메뉴 건너뛰기




Volumn 28, Issue 5, 2012, Pages 641-648

Metabolomics: A novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer's disease

Author keywords

Alzheimer's disease; Biomarkers; Metabolomics

Indexed keywords

CHOLESTEROL; MONOAMINE;

EID: 84871407901     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-012-1272-0     Document Type: Review
Times cited : (46)

References (48)
  • 2
  • 3
    • 78751668879 scopus 로고    scopus 로고
    • Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1
    • Mayeux R, Reitz C, Brickman AM, Haan MN, Manly JJ, Glymour MM, et al. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1. Alzheimers Dement 2011, 7: 15-34.
    • (2011) Alzheimers Dement , vol.7 , pp. 15-34
    • Mayeux, R.1    Reitz, C.2    Brickman, A.M.3    Haan, M.N.4    Manly, J.J.5    Glymour, M.M.6
  • 5
    • 79956076567 scopus 로고    scopus 로고
    • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7: 257-262.
    • (2011) Alzheimers Dement , vol.7 , pp. 257-262
    • Jack, Jr.C.R.1    Albert, M.S.2    Knopman, D.S.3    McKhann, G.M.4    Sperling, R.A.5    Carrillo, M.C.6
  • 7
    • 79958792912 scopus 로고    scopus 로고
    • Clinical amyloid imaging in Alzheimer's disease
    • Herholz K, Ebmeier K. Clinical amyloid imaging in Alzheimer's disease. Lancet Neurol 2011, 10: 667-670.
    • (2011) Lancet Neurol , vol.10 , pp. 667-670
    • Herholz, K.1    Ebmeier, K.2
  • 8
    • 79958777483 scopus 로고    scopus 로고
    • The search for neuroimaging biomarkers of Alzheimer's disease with advanced MRI techniques
    • Li TQ, Wahlund LO. The search for neuroimaging biomarkers of Alzheimer's disease with advanced MRI techniques. Acta Radiol 2011, 52: 211-222.
    • (2011) Acta Radiol , vol.52 , pp. 211-222
    • Li, T.Q.1    Wahlund, L.O.2
  • 9
    • 78650420189 scopus 로고    scopus 로고
    • Identifying and validating biomarkers for Alzheimer'sdisease
    • Humpel C. Identifying and validating biomarkers for Alzheimer'sdisease. Trends Biotechnol 2011, 29: 26-32.
    • (2011) Trends Biotechnol , vol.29 , pp. 26-32
    • Humpel, C.1
  • 11
    • 78650403081 scopus 로고    scopus 로고
    • Reimagining Alzheimer's disease-an age-based hypothesis
    • Herrup K. Reimagining Alzheimer's disease-an age-based hypothesis. J Neurosci 2010, 30: 16755-16762.
    • (2010) J Neurosci , vol.30 , pp. 16755-16762
    • Herrup, K.1
  • 12
    • 77953330985 scopus 로고    scopus 로고
    • A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: Possible relevance for Alzheimer's disease
    • Agnati LF, Guidolin D, Baluska F, Leo G, Barlow PW, Carone C, et al. A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease. Curr Alzheimer Res 2010, 7: 307-322.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 307-322
    • Agnati, L.F.1    Guidolin, D.2    Baluska, F.3    Leo, G.4    Barlow, P.W.5    Carone, C.6
  • 13
    • 77954556005 scopus 로고    scopus 로고
    • Vascular and psychosocial factors in Alzheimer's disease: Epidemiological evidence toward intervention
    • Qiu C, Xu W, Fratiglioni L. Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention. J Alzheimers Dis 2010, 20: 689-697.
    • (2010) J Alzheimers Dis , vol.20 , pp. 689-697
    • Qiu, C.1    Xu, W.2    Fratiglioni, L.3
  • 14
    • 79955521915 scopus 로고    scopus 로고
    • Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease
    • Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, et al. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 2011, 76: 1485-1491.
    • (2011) Neurology , vol.76 , pp. 1485-1491
    • Li, J.1    Wang, Y.J.2    Zhang, M.3    Xu, Z.Q.4    Gao, C.Y.5    Fang, C.Q.6
  • 16
    • 78049416309 scopus 로고    scopus 로고
    • Analytical approaches to metabolomics and applications to systems biology
    • Wang JH, Byun J, Pennathur S. Analytical approaches to metabolomics and applications to systems biology. Semin Nephrol 2010, 30: 500-511.
    • (2010) Semin Nephrol , vol.30 , pp. 500-511
    • Wang, J.H.1    Byun, J.2    Pennathur, S.3
  • 18
    • 80052945596 scopus 로고    scopus 로고
    • Urine metabolomics for kidney cancer detection and biomarker discovery
    • Ganti S, Weiss RH. Urine metabolomics for kidney cancer detection and biomarker discovery. Urol Oncol 2011, 29: 551-557.
    • (2011) Urol Oncol , vol.29 , pp. 551-557
    • Ganti, S.1    Weiss, R.H.2
  • 19
    • 80655131103 scopus 로고    scopus 로고
    • The cardiovascular risk of healthy individuals studied by NMR metabonomics of plasma samples
    • Bernini P, Bertini I, Luchinat C, Tenori L, Tognaccini A. The cardiovascular risk of healthy individuals studied by NMR metabonomics of plasma samples. J Proteome Res 2011, 10: 4983-4992.
    • (2011) J Proteome Res , vol.10 , pp. 4983-4992
    • Bernini, P.1    Bertini, I.2    Luchinat, C.3    Tenori, L.4    Tognaccini, A.5
  • 20
    • 77956286242 scopus 로고    scopus 로고
    • Magnetic resonance metabolomics of intact tissue: A biotechnological tool in cancer diagnostics and treatment evaluation
    • Bathen TF, Sitter B, Sjobakk TE, Tessem MB, Gribbestad IS. Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluation. Cancer Res 2010, 70: 6692-6696.
    • (2010) Cancer Res , vol.70 , pp. 6692-6696
    • Bathen, T.F.1    Sitter, B.2    Sjobakk, T.E.3    Tessem, M.B.4    Gribbestad, I.S.5
  • 21
    • 84866728483 scopus 로고    scopus 로고
    • The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics (1) H highresolution magic angle spinning NMR spectroscopy
    • doi: 10.1002/mrm.24110
    • Benahmed MA, Santelmo N, Elbayed K, Frossard N, Noll E, Canuet M, et al. The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics (1) H highresolution magic angle spinning NMR spectroscopy. Magn Reson Med 2011, doi: 10.1002/mrm.24110.
    • (2011) Magn Reson Med
    • Benahmed, M.A.1    Santelmo, N.2    Elbayed, K.3    Frossard, N.4    Noll, E.5    Canuet, M.6
  • 22
    • 83455203337 scopus 로고    scopus 로고
    • Modern analytical techniques in metabolomics analysis
    • Zhang A, Sun H, Wang P, Han Y, Wang X. Modern analytical techniques in metabolomics analysis. Analyst 2012, 137: 293-300.
    • (2012) Analyst , vol.137 , pp. 293-300
    • Zhang, A.1    Sun, H.2    Wang, P.3    Han, Y.4    Wang, X.5
  • 23
    • 80051704393 scopus 로고    scopus 로고
    • Quantitative metabolomics based on gas chromatography mass spectrometry: Status and perspectives
    • Koek MM, Jellema RH, van der Greef J, Tas AC, Hankemeier T. Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics 2011, 7: 307-328.
    • (2011) Metabolomics , vol.7 , pp. 307-328
    • Koek, M.M.1    Jellema, R.H.2    Van Der Greef, J.3    Tas, A.C.4    Hankemeier, T.5
  • 25
    • 83455208035 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies
    • Wang X, Sun H, Zhang A, Wang P, Han Y. Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies. J Sep Sci 2011, 34: 3451-3459.
    • (2011) J Sep Sci , vol.34 , pp. 3451-3459
    • Wang, X.1    Sun, H.2    Zhang, A.3    Wang, P.4    Han, Y.5
  • 26
    • 79955462577 scopus 로고    scopus 로고
    • Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples
    • Barbas C, Moraes EP, Villasenor A. Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples. J Pharm Biomed Anal 2011, 55: 823-831.
    • (2011) J Pharm Biomed Anal , vol.55 , pp. 823-831
    • Barbas, C.1    Moraes, E.P.2    Villasenor, A.3
  • 27
    • 73349091531 scopus 로고    scopus 로고
    • Two-dimensional J-resolved NMR spectroscopy: Review of a key methodology in the metabolomics toolbox
    • Ludwig C, Viant MR. Two-dimensional J-resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox. Phytochem Anal 2010, 21: 22-32.
    • (2010) Phytochem Anal , vol.21 , pp. 22-32
    • Ludwig, C.1    Viant, M.R.2
  • 28
    • 79951726798 scopus 로고    scopus 로고
    • Semi-automated non-target processing in GC x GC-MS metabolomics analysis: Applicability for biomedical studies
    • Koek MM, van der Kloet FM, Kleemann R, Kooistra T, Verheij ER, Hankemeier T. Semi-automated non-target processing in GC x GC-MS metabolomics analysis: applicability for biomedical studies. Metabolomics 2011, 7: 1-14.
    • (2011) Metabolomics , vol.7 , pp. 1-14
    • Koek, M.M.1    Van Der Kloet, F.M.2    Kleemann, R.3    Kooistra, T.4    Verheij, E.R.5    Hankemeier, T.6
  • 29
    • 84856217217 scopus 로고    scopus 로고
    • From single to multiple microcoil flow probe NMR and related capillary techniques: A review
    • Gokay O, Albert K. From single to multiple microcoil flow probe NMR and related capillary techniques: a review. Anal Bioanal Chem 2012, 402: 647-669.
    • (2012) Anal Bioanal Chem , vol.402 , pp. 647-669
    • Gokay, O.1    Albert, K.2
  • 30
  • 32
    • 84871291341 scopus 로고    scopus 로고
    • Potential metabolite markers of schizophrenia
    • doi: 10.1038/mp.2011.131
    • Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, et al. Potential metabolite markers of schizophrenia. Mol Psychiatry 2011, doi: 10.1038/mp.2011.131.
    • (2011) Mol Psychiatry
    • Yang, J.1    Chen, T.2    Sun, L.3    Zhao, Z.4    Qi, X.5    Zhou, K.6
  • 34
    • 0027505011 scopus 로고
    • Transgenic mice expressing human β-APP751, but not mice expressing β-APP695, display early Alzheimer's disease-like histopathology
    • DOI 10.1111/j.1749-6632.1993.tb23056.x
    • Higgins LS, Catalano R, Quon D, Cordell B. Transgenic mice expressing human beta-APP751, but not mice expressing beta- APP695, display early Alzheimer's disease-like histopathology. Ann N Y Acad Sci 1993, 695: 224-227. (Pubitemid 23348265)
    • (1993) Annals of the New York Academy of Sciences , vol.695 , pp. 224-227
    • Higgins, L.S.1    Catalano, R.2    Quon, D.3    Cordell, B.4
  • 35
    • 77953124257 scopus 로고    scopus 로고
    • A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease
    • Salek RM, Xia J, Innes A, Sweatman BC, Adalbert R, Randle S, et al. A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochem Int 2010, 56: 937-947.
    • (2010) Neurochem Int , vol.56 , pp. 937-947
    • Salek, R.M.1    Xia, J.2    Innes, A.3    Sweatman, B.C.4    Adalbert, R.5    Randle, S.6
  • 39
    • 25844496169 scopus 로고    scopus 로고
    • Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease
    • DOI 10.2174/1567205052772786
    • Han X. Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: implication of the role of lipids in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res 2005, 2: 65-77. (Pubitemid 41389260)
    • (2005) Current Alzheimer Research , vol.2 , Issue.1 , pp. 65-77
    • Han, X.1
  • 41
    • 77954315742 scopus 로고    scopus 로고
    • Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/ mass spectrometry
    • Li NJ, Liu WT, Li W, Li SQ, Chen XH, Bi KS, et al. Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/ mass spectrometry. Clin Biochem 2010, 43: 992-997.
    • (2010) Clin Biochem , vol.43 , pp. 992-997
    • Li, N.J.1    Liu, W.T.2    Li, W.3    Li, S.Q.4    Chen, X.H.5    Bi, K.S.6
  • 42
    • 78649980497 scopus 로고    scopus 로고
    • Lipidomics: New tools and applications
    • Wenk MR. Lipidomics: new tools and applications. Cell 2010, 143: 888-895.
    • (2010) Cell , vol.143 , pp. 888-895
    • Wenk, M.R.1
  • 43
    • 79960114429 scopus 로고    scopus 로고
    • Metabolomics in early Alzheimer's disease: Identification of altered plasma sphingolipidome using shotgun lipidomics
    • Han X, Rozen S, Boyle SH, Hellegers C, Cheng H, Burke JR, et al. Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS One 2011, 6: e21643.
    • (2011) PLoS One , vol.6
    • Han, X.1    Rozen, S.2    Boyle, S.H.3    Hellegers, C.4    Cheng, H.5    Burke, J.R.6
  • 44
    • 84859498953 scopus 로고    scopus 로고
    • Serum fatty acid profiles using GC-MS and multivariate statistical analysis: Potential biomarkers of Alzheimer's disease
    • Wang DC, Sun CH, Liu LY, Sun XH, Jin XW, Song WL, et al. Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. Neurobiol Aging 2012, 33: 1057-1066.
    • (2012) Neurobiol Aging , vol.33 , pp. 1057-1066
    • Wang, D.C.1    Sun, C.H.2    Liu, L.Y.3    Sun, X.H.4    Jin, X.W.5    Song, W.L.6
  • 45
    • 80053928598 scopus 로고    scopus 로고
    • Cholesterol level and statin use in alzheimer disease: I review of epidemiological and preclinical studies
    • Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol 2011, 68: 1239-1244.
    • (2011) Arch Neurol , vol.68 , pp. 1239-1244
    • Shepardson, N.E.1    Shankar, G.M.2    Selkoe, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.