Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 51, 2012, Pages 12451-12457

  Lin, Chiu Mei ^a,b,c   Chen, Yen Hsu ^d,e   Ma, Hon Ping ^f   Wang, Bao Wei ^a   Chiu, Jen Hwey ^g   Chua, Su Kiat ^a   Ong, Jiann Ruey ^a   Shyu, Kou Gi ^a,f  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL ILAN UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

AP 1; colon cancer; IL 6; MMP 2; silibinin

Indexed keywords

AP-1; COLON CANCER; IL-6; MMP-2; SILIBININ;

CELL PROLIFERATION; CELLS; CONFOCAL MICROSCOPY; FLAVONOIDS; PROTEINS;

IMMUNOLOGY;

GELATINASE A; INTERLEUKIN 6; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN KINASE INHIBITOR; SILIBININ; SILYMARIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CANCER INVASION; CELL PROLIFERATION; COLON TUMOR; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; PATHOLOGY; PROMOTER REGION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; NEOPLASM INVASIVENESS; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; SILYMARIN; TRANSCRIPTION FACTOR AP-1;

EID: 84871546051     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf300964f     Document Type: Article

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