Development of an analytical approach for identification and quantification of 5-α-androst-16-en-3-one in human milk

Steroids

Volumn 78, Issue 2, 2013, Pages 156-160

  Hartmann, Constanze ^a   Mayenzet, Fabienne ^b   Larcinese, Jean Paul ^b   Haefliger, Olivier P ^b   Buettner, Andrea ^a,c   Starkenmann, Christian ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Email:   (Switzerland)

^c FRAUNHOFER INSTITUTE FOR PROCESS ENGINEERING AND PACKAGING IVV   (Germany)

Author keywords

5 Androst 16 en 3 one; Breast milk; GC MS; Gel permeation chromatography; Stable isotope dilution assay

Indexed keywords

5ALPHA ANDROST 16 EN 3 ONE; ANDROGEN; SILICA GEL; STEROID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREAST MILK; COLUMN CHROMATOGRAPHY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; LIMIT OF QUANTITATION; MASS FRAGMENTOGRAPHY; VOLUNTEER;

ANDROSTENES; CHROMATOGRAPHY, GEL; DEUTERIUM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; ISOTOPE LABELING; MILK, HUMAN; STAINING AND LABELING;

EID: 84871446476     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.11.005     Document Type: Article

References (34)

1. P.M. Bingham, D. Stevens-Tuttle, E. Lavin, and T. Acree Odorants in breast milk Arch Pediatr Adolesc Med 157 2003 1031
2. A. Buettner A selective and sensitive approach to characterize oclour-active and volatile constituents in small-scale human milk samples Flavour Frag J 22 2007 465 473
3. H. Hausner, M. Philipsen, T.H. Skov, M.A. Petersen, and W.L.P. Bredie Characterization of the volatile composition and variations between infant formulas and mother's milk Chemosens Percept 2 2009 79 93
4. M. Shimoda, T. Yoshimura, H. Ishikawa, I. Hayakawa, and Y. Osajima Volatile compounds in human milk J Fac Agric Kyushu Univ 45 2000 199 206
5. J. Spitzer, and A. Buettner Characterization of aroma changes in human milk during storage at-19 degrees. C Food Chem 120 2010 240 246
6. F. Fenaille, P. Visani, R. Fumeaux, C. Milo, and P.A. Guy Comparison of mass spectrometry-based electronic nose and solid phase MicroExtraction gas chromatography mass spectrometry technique to assess infant formula oxidation J Agric Food Chem 51 2003 2790 2796
7. S.M. van Ruth, V. Floris, and S. Fayoux Characterisation of the volatile profiles of infant formulas by proton transfer reaction-mass spectrometry and gas chromatography-mass spectrometry Food Chem 98 2006 343 350
8. S. Bird, and D.B. Gower The validation and use of a radioimmunoassay for 5α-androst-16-en-3-one in human axillary collections J Steroid Biochem 14 1981 213 219
9. R. Claus, and W. Alsing Occurence of 5-alpha-androste-16-en-3-one, a boar pheromone, in man and its relationship to testosterone J Endocrinol 68 1976 483 484
10. D.B. Gower, K.T. Holland, A.I. Mallet, P.J. Rennie, and W.J. Watkins Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions- interconversions of 16-androstenes by the axillary microflora- a mechanism for axillary odor production in man Journal of Steroid Biochemistry and Mol Biol 48 1994 409 418
11. S. Bird, and D.B. Gower Estimation of the odorous steroid 5-alpha-androst-16-en-3-one in human saliva Experientia 39 1983 790 791
12. T.K. Kwan, D.J.H. Trafford, H.L.J. Makin, A.I. Mallet, and D.B. Gower GC-MS studies of 16-androstenes and other C19 steroids in human semen J Steroid Biochem Mol Biol 43 1992 549 556
13. E.E. Filsinger, and W.C. Monte Sex history, menstrual cycle, and psychophysical ratings of alpha androstenone, a possible human sex pheromone J Sex Res 22 1986 243 248
14. G. Karl 5-androst-16en-3-on: A male pheromone? A brief report Ethol Sociobiol 14 1993 201 207
15. M.D. Kirk-Smith, and D.A. Booth Effect of androstenone on choice of location in others' presence H. Van der Starre, Olfaction and taste VII 1980 IRL Press London
16. K. Lübke, S. Schablitzky, and B. Pause Male sexual orientation affects sensitivity to androstenone Chemosens Percept. 2 2009 154 160
17. B.M. Pause Are androgen steroids acting as pheromones in humans? Physiol Behav 83 2004 21 29
18. R.G. Jensen Lipids in human milk Lipids 34 1999 1243 1271
19. M.A. Magard, H.E.B. Berg, V. Tagesson, M.L.G. Jaremo, L.L.H. Karlsson, and L.J.E. Mathiasson Determination of androstenone in pig fat using supercritical-fluid extraction and gas chromatography-mass spectrometry J Agric Food Chem 43 1995 114 120
20. J. Fischer, P.W. Elsinghorst, M. Buecking, E. Tholen, B. Petersen, and M. Wuest Development of a candidate reference method for the simultaneous quantitation of the boar taint compounds androstenone, 3α-androstenol, 3β-androstenol, skatole, and indole in pig fat by means of stable isotope dilution analysis-headspace solid-phase microextraction-gas chromatography/mass spectrometry Anal Chem 83 2011 6785 6791
21. J. Hansenmoller Rapid high-performance liquid-chromatographic method for simultaneous determination of androstenone, skatole and indole in back fat from pigs J Chromatogr B:-Biomed Appl 661 1994 219 230
22. G. Chen, L. Ren, S.M. Yang, J. Qiu, A. Kamal-Eldin, and K. Lundstroem Determination of androstenone levels in porcine plasma by LC-MS/MS Food Chem 122 2011 1278 1282
23. S. Sandgruber, D. Much, U. Amann-Gassner, H. Hauner, and A. Buettner Sensory and molecular characterisation of the protective effect of storage at -80 degrees C on the odour profiles of human milk Food Chem 130 2012 236 242
24. S. Sandgruber, D. Much, U. Amann-Gassner, H. Hauner, and A. Buettner Sensory and molecular characterisation of human milk odour profiles after maternal fish oil supplementation during pregnancy and breastfeeding Food Chem 128 2011 485 494
25. J. Spitzer, S. Doucet, and A. Buettner The influence of storage conditions on flavour changes in human milk Food Qual Prefer 21 2010 998 1007
26. E. Perel, K.J. Stolee, L. Kharlip, M.E. Blackstein, and D.W. Killinger Androstenedione metabolism in ephithelial-cells derived from early lactation milk Steroids 42 1983 389 399
27. J.E. Amoore Specific anosmia and the concept of primary odors Chem Senses 2 1977 267 281
28. E.A. Bremner, J.D. Mainland, R.M. Khan, and N. Sobel The prevalence of androstenone anosmia Chem Senses 28 2003 423 432
29. S. Doucet, C. Hartmann, R. Dittrich, B. Schaal, and A. Buettner Do overlapping odor costituents explain undifferebtiated neonatal attraction to amniotic fluid and human milk? T. Hofmann, W. Meyerhof, P. Schieberle, Advances and challenges in flavour chemistry, Proceedings of the 9th Wartburg Symposium on Flavor Chemistry & Biology 2010 Eigenverlag Deutsche Forschungsanstalt für Lebensmittelchemie Freising 39 44
30. H.J. Schmidt, and G.K. Beauchamp Adult-like odor preferences and aversions in three-year-old children Child Dev 59 1988 1136 1143
31. Buettner A. Aroma release and perception during consumption of food taking into account physilogical aspects. Munich, Germany: Habilitationsschrift (Thesis of habilitation), Verlag Dr. Hut; 2007.
32. B. Schaal, G. Coureaud, D. Langlois, C. Ginies, E. Semon, and G. Perrier Chemical and behavioural characterization of the rabbit mammary pheromone Nature 424 2003 68 72
33. L. Marlier, and B. Schaal Human newborns prefer human milk: conspecific milk odor is attractive without postnatal exposure Child Dev 76 2005 155 168
34. L. Marlier, B. Schaal, and R. Soussignan Bottle-fed neonates prefer an odor experienced in utero to an odor experienced postnatally in the feeding context Dev Psychobiol 33 1998 133 145