The adenosine A3 receptor agonist Cl-IB-MECA induces cell death through Ca2+/ROS-dependent down regulation of ERK and akt in A172 human glioma cells

Neurochemical Research

Volumn 37, Issue 12, 2012, Pages 2667-2677

  Kim, Thae Hyun ^a   Kim, Yong Keun ^a   Woo, Jae Suk ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Adenosine A3 receptor; Apoptosis; CI IB MECA; ERK Akt; Glioma cells; ROS

Indexed keywords

2 CHLORO 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ACETYLCYSTEINE; ADENOSINE A3 RECEPTOR AGONIST; ANTINEOPLASTIC AGENT; CALCIUM ION; CASPASE 3; CASPASE INHIBITOR; EGTAZIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SURVIVIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOSINE; ADENOSINE A3 RECEPTOR AGONISTS; BASE SEQUENCE; BLOTTING, WESTERN; CALCIUM; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PRIMERS; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84871455601     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0855-5     Document Type: Article

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