The γ-Secretase Blocker DAPT Reduces the Permeability of the Blood-Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia

CNS Neuroscience and Therapeutics

Volumn 19, Issue 1, 2013, Pages 53-60

  Zhang, Gen Sheng ^a,b   Tian, Yun ^a   Huang, Ji Yun ^a   Tao, Rong Rong ^a   Liao, Mei Hua ^a   Lu, Ying Mei ^b   Ye, Wei Feng ^a,b   Wang, Rui ^a   Fukunaga, Kohji ^c   Lou, Yi Jia ^a   Han, Feng ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

DAPT; Degradation; Occludin; Permanent brain ischemia; Tight junction; Ubiquitination

Indexed keywords

BATIMASTAT; CALPASTATIN; EVANS BLUE; GAMMA SECRETASE INHIBITOR; OCCLUDIN; PROTEIN ZO1; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; IMMUNOPRECIPITATION; MALE; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PROTEIN DEGRADATION; RAT; UBIQUITINATION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD31; BLOOD-BRAIN BARRIER; DIPEPTIDES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; IMMUNOPRECIPITATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; OCCLUDIN; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS; TIME FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84871395062     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12032     Document Type: Article

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