Synthesis of new δ2-isoxazoline derivatives and their pharmacological characterization as β-adrenergic receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 4, 1998, Pages 401-408

  Conti, Paola ^a   Dallanoce, Clelia ^a   De Amici, Marco ^a   De Micheli, Carlo ^a   Klotz, Karl Norbert ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Adrenergic antagonists; Binding affinity; Broxaterol analogs; Falintolol analogs; Synthesis

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BROXATEROL; CYANOPINDOLOL; FALINTOLOL; ISOXAZOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHO CELL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVATION; GLIOMA CELL; NONHUMAN; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CHROMATOGRAPHY, THIN LAYER; CRICETINAE; GLIOMA; HUMANS; ISOXAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; PINDOLOL; PROPANOLAMINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032053997     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10051-7     Document Type: Article

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