메뉴 건너뛰기




Volumn , Issue , 2011, Pages 71-84

Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for down syndrome

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84871509540     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511919299.006     Document Type: Chapter
Times cited : (7)

References (72)
  • 1
    • 0035445736 scopus 로고    scopus 로고
    • Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
    • Altafaj, X., Dierssen, M., Baamonde, C., et al. (2001). Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Human Molecular Genetics, 10, 1915-1923.
    • (2001) Human Molecular Genetics , vol.10 , pp. 1915-1923
    • Altafaj, X.1    Dierssen, M.2    Baamonde, C.3
  • 2
    • 0013784893 scopus 로고
    • Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
    • Altman, J. & Das, G. D. (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. Journal of Comparative Neurology, 124, 319-335.
    • (1965) Journal of Comparative Neurology , vol.124 , pp. 319-335
    • Altman, J.1    Das, G.D.2
  • 4
    • 65949098892 scopus 로고    scopus 로고
    • The “Down syndrome critical region” is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    • Belichenko, N. P., Belichenko, P. V., Kleschevnikov, A. M., et al. (2009). The “Down syndrome critical region” is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. Journal of Neuroscience, 29, 5938-5948.
    • (2009) Journal of Neuroscience , vol.29 , pp. 5938-5948
    • Belichenko, N.P.1    Belichenko, P.V.2    Kleschevnikov, A.M.3
  • 5
    • 9644278035 scopus 로고    scopus 로고
    • Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome
    • Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., et al. (2004). Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. Journal ofComparative Neurology, 480, 281-298.
    • (2004) Journal ofComparative Neurology , vol.480 , pp. 281-298
    • Belichenko, P.V.1    Masliah, E.2    Kleschevnikov, A.M.3
  • 6
    • 0346749428 scopus 로고    scopus 로고
    • Enriched environment confers resistance to 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: Involvement of dopamine transporter and trophic factors
    • Bezard, E., Dovero, S., Belin, D., et al. (2003). Enriched environment confers resistance to 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: Involvement of dopamine transporter and trophic factors. Journal of Neuroscience, 23, 10999-101007.
    • (2003) Journal of Neuroscience , vol.23 , pp. 10999-101007
    • Bezard, E.1    Dovero, S.2    Belin, D.3
  • 8
    • 35548970343 scopus 로고    scopus 로고
    • Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome
    • Chakrabarti, L., Galdzicki, Z., Haydar, T. F. (2007). Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. Journal ofNeuroscience, 27, 1483-1495.
    • (2007) Journal ofNeuroscience , vol.27 , pp. 1483-1495
    • Chakrabarti, L.1    Galdzicki, Z.2    Haydar, T.F.3
  • 10
    • 33746047443 scopus 로고    scopus 로고
    • Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
    • Clark, S., Schwalbe, J., Stasko, M. R., Yarowsky, P. J., Costa, A. C. (2006). Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Experimental Neurology, 200, 256261.
    • (2006) Experimental Neurology , vol.200 , pp. 256-261
    • Clark, S.1    Schwalbe, J.2    Stasko, M.R.3    Yarowsky, P.J.4    Costa, A.C.5
  • 11
    • 61649106285 scopus 로고    scopus 로고
    • Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome
    • Contestabile, A., Fila, T., Bartesaghi, R., Ciani, E. (2009). Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. Brain Pathology, 19, 224-237.
    • (2009) Brain Pathology , vol.19 , pp. 224-237
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Ciani, E.4
  • 12
    • 34548102066 scopus 로고    scopus 로고
    • Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice
    • Contestabile, A., Fila, T., Ceccarelli, C., et al. (2007). Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus, 17, 665678.
    • (2007) Hippocampus , vol.17 , pp. 665-678
    • Contestabile, A.1    Fila, T.2    Ceccarelli, C.3
  • 13
    • 0025663975 scopus 로고
    • Segmental trisomy of murine chromosome 16: A new model system for studying Down syndrome
    • Davisson, M. T., Schmidt, C, Akeson, E. C. (1990). Segmental trisomy of murine chromosome 16: A new model system for studying Down syndrome. Progress in Clinical and Biological Research, 360, 263-280.
    • (1990) Progress in Clinical and Biological Research , vol.360 , pp. 263-280
    • Davisson, M.T.1    Schmidt, C.2    Akeson, E.C.3
  • 14
    • 0027874350 scopus 로고
    • Molecular mapping of twenty-four features of Down syndrome on chromosome 21
    • Delabar, J. M., Theophiie, D., Rahmani, Z., et al. (1993). Molecular mapping of twenty-four features of Down syndrome on chromosome 21. European Journal of Human Genetics, 1, 114-124.
    • (1993) European Journal of Human Genetics , vol.1 , pp. 114-124
    • Delabar, J.M.1    Theophiie, D.2    Rahmani, Z.3
  • 15
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of environmental enrichment
    • Dierssen, M., Benavides-Piccione, R., Martinez-Cue, C., et al. (2003). Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of environmental enrichment. Cerebral Cortex, 13, 758-764.
    • (2003) Cerebral Cortex , vol.13 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martinez-Cue, C.3
  • 16
    • 33846430088 scopus 로고    scopus 로고
    • Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
    • Dowjat, W. K., Adayev, T., Kuchna, I., et al. (2007). Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Neuroscience Letters, 413, 77-81.
    • (2007) Neuroscience Letters , vol.413 , pp. 77-81
    • Dowjat, W.K.1    Adayev, T.2    Kuchna, I.3
  • 17
    • 0022547120 scopus 로고
    • Developmental genetics
    • Epstein, C. J. (1986). Developmental genetics. Experientia, 42, 1117-1128.
    • (1986) Experientia , vol.42 , pp. 1117-1128
    • Epstein, C.J.1
  • 18
    • 67449168368 scopus 로고    scopus 로고
    • Normal protein composition of synapses in Ts65Dn mice: A mouse model of Down syndrome
    • Fernandez, F., Trinidad, J. C., Blank, M., et al. (2009). Normal protein composition of synapses in Ts65Dn mice: A mouse model of Down syndrome. Journal of Neurochemistry, 110, 157-169.
    • (2009) Journal of Neurochemistry , vol.110 , pp. 157-169
    • Fernandez, F.1    Trinidad, J.C.2    Blank, M.3
  • 19
    • 0018097002 scopus 로고
    • Environmental complexity modulates growth of granule cell dendrites in developing but not adult hippocampus of rats
    • Fiala, B. A., Joyce, J. N., Greenough, W. T. (1978). Environmental complexity modulates growth of granule cell dendrites in developing but not adult hippocampus of rats. Experimental Neurology, 59, 372-383.
    • (1978) Experimental Neurology , vol.59 , pp. 372-383
    • Fiala, B.A.1    Joyce, J.N.2    Greenough, W.T.3
  • 20
    • 0036724569 scopus 로고    scopus 로고
    • Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
    • Fotaki, V., Dierssen, M., Alcantara, S., et al. (2002). Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Molecular and Cellular Biology, 22, 6636-6647.
    • (2002) Molecular and Cellular Biology , vol.22 , pp. 6636-6647
    • Fotaki, V.1    Dierssen, M.2    Alcantara, S.3
  • 21
    • 75149166144 scopus 로고    scopus 로고
    • Molecular basis of pharmacotherapies for cognition in Down syndrome
    • Gardiner, K. J. (2010). Molecular basis of pharmacotherapies for cognition in Down syndrome. Trends in Pharmacological Sciences, 31, 66-73.
    • (2010) Trends in Pharmacological Sciences , vol.31 , pp. 66-73
    • Gardiner, K.J.1
  • 23
    • 10144260033 scopus 로고    scopus 로고
    • A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region
    • Guimera, J., Casas, C., Pucharcos, C., et al. (1996). A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Human Molecular Genetics, 5, 1305-1310.
    • (1996) Human Molecular Genetics , vol.5 , pp. 1305-1310
    • Guimera, J.1    Casas, C.2    Pucharcos, C.3
  • 25
    • 0038391317 scopus 로고    scopus 로고
    • Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation
    • Hammerle, B., Carnicero, A., Elizalde, C., et al. (2003). Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation. European Journal of Neuroscience, 17, 2277-2286.
    • (2003) European Journal of Neuroscience , vol.17 , pp. 2277-2286
    • Hammerle, B.1    Carnicero, A.2    Elizalde, C.3
  • 26
    • 0000152483 scopus 로고
    • The effects of early experience on problem solving at maturity
    • Hebb, D. O. (1947). The effects of early experience on problem solving at maturity. The American Psychologist, 2, 306-307.
    • (1947) The American Psychologist , vol.2 , pp. 306-307
    • Hebb, D.O.1
  • 28
    • 77951096438 scopus 로고    scopus 로고
    • Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome
    • Ishihara, K., Amano, K., Takaki, E., et al. (2010). Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cerebral Cortex, 20, 1131-1143.
    • (2010) Cerebral Cortex , vol.20 , pp. 1131-1143
    • Ishihara, K.1    Amano, K.2    Takaki, E.3
  • 29
    • 0037262305 scopus 로고    scopus 로고
    • Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    • Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., Gage, F. H. (2003). Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development, 130, 391-399.
    • (2003) Development , vol.130 , pp. 391-399
    • Kempermann, G.1    Gast, D.2    Kronenberg, G.3    Yamaguchi, M.4    Gage, F.H.5
  • 30
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann, G., Kuhn, H. G., Gage, F. H. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, 386, 493-495.
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 31
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., et al. (2004). Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. Journal of Neuroscience, 24, 8153-8160.
    • (2004) Journal of Neuroscience , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Villar, A.J.3
  • 33
    • 0026583894 scopus 로고
    • Down syndrome: Molecular mapping of the congenital heart disease and duodenal stenosis
    • Korenberg, J. R., Bradley, C., Disteche, C. M. (1992). Down syndrome: Molecular mapping of the congenital heart disease and duodenal stenosis. American Journal ofHuman Genetics, 50, 294-302.
    • (1992) American Journal ofHuman Genetics , vol.50 , pp. 294-302
    • Korenberg, J.R.1    Bradley, C.2    Disteche, C.M.3
  • 34
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • Kurt, M. A., Kafa, M. I., Dierssen, M., Davies, D. C. (2004). Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Research, 1022, 101-109.
    • (2004) Brain Research , vol.1022 , pp. 101-109
    • Kurt, M.A.1    Kafa, M.I.2    Dierssen, M.3    Davies, D.C.4
  • 35
    • 16844383069 scopus 로고    scopus 로고
    • Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice
    • Lambert, T. J., Fernandez, S. M., Frick, K. M. (2005). Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice. Neurobiology of Learning and Memory, 83, 206-216.
    • (2005) Neurobiology of Learning and Memory , vol.83 , pp. 206-216
    • Lambert, T.J.1    Fernandez, S.M.2    Frick, K.M.3
  • 36
    • 20044377403 scopus 로고    scopus 로고
    • Environmental enrichment reduces Ab levels and amyloid deposition in transgenic mice
    • Lazarov, O., Robinson, J., Tang, Y. P., et al. (2005). Environmental enrichment reduces Ab levels and amyloid deposition in transgenic mice. Cell, 120, 701-713.
    • (2005) Cell , vol.120 , pp. 701-713
    • Lazarov, O.1    Robinson, J.2    Tang, Y.P.3
  • 37
    • 33746585652 scopus 로고    scopus 로고
    • Hippocampal hypocellularity in the Ts65Dn mouse originates early in development
    • Lorenzi, H. A. & Reeves, R. H. (2006). Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Research, 1104, 153-159.
    • (2006) Brain Research , vol.1104 , pp. 153-159
    • Lorenzi, H.A.1    Reeves, R.H.2
  • 38
    • 62849113692 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21
    • Lyle, R., Bena, F., Gagos, S., et al. (2009). Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. European Journal of Human Genetics, 17, 454-466.
    • (2009) European Journal of Human Genetics , vol.17 , pp. 454-466
    • Lyle, R.1    Bena, F.2    Gagos, S.3
  • 39
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • Martlnez-Cue, C., Baamonde, C., Lumbreras, M., et al. (2002). Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behavioral Brain Research, 134, 185-200.
    • (2002) Behavioral Brain Research , vol.134 , pp. 185-200
    • Martlnez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3
  • 40
    • 0019974174 scopus 로고
    • Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies
    • Miyabara, S., Gropp, A., Winking, H. (1982). Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies. Teratology 25, 369-80.
    • (1982) Teratology 25 , pp. 369-380
    • Miyabara, S.1    Gropp, A.2    Winking, H.3
  • 41
    • 47549096987 scopus 로고    scopus 로고
    • Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome
    • Morice, E., Andreae, L. C., Cooke, S. F., et al. (2008). Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learning and Memory, 15, 492-500.
    • (2008) Learning and Memory , vol.15 , pp. 492-500
    • Morice, E.1    Andreae, L.C.2    Cooke, S.F.3
  • 42
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experience-dependent plasticity and disorders of the nervous system
    • Nithianantharajah, J. & Hannan, A. J. (2006). Enriched environments, experience-dependent plasticity and disorders of the nervous system. National Reviews Neuroscience, 7, 697-709.
    • (2006) National Reviews Neuroscience , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 43
    • 25444442381 scopus 로고    scopus 로고
    • An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes
    • Odoherty, A., Ruf, S., Mulligan, C., et al. (2005). An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science, 23, 2033-2037.
    • (2005) Science , vol.23 , pp. 2033-2037
    • Odoherty, A.1    Ruf, S.2    Mulligan, C.3
  • 44
    • 7444231620 scopus 로고    scopus 로고
    • A chromosome 21 critical region does not cause specific Down syndrome phenotypes
    • Olson, L. E., Richtsmeier, J. T., Leszl, J., Reeves, R. H. (2004). A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science, 306, 687-690.
    • (2004) Science , vol.306 , pp. 687-690
    • Olson, L.E.1    Richtsmeier, J.T.2    Leszl, J.3    Reeves, R.H.4
  • 45
    • 34447338354 scopus 로고    scopus 로고
    • Trisomy for the Down syndrome ‘critical region’ is necessary but not sufficient for brain phenotypes of trisomic mice
    • Olson, L. E., Roper, R. J., Sengstaken, C. L., et al. (2007). Trisomy for the Down syndrome ‘critical region’ is necessary but not sufficient for brain phenotypes of trisomic mice. Human Molecular Genetics, 16, 774-782.
    • (2007) Human Molecular Genetics , vol.16 , pp. 774-782
    • Olson, L.E.1    Roper, R.J.2    Sengstaken, C.L.3
  • 46
    • 0038687498 scopus 로고    scopus 로고
    • The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction
    • Pennington, B. F., Moon, J., Edgin, J., Stedron, J., Nadel, L. (2003). The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction. Child Development, 74, 75-93.
    • (2003) Child Development , vol.74 , pp. 75-93
    • Pennington, B.F.1    Moon, J.2    Edgin, J.3    Stedron, J.4    Nadel, L.5
  • 47
    • 70450161234 scopus 로고    scopus 로고
    • A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of Down syndrome
    • Pereira, P. L., Magnol, L., Sahuen, I., et al. (2009). A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of Down syndrome. Human Molecular Genetics, 18, 4756-4769.
    • (2009) Human Molecular Genetics , vol.18 , pp. 4756-4769
    • Pereira, P.L.1    Magnol, L.2    Sahuen, I.3
  • 48
    • 51249103592 scopus 로고    scopus 로고
    • Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn
    • Pollonini, G., Gao, V., Rabe, A., et al. (2008). Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience, 156, 99-106.
    • (2008) Neuroscience , vol.156 , pp. 99-106
    • Pollonini, G.1    Gao, V.2    Rabe, A.3
  • 49
    • 0029114706 scopus 로고
    • A mouse model for Down syndrome exhibits learning and behaviour deficits
    • Reeves, R. H., Irving, N. G., Moran, T. H., et al. (1995). A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genetics, 11, 177-184.
    • (1995) Nature Genetics , vol.11 , pp. 177-184
    • Reeves, R.H.1    Irving, N.G.2    Moran, T.H.3
  • 51
    • 0013897725 scopus 로고
    • Environmental complexity, cerebral change, and behavior
    • Rosenzweig, M. R. (1966). Environmental complexity, cerebral change, and behavior. The American Psychologist, 21, 321-332.
    • (1966) The American Psychologist , vol.21 , pp. 321-332
    • Rosenzweig, M.R.1
  • 52
    • 0018127151 scopus 로고
    • Social grouping cannot account for cerebral effects of enriched environments
    • Rosenzweig, M. R., Bennett, E. L., Hebert, M., Morimoto, H. (1978). Social grouping cannot account for cerebral effects of enriched environments. Brain Research, 153, 563-576.
    • (1978) Brain Research , vol.153 , pp. 563-576
    • Rosenzweig, M.R.1    Bennett, E.L.2    Hebert, M.3    Morimoto, H.4
  • 53
    • 18044369095 scopus 로고    scopus 로고
    • Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome
    • Rueda, N., Mostany, R., Pazos, A., Florez, J., Martinez-Cue, C. (2005). Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neuroscience Letters, 380,197-201.
    • (2005) Neuroscience Letters , vol.380 , pp. 197-201
    • Rueda, N.1    Mostany, R.2    Pazos, A.3    Florez, J.4    Martinez-Cue, C.5
  • 55
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago, H., Carlson, E. J., Smith, D. J., et al. (2000). Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatric Research, 48, 606-613.
    • (2000) Pediatric Research , vol.48 , pp. 606-613
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3
  • 57
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • Siarey, R. J., Carlson, E. J., Epstein, C. J., et al. (1999). Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology, 38, 1917-1920.
    • (1999) Neuropharmacology , vol.38 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3
  • 58
    • 21344435258 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome
    • Siarey, R. J., Villar, A. J., Epstein, C. J., Galdzicki, Z. (2005). Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology, 49, 122-128.
    • (2005) Neuropharmacology , vol.49 , pp. 122-128
    • Siarey, R.J.1    Villar, A.J.2    Epstein, C.J.3    Galdzicki, Z.4
  • 59
    • 0030589579 scopus 로고    scopus 로고
    • Isolation of human and murine homologues of the Drosophila minibrain gene: Human homologue maps to 21q22.2 in the Down syndrome “critical region”
    • Song, W. J., Sternberg, L. R., Kasten-Sportes, C., et al. (1996). Isolation of human and murine homologues of the Drosophila minibrain gene: Human homologue maps to 21q22.2 in the Down syndrome “critical region”. Genomics, 15, 331-339.
    • (1996) Genomics , vol.15 , pp. 331-339
    • Song, W.J.1    Sternberg, L.R.2    Kasten-Sportes, C.3
  • 60
    • 1542286877 scopus 로고    scopus 로고
    • Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    • Spires, T. L., Grote, H. E., Varshney, N. K, et al. (2004). Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. Journal ofNeuroscience, 24, 2270-2276.
    • (2004) Journal ofNeuroscience , vol.24 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3
  • 62
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag, H., Kempermann, G., Gage, F. H. (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience, 2, 266-270.
    • (1999) Nature Neuroscience , vol.2 , pp. 266-270
    • Van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 64
    • 34547802614 scopus 로고    scopus 로고
    • Immunohistological markers for staging neurogenesis in adult hippocampus
    • von Bohlen Und Halbach, O. (2007). Immunohistological markers for staging neurogenesis in adult hippocampus. Cell and Tissue Research, 329, 409-420.
    • (2007) Cell and Tissue Research , vol.329 , pp. 409-420
    • Von Bohlen Und Halbach, O.1
  • 66
    • 51849158177 scopus 로고    scopus 로고
    • The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    • Wegiel, J., Dowjat, K., Kaczmarski, W., et al. (2008). The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Acta Neuropathologica, 116, 391-407.
    • (2008) Acta Neuropathologica , vol.116 , pp. 391-407
    • Wegiel, J.1    Dowjat, K.2    Kaczmarski, W.3
  • 67
    • 0032146236 scopus 로고    scopus 로고
    • The amphiphysin family of proteins and their role in endocytosis at the synapse
    • Wigge, P. & McMahon, H. T. (1998). The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends in Neurosciences, 21, 339-344.
    • (1998) Trends in Neurosciences , vol.21 , pp. 339-344
    • Wigge, P.1    Mc Mahon, H.T.2
  • 69
    • 37549052020 scopus 로고    scopus 로고
    • Down syndrome: From pathology to pathogenesis
    • J. A. Rondal & J. Perera (eds.). Down syndrome series. London: Wiley
    • Wisniewski, K. E., Kida, E., Golabek, A. A., et al. (2006). Down syndrome: From pathology to pathogenesis. In J. A. Rondal & J. Perera (eds.), Down Syndrome: Neurobehavioral Specificity. Down syndrome series, pp. 17-33. London: Wiley.
    • (2006) Down Syndrome: Neurobehavioral Specificity , pp. 17-33
    • Wisniewski, K.E.1    Kida, E.2    Golabek, A.A.3
  • 70
    • 0001865721 scopus 로고
    • Neuronal density and synaptogenesis in the postnatal stage of brain maturation in Down syndrome
    • C. J. Epstein (ed). New York: Raven Press
    • Wisniewski, K. E., Laure-Kamnionowska, M., Connell, F., Wen, G. Y. (1986). Neuronal density and synaptogenesis in the postnatal stage of brain maturation in Down syndrome. In C. J. Epstein (ed.), The Neurobiology of Down Syndrome, pp. 29-44. New York: Raven Press.
    • (1986) The Neurobiology of Down Syndrome , pp. 29-44
    • Wisniewski, K.E.1    Laure-Kamnionowska, M.2    Connell, F.3    Wen, G.Y.4
  • 71
    • 77949678789 scopus 로고    scopus 로고
    • DyrklA overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells
    • Yabut, O., Domogauer, J., d'Arcangelo, G. (2010). DyrklA overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. Journal of Neuroscience, 30, 4004-4014.
    • (2010) Journal of Neuroscience , vol.30 , pp. 4004-4014
    • Yabut, O.1    Domogauer, J.2    Darcangelo, G.3
  • 72
    • 77954461956 scopus 로고    scopus 로고
    • A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
    • Yu, T., Li, Z., Jia, Z., et al. (2010). A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Human Molecular Genetics, 5, 2780-2791.
    • (2010) Human Molecular Genetics , vol.5 , pp. 2780-2791
    • Yu, T.1    Li, Z.2    Jia, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.