메뉴 건너뛰기




Volumn 5, Issue 5, 2012, Pages 1185-1190

Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways

Author keywords

Akt signaling pathway; ERK MAPK signaling pathway; Ginseng pectin; Neuronal protection; Oxidative stress

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; BETA TUBULIN; GINSENG PECTIN; GINSENOSIDE RB 1; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PECTIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84863251096     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.811     Document Type: Article
Times cited : (20)

References (25)
  • 1
    • 3142514196 scopus 로고    scopus 로고
    • Oxidative stress in neurodegeneration: Cause or consequence?
    • Andersen JK: Oxidative stress in neurodegeneration: cause or consequence? Nat Rev Neurosci 10: S18-S25, 2004.
    • (2004) Nat Rev Neurosci , vol.10
    • Andersen, J.K.1
  • 2
    • 0034923434 scopus 로고    scopus 로고
    • Oxidative damage is the earliest event in Alzheimer disease
    • Akihiko NM, George P, Gjumrakch A, et al: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60: 759-767, 2001.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 759-767
    • Akihiko, N.M.1    George, P.2    Gjumrakch, A.3
  • 4
  • 5
    • 34249747700 scopus 로고    scopus 로고
    • Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    • DOI 10.1016/j.ejphar.2007.01.089, PII S0014299907001707
    • Zhang L, Yu H, Sun Y, et al: Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol 564: 18-25, 2007. (Pubitemid 46946844)
    • (2007) European Journal of Pharmacology , vol.564 , Issue.1-3 , pp. 18-25
    • Zhang, L.1    Yu, H.2    Sun, Y.3    Lin, X.4    Chen, B.5    Tan, C.6    Cao, G.7    Wang, Z.8
  • 6
    • 33644544121 scopus 로고    scopus 로고
    • Antioxidant effects of ginsenoside Re in cardiomyocytes
    • Xie JT, Shao ZH, Vanden Hoek TL, et al: Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol 532: 201-207, 2006.
    • (2006) Eur J Pharmacol , vol.532 , pp. 201-207
    • Xie, J.T.1    Shao, Z.H.2    Vanden Hoek, T.L.3
  • 7
    • 1842767270 scopus 로고    scopus 로고
    • Glioma cell antioxidant capacity relative to reactive oxygen species produced by dopamine
    • DOI 10.1002/jat.954
    • Mazzio EA and Soliman KFA: Glioma cell antioxidant capacity relative to reactive oxygen species produced by dopamine. J Applied Toxicol 24: 99-106, 2004. (Pubitemid 38477570)
    • (2004) Journal of Applied Toxicology , vol.24 , Issue.2 , pp. 99-106
    • Mazzio, E.A.1    Soliman, K.F.A.2
  • 8
    • 75749093639 scopus 로고    scopus 로고
    • ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against Glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD
    • Shen JF, Wu YL, Xu JY, et al: ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against Glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Biochem Mol Biol 51: 2010.
    • (2010) Biochem Mol Biol , vol.51
    • Shen, J.F.1    Wu, Y.L.2    Xu, J.Y.3
  • 9
    • 80053643156 scopus 로고    scopus 로고
    • Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling
    • Xu JD, Xilouri M, Bruban J, et al: Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. Neurobiol Aging 32: 2326.e5-e16, 2011.
    • (2011) Neurobiol Aging , vol.32
    • Xu, J.D.1    Xilouri, M.2    Bruban, J.3
  • 10
    • 79551650931 scopus 로고    scopus 로고
    • Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle
    • Nayak GH, Prentice HM and Milton SL: Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle. J Cerebral Blood Flow Metab 31: 467-475, 2011.
    • (2011) J Cerebral Blood Flow Metab , vol.31 , pp. 467-475
    • Nayak, G.H.1    Prentice, H.M.2    Milton, S.L.3
  • 11
    • 80051473568 scopus 로고    scopus 로고
    • Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    • Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB and Kiyatkin A: Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal 23: 1794-1805, 2011.
    • (2011) Cell Signal , vol.23 , pp. 1794-1805
    • Aksamitiene, E.1    Achanta, S.2    Kolch, W.3    Kholodenko, B.N.4    Hoek, J.B.5    Kiyatkin, A.6
  • 12
    • 39649122125 scopus 로고    scopus 로고
    • Structural identification of ginseng polysaccharides and testing of their antioxidant activities
    • Luo DH and Fang BS: Structural identification of ginseng polysaccharides and testing of their antioxidant activities. Carbohyd Polym 72: 376-381, 2008.
    • (2008) Carbohyd Polym , vol.72 , pp. 376-381
    • Luo, D.H.1    Fang, B.S.2
  • 13
    • 51349106992 scopus 로고    scopus 로고
    • Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer
    • CHOI KT
    • CHOI KT: Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer. Acta Pharmacol Sin 29: 1109-1118, 2008.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1109-1118
  • 14
    • 4344622460 scopus 로고    scopus 로고
    • 1 effects on mesencephalic dopaminergic cells stressed with glutamate
    • DOI 10.1016/j.brainres.2004.06.030, PII S000689930400962X
    • Radad K, Gille G, Moldzio R, Saito H and Rausch WD: Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 1021: 41-53, 2004. (Pubitemid 39158655)
    • (2004) Brain Research , vol.1021 , Issue.1 , pp. 41-53
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Rausch, W.-D.5
  • 15
    • 34548130846 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats
    • DOI 10.1016/j.brainres.2007.06.024, PII S0006899307013509
    • Yuan QL, Yang CX, Xu P, et al: Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats. Brain Res 1167: 1-12, 2007. (Pubitemid 47302431)
    • (2007) Brain Research , vol.1167 , Issue.1 , pp. 1-12
    • Yuan, Q.-L.1    Yang, C.-X.2    Xu, P.3    Gao, X.-Q.4    Deng, L.5    Chen, P.6    Sun, Z.-L.7    Chen, Q.-Y.8
  • 16
    • 0842331895 scopus 로고    scopus 로고
    • The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons
    • DOI 10.1016/j.neuint.2003.08.013
    • Gerling N, Culmsee C, Klumpp S and Krieglstein J: The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons. Neurochem Int 44: 505-520, 2004. (Pubitemid 38183301)
    • (2004) Neurochemistry International , vol.44 , Issue.7 , pp. 505-520
    • Gerling, N.1    Culmsee, C.2    Klumpp, S.3    Krieglstein, J.4
  • 17
    • 0036180097 scopus 로고    scopus 로고
    • Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in Vitro
    • DOI 10.1006/exnr.2001.7841
    • Liao B, Newmark H and Zhou R: Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exper Neurol 173: 224-234, 2002. (Pubitemid 34151374)
    • (2002) Experimental Neurology , vol.173 , Issue.2 , pp. 224-234
    • Liao, B.1    Newmark, H.2    Zhou, R.3
  • 18
  • 19
    • 77954462433 scopus 로고    scopus 로고
    • The inhibitory effect of ginseng pectin on L-929 cell migration
    • Fan YY, Cheng HR, Liu D, et al: The inhibitory effect of ginseng pectin on L-929 cell migration. Arch Pharmacol Res 33: 681-689, 2010.
    • (2010) Arch Pharmacol Res , vol.33 , pp. 681-689
    • Fan, Y.Y.1    Cheng, H.R.2    Liu, D.3
  • 20
    • 77953131062 scopus 로고    scopus 로고
    • Relationship of the inhibition of cell migration with the structure of ginseng pectic polysaccharides
    • Fan YY, Cheng HR, Li SS, et al: Relationship of the inhibition of cell migration with the structure of ginseng pectic polysaccharides. Carbohyd Polym 81: 340-347, 2010.
    • (2010) Carbohyd Polym , vol.81 , pp. 340-347
    • Fan, Y.Y.1    Cheng, H.R.2    Li, S.S.3
  • 21
    • 77954951295 scopus 로고    scopus 로고
    • Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C.A. Meyer
    • Wang J, Li SS, Fan YY, et al: Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C.A. Meyer. J Ethnopharmacol 130: 421-423, 2010.
    • (2010) J Ethnopharmacol , vol.130 , pp. 421-423
    • Wang, J.1    Li, S.S.2    Fan, Y.Y.3
  • 22
    • 79952252180 scopus 로고    scopus 로고
    • Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells
    • Cheng HR, Li SS, Fan YY, et al: Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells. Med Oncol 28: 175-181, 2010.
    • (2010) Med Oncol , vol.28 , pp. 175-181
    • Cheng, H.R.1    Li, S.S.2    Fan, Y.Y.3
  • 23
    • 67349202467 scopus 로고    scopus 로고
    • Total fractionation and characterization of the water-soluble polysaccharides is isolated from Panax ginseng C. A. Meyer
    • Zhang X, Yu L, Bi HT, et al: Total fractionation and characterization of the water-soluble polysaccharides is isolated from Panax ginseng C. A. Meyer. Carbohyd Polym 77: 544-552, 2009.
    • (2009) Carbohyd Polym , vol.77 , pp. 544-552
    • Zhang, X.1    Yu, L.2    Bi, H.T.3
  • 24
    • 33847209168 scopus 로고    scopus 로고
    • Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats
    • Kamada H, Nito C, Endo H and Chan PH: Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats. J Cerebr Blood F Met 27: 521-533, 2007.
    • (2007) J Cerebr Blood F Met , vol.27 , pp. 521-533
    • Kamada, H.1    Nito, C.2    Endo, H.3    Chan, P.H.4
  • 25
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenburg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenburg, M.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.