Cytotoxicity of rat marrow stromal cells against malignant glioma cells

Child's Nervous System

Volumn 21, Issue 7, 2005, Pages 528-538

  Kang, Seok Gu ^a   Jeun, Sin Soo ^b   Lim, Jung Yeon ^c   Yoo, Do Sung ^d   Huh, Pil Woo ^d   Cho, Kyung Souk ^d   Kim, Dal Soo ^d   Shin, Hyung Jin ^a   Kim, Jong Hyun ^a   Kim, Moon Chan ^b   Kang, Joon Ki ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Uijeongbu St Mary's Hospital   (South Korea)

Author keywords

Cytokine; Cytotoxicity; Malignant glioma; Marrow stromal cells

Indexed keywords

CD16 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; PERFORIN;

ADOPTIVE TRANSFER; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL ASSAY; CELL DIFFERENTIATION; CELL ISOLATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA CELL; IMMUNE RESPONSE GENE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; ISOLATION PROCEDURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; STROMA CELL; TARGET CELL;

ANIMALS; ANTIGENS, CD; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BONE MARROW CELLS; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; DRUG COMBINATIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAS LIGAND PROTEIN; FLOW CYTOMETRY; GENE EXPRESSION; GLIOMA; GREEN FLUORESCENT PROTEINS; IN SITU NICK-END LABELING; INTERLEUKIN-4; MALE; MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROMAL CELLS; TRANSFECTION; TUMOR NECROSIS FACTORS;

EID: 23144452260     PISSN: 02567040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00381-005-1216-3     Document Type: Article

References (71)

1. Kalifa C, Valteau D, Pizer B, Vassal G, Grill J, Hartmann O (1999) High-dose chemotherapy in childhood brain tumours. Childs Nerv Syst 15:498-505 10.1007/s003810050538
2. Huncharek M, Wheeler L, McGarry R, Geschwind JF (1999) Chemotherapy response rates in recurrent/progressive pediatric glioma; results of a systematic review. Anticancer Res 19:3569-3574
3. Heideman RL, Kuttesch J Jr, Gajjar AJ, Walter AW, Jenkins JJ, Li Y, Sanford RA, Kun LE (1997) Supratentorial malignant gliomas in childhood: a single institution perspective. Cancer 80:497-504
4. Wisoff JH, Boyett JM, Berger MS, Brant C, Li H, Yates AJ, McGuire-Cullen P, Turski PA, Sutton LN, Allen JC, Packer RJ, Finlay JL (1998) Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: A report of the Children's Cancer Group trial no. CCG-945. J Neurosurg 89:5259 1:STN:280:DyaK1czgvFertQ%3D%3D
5. Johnson JH Jr, Phillips PC (1996) Malignant gliomas in children. Cancer Investig 14:609-621
6. Barker FG II, Prados MD, Chang SM, Gutin PH, Lamborn KR, Larson DA, Malec MK, McDermott MW, Sneed PK, Wara WM, Wilson CB (1996) Radiation response and survival time in patients with glioblastoma multiforme. J Neurosurg 84:442-448 8609556
7. Wolff JE, Gnekow AK, Kortmann RD, Pietsch T, Urban C, Graf N, Kuhl J (2002) Preradiation chemotherapy for pediatric patients with high-grade glioma. Cancer 94:264-271
8. Parney IF, Hao C, Petruk KC (2000) Glioma immunology and immunotherapy. Neurosurgery 46:778-791; discussion 791-772 10.1097/ 00006123-200004000-00002
9. Sampson JH, Archer GE, Ashley DM, Fuchs HE, Hale LP, Dranoff G, Bigner DD (1996) Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system. Proc Natl Acad Sci U S A 93:10399-10404 10.1073/pnas.93.19.10399
10. Soling A, Rainov NG (2001) Dendritic cell therapy of primary brain tumors. Mol Med 7:659-667 1:STN:280:DC%2BD3MnmslyjsQ%3D%3D
11. Hayes RL, Koslow M, Hiesiger EM, Hymes KB, Hochster HS, Moore EJ, Pierz DM, Chen DK, Budzilovich GN, Ransohoff J (1995) Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma. Cancer 76:840-852
12. Tsuboi K, Saijo K, Ishikawa E, Tsurushima H, Takano S, Morishita Y, Ohno T (2003) Effects of local injection of ex vivo expanded autologous tumor-specific T lymphocytes in cases with recurrent malignant gliomas. Clin Cancer Res 9:3294-3302 12960115
13. Tsurushima H, Liu SQ, Tuboi K, Matsumura A, Yoshii Y, Nose T, Saijo K, Ohno T (1999) Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes. Jpn J Cancer Res 90:536-545
14. Kang SG, Ryu CH, Jeun SS, Park CK, Shin HJ, Kim JH, Kim MC, Kang JK (2004) Lymphokine activated killer cells from umbilical cord blood show higher antitumor effect against anaplastic astrocytoma cell line (U87) and medulloblastoma cell line (TE671) than lymphokine activated killer cells from peripheral blood. Childs Nerv Syst 20:154-162 10.1007/ s00381-003-0866-2
15. Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT et al (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316:889-897 1:STN:280:BiiC2cvltFI%3D
16. Rosenberg SA, Lotze MT, Yang JC, Topalian SL, Chang AE, Schwartzentruber DJ, Aebersold P, Leitman S, Linehan WM, Seipp CA et al (1993) Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J Natl Cancer Inst 85:622-632 1:STN:280:ByyB38rhtlY%3D
17. Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T (2000) Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: A randomised trial. Lancet 356:802-807 10.1016/ S0140-6736(00)02654-4
18. Shi M, Zhang B, Tang ZR, Lei ZY, Wang HF, Feng YY, Fan ZP, Xu DP, Wang FS (2004) Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma. World J Gastroenterol 10:1146-1151 1:CAS:528:DC%2BD2cXksFGltrY%3D
19. Nagaraj S, Ziske C, Schmidt-Wolf IG (2004) Human cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer. Genet Vaccines Ther 2:12 10.1186/ 1479-0556-2-12
20. Schmidt-Wolf GD, Negrin RS, Schmidt-Wolf IG (1997) Activated T cells and cytokine-induced CD3+CD56+ killer cells. Ann Hematol 74:51-56 10.1007/ s002770050257
21. Linn YC, Hui KM (2003) Cytokine-induced killer cells: NK-like T cells with cytotolytic specificity against leukemia. Leuk Lymphoma 44:1457-1462 10.1080/1042819031000083082
22. Wang FS, Liu MX, Zhang B, Shi M, Lei ZY, Sun WB, Du QY, Chen JM (2002) Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World J Gastroenterol 8:464-468 1:CAS:528:DC%2BD38XlsF2ksr4%3D
23. Linn YC, Lau LC, Hui KM (2002) Generation of cytokine-induced killer cells from leukaemic samples with in vitro cytotoxicity against autologous and allogeneic leukaemic blasts. Br J Haematol 116:78-86 10.1046/j.1365-2141.2002.03247.x
24. Morse MA, Clay TM, Lyerly HK (2002) Current status of adoptive immunotherapy of malignancies. Expert Opin Biol Ther 2:237-247 10.1517/ 14712598.2.3.237
25. Carlens S, Gilljam M, Chambers BJ, Aschan J, Guven H, Ljunggren HG, Christensson B, Dilber MS (2001) A new method for in vitro expansion of cytotoxic human CD3-CD56+ natural killer cells. Hum Immunol 62:1092-1098 10.1016/S0198-8859(01)00313-5
26. AK Abbas AH Lichtman JS Pober 2000 Cellular and molecular immunology 4th edn. Saunders Philadelphia
27. Weissman IL (2000) Translating stem and progenitor cell biology to the clinic: Barriers and opportunities. Science 287:1442-1446 10.1126/ science.287.5457.1442
28. Weissman IL (2000) Stem cells: Units of development, units of regeneration, and units in evolution. Cell 100:157-168 1:CAS:528:DC%2BD3cXks1Cqsw%3D%3D
29. Fuchs E, Segre JA (2000) Stem cells: A new lease on life. Cell 100:143-155 10.1016/S0092-8674(00)81691-8
30. Friedenstein AJ (1976) Precursor cells of mechanocytes. Int Rev Cytol 47:327-359 1:STN:280:CSiD2M%2Fot1Q%3D
31. Kadiyala S, Young RG, Thiede MA, Bruder SP (1997) Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant 6:125-134 10.1016/ S0963-6897(96)00279-5
32. Barry FP (2003) Biology and clinical applications of mesenchymal stem cells. Birth Defects Res, C Embryo Today 69:250-256
33. Short B, Brouard N, Occhiodoro-Scott T, Ramakrishnan A, Simmons PJ (2003) Mesenchymal stem cells. Arch Med Res 34:565-571 10.1016/ j.arcmed.2003.09.007
34. Friedenstein AJ, Piatetzky S II, Petrakova KV (1966) Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 16:381-390 1:STN:280:CCiC38rhtVU%3D
35. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL (1998) Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 176:57-66 10.1002/ (SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7
36. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 98:10344-10349 10.1073/pnas.181177898
37. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701-705 10.1038/ 35070587
38. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S (1999) Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697-705 1:CAS:528:DyaK1MXhsF2is7s%3D
39. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP (1999) Bone marrow as a potential source of hepatic oval cells. Science 284:1168-1170 10.1126/science.284.5417.1168
40. Woodbury D, Reynolds K, Black IB (2002) Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 69:908-917 10.1002/jnr.10365
41. Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364-370 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C
42. Sanchez-Ramos JR (2002) Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res 69:880-893 10.1002/jnr.10337
43. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ (1998) Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci U S A 95:3908-3913 10.1073/pnas.95.7.3908
44. Brazelton TR, Rossi FM, Keshet GI, Blau HM (2000) From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290:1775-1779 10.1126/science.290.5497.1775
45. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ (2001) Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369-377 10.1016/ S0092-8674(01)00328-2
46. Bianco P, Cossu G (1999) Uno, nessuno e centomila: Searching for the identity of mesodermal progenitors. Exp Cell Res 251:257-263 10.1006/ excr.1999.4592
47. Anderson DJ, Gage FH, Weissman IL (2001) Can stem cells cross lineage boundaries? Nat Med 7:393-395 10.1038/86439
48. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229-1234 10.1038/81326
49. Kumagai N, Fukuda K, Ishimura Y, Nishida T (2000) Synergistic induction of eotaxin expression in human keratocytes by TNF-alpha and IL-4 or IL-13. Investig Ophthalmol Vis Sci 41:1448-1453 1:STN:280:DC%2BD3c3ls1Giuw%3D%3D
50. Hombauer H, Minguell JJ (2000) Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer 82:1290-1296 10.1054/bjoc.1999.1093
51. Maestroni GJ, Hertens E, Galli P (1999) Factor(s) from nonmacrophage bone marrow stromal cells inhibit Lewis lung carcinoma and B16 melanoma growth in mice. Cell Mol Life Sci 55:663-667 10.1007/s000180050322
52. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, Hamada H (2004) Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 11:1155-1164 10.1038/sj.gt.3302276
53. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R (2002) Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42-48 10.1016/ S0301-472X(01)00769-X
54. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843 10.1182/blood.V99.10.3838
55. Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, Dazzi F (2003) Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 101:3722-3729 10.1182/blood-2002-07-2104
56. Kim DW, Chung YJ, Kim TG, Kim YL, Oh IH (2004) Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 103:1941-1948 10.1182/blood-2003-05-1601
57. El-Badri NS, Maheshwari A, Sanberg PR (2004) Mesenchymal stem cells in autoimmune disease. Stem Cells Dev 13:463-472 10.1089/scd.2004.13.463
58. Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS (2002) The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 62:5657-5663
59. Ehtesham M, Kabos P, Gutierrez MA, Chung NH, Griffith TS, Black KL, Yu JS (2002) Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 62:7170-7174
60. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY (2000) Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci U S A 97:12846-12851 10.1073/pnas.97.23.12846
61. Stagg J, Lejeune L, Paquin A, Galipeau J (2004) Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy. Hum Gene Ther 15:597-608 10.1089/104303404323142042
62. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M (2002) Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 62:3603-3608
63. Simard AR, Rivest S (2004) Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J 18:998-1000 1:CAS:528:DC%2BD2cXkslWit7g%3D
64. Bhagwati SN (1989) Treatment of glioma with intratumoral instillation of autologous lymphocytes. Childs Nerv Syst 5:38-40 10.1007/BF00706746
65. Hayes RL, Arbit E, Odaimi M, Pannullo S, Scheff R, Kravchinskiy D, Zaroulis C (2001) Adoptive cellular immunotherapy for the treatment of malignant gliomas. Crit Rev Oncol/Hematol 39:31-42 10.1016/ S1040-8428(01)00122-6
66. Naganuma H, Sasaki A, Satoh E, Nagasaka M, Isoe S, Nakano S, Nukui H (1997) Long-term survival in a young patient with anaplastic glioma. Brain Tumor Pathol 14:71-74 1:STN:280:DyaK1c%2Fjtl2gug%3D%3D
67. Yamaguchi T, Suzuki Y, Katakura R, Ebina T, Yokoyama J, Fujimiya Y (1998) Interleukin-15 effectively potentiates the in vitro tumor-specific activity and proliferation of peripheral blood gammadeltaT cells isolated from glioblastoma patients. Cancer Immunol Immunother 47:97-103
68. Franzen R, Bouhy D, Schoenen J (2004) Nervous system injury: Focus on the inflammatory cytokine 'granulocyte-macrophage colony stimulating factor'. Neurosci Lett 361:76-78 10.1016/j.neulet.2003.12.018
69. Jean WC, Spellman SR, Wallenfriedman MA, Flores CT, Kurtz BP, Hall WA, Low WC (2004) Effects of combined granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2, and interleukin-12 based immunotherapy against intracranial glioma in the rat. J Neuro-oncol 66:39-49 10.1023/B:NEON.0000013477.94568.0f
70. Li Y, Chen J, Chen XG, Wang L, Gautam SC, Xu YX, Katakowski M, Zhang LJ, Lu M, Janakiraman N, Chopp M (2002) Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery. Neurology 59:514-523 1:STN:280:DC%2BD38vls1Sgug%3D%3D
71. Kimura S, Yoshino A, Katayama Y, Watanabe T, Fukushima T (2002) Growth control of C6 glioma in vivo by nerve growth factor. J Neuro-oncol 59:199-205 10.1023/A:1019919019497