Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 23-28

  Sun, Juan ^a   Zhu, Hui ^a   Yang, Zhong Ming ^a   Zhu, Hai Liang ^a  

^a SHANDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1,3,4 Oxadiazole; Antiproliferative; Molecular docking; Quinoline; Telomerase inhibitor

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 3 (MORPHOLINOMETHYL) 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [(4 PHENYLPIPERAZIN 1 YL)METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [(PHENYLAMINO)METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [(PYRIDIN 2 YLAMINO)METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(2 BROMOPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(2 CHLOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(2 ETHOXYPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(2 FLUOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(3 CHLOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(3 FLUOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(4 CHLOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[(4 FLUOROPHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[ETHYL(PHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 3 [[METHYL(PHENYL)AMINO]METHYL] 5 (QUINOLIN 2 YL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (QUINOLIN 2 YL) 3 [(PARA TOLYLAMINO)METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; ANTINEOPLASTIC AGENT; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; POLYMERASE CHAIN REACTION; SIMULATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 84871576936     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.039     Document Type: Article

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