation: the possible role of microchimerism. Transpl Int 1998; 11(suppl): 5299.