Expansion of CD4+CD25-GITR+ regulatory t-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: Correlation with disease activity

Reumatismo

Volumn 64, Issue 5, 2012, Pages 293-298

  Alunno, A ^a   Nocentini, G ^a   Bistoni, O ^a   Petrillo, M G ^a   Bartoloni Bocci, E ^a   Ronchetti, S ^a   Lo Vaglio, E ^a   Riccardi, C ^a   Gerli, R ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

FoxP3; GITR; Regulatory T cells; Sj gren's syndrome

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL EXPANSION; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; PHENOTYPE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; SJOEGREN SYNDROME; T LYMPHOCYTE SUBPOPULATION;

EID: 84871465146     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: 10.4081/reumatismo.2012.293     Document Type: Article

References (24)

1. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α chain (CD25), breakdown of a single mechanism of self tolerance causes various autoimmune disease. J Immunol. 1995; 155: 1151-64.
2. Dieckmann D, Plottner H, Berchtold S, et al. Ex vivo isolation of CD4+CD25+ T cells with regulatory properties from human blood. J Exp Med. 2001; 193: 1303-10.
3. Chatila TA, Blaeser F, Ho N, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest. 2000; 106: 75-81
4. Gambineri E, Torgerson TR, Ochs TD. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FoxP3, a critical regulator of T-cell homeostasis. Curr Op Rheumatol. 2003; 15: 430-5.
5. Fontenot JD, Gavin MA, Rudensky AY. FoxP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003; 4: 330-6.
6. Feuerer M, Hill JA, Mathis D, Benoist C. FoxP3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009; 10: 689-95.
7. Nocentini G, Giunchi L, Ronchetti S, et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA. 1997; 4: 6216-21.
8. Klein S, Kretz CC, Krammer PH, Kuhn A. CD127(low/-) and FoxP3+ expression levels characterize different regulatory T cell populations in human peripheral blood. J Invest Dermatol. 2010; 130: 492-9.
9. Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25-naïve T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor FoxP3. J Exp Med. 2003; 198: 1875-86.
10. Dieckmann D, Bruett CH, Ploettner H, et al. Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact independent type 1 like regulatory cells. J Exp Med. 2002; 196: 247-53.
11. Kelchtermans H, De Klerck B, Mitera T, et al. Defective CD4+CD25+ regulatory T cell functioning in collagen induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ. Arthritis Res Ther. 2005; 7: 402-15.
12. Morgan ME, Sutmuller RPM, Witteveen HJ, et al. CD25 cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum. 2003; 48: 1452-60.
13. Morgan ME, Flierman R, van Duivenvoorde LM, et al. Effective treatment of collagen-induced arthritis by adoptive transfer of CD25 regulatory T cells. Arthritis Rheum. 2005; 52: 2212-21.
14. Cuzzocrea S, Ayroldi E, Di Paola R, et al. Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis. FASEB J. 2005; 19: 1253-65.
15. van Amelsfort JMR, van Roon JAG, Noordegraaf M, et al. Proinflammatory mediator-induced reversal of CD4+CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum. 2007; 56: 732-42.
16. Gottenberg JE, Lavie F, Abbed K, et al. CD4C-D25high regulatory T cells are not impaired in patients with primary Sjögren'a syndrome. J Autoimmunity. 2005; 24: 235-42.
17. Christodoulou MI, Kapsogeorgou EK, Moutsopoulos NM, Moutsopoulos HM. Foxp3+ T-Regulatory cells in Sjögren's syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am J Pathol. 2008; 173: 1389.
18. Sarigul M, Yazisiz V, Bassorgun CI, et al. The numbers of FoxP3+ Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome. Lupus. 2010; 19: 138.
19. Seror R, Ravaud P, Bowman SJ, et al., On behalf of the EULAR Sjogren's task force. EULAR Sjogren's syndrome disease activity index (ESSDAI) Development of a consensus systemic disease activity index in primary Sjogren's syndrome. Ann Rheum Dis. 2011; 70.
20. Alunno A, Nocentini G, Bistoni O, et al. Glucocorticoid-induced TNFR-related protein (GITR) come marker di cellule T regolatorie umane: espansione della sottopopolazione cellulare GITR+CD25-in pazienti affetti da lupus eritematoso sistemico. Reumatismo. 2010; 62: 195.
21. Behrens F, Himsel A, Rehart S, et al. Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis. 2007; 66: 1151-6.
22. Liu MF, Wang CR, Fung LL, et al. The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol. 2005; 62: 312-7.
23. Jiao Z, Wang W, Jia R, et al. Accumulation of FoxP3-expressing CD4+CD25+ T cells with a distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol. 2007; 36: 428-33.
24. Alunno A, Bartoloni Bocci E, Nocentini G, et al. Role of regulatory T cells in rheumatoid arthritis: fact and hypothesis. Autoimmunity Highlights. 2010; 1: 45-51.