Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 12, 2012, Pages

  Sendeski, Mauricio M ^a   Persson, Anja Bondke ^a   Liu, Zhi Zhao ^a   Busch, Jonas F ^a   Weikert, Steffen ^a   Persson, Pontus B ^a   Hippenstiel, Stefan ^a   Patzak, Andreas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Acute kidney injury; Endothelial dysfunction; Iodinated contrast media

Indexed keywords

ADRENOMEDULLIN; IODINATED CONTRAST MEDIUM; MYOSIN LIGHT CHAIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESCENDING VASA RECTA; ELECTRIC RESISTANCE; ELECTRON MICROSCOPY; ENDOTHELIAL DYSFUNCTION; HUMAN; HUMAN TISSUE; KIDNEY ARTERY; KIDNEY BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RENAL ARTERY; UMBILICAL VEIN ENDOTHELIAL CELL; VASOCONSTRICTION;

EID: 84871319599     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00471.2012     Document Type: Article

References (29)

1. Aliev G, Obrenovich ME, Seyidova D, Rzayev NM, Aliyev AS, Raina AK, Lamanna JC, Smith MA, Perry G. X-ray contrast media induce aortic endothelial damage, which can be prevented with prior heparin treatment. J Submicrosc Cytol Pathol 35: 253-266, 2003.
2. American College of Radiology (A.C.R.) Committee on Drugs, and Contrast Media. ACR Manual on Contrast Media (version 7). Reston, VA: ACR Committee on Drugs and Contrast Media, 2010.
3. Andres KH, von Dring M, Veh RW. Subnuclear organization of the rat habenular complexes. J Comp Neurol 407: 130-150, 1999.
4. Briguori C, Tavano D, Colombo A. Contrast agent-associated nephrotoxicity. Prog Cardiovasc Dis 45: 493-503, 2003.
5. Brunner E, Puri ML. Nonparametric methods in factorial designs. Stat Papers 42: 1-52, 2001.
6. Cao C, Edwards A, Sendeski M, Lee-Kwon W, Cui L, Cai CY, Patzak A, Pallone TL. Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction. Am J Physiol Renal Physiol 299: F1056-F1064, 2010.
7. Dangas G, Iakovou I, Nikolsky E, Aymong ED, Mintz GS, Kipshidze NN, Lansky AJ, Moussa I, Stone GW, Moses JW, Leon MB, Mehran R. Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables. Am J Cardiol 95: 13-19, 2005.
8. European Society of Urogenital Radiology (E.S.U.R.) Contrast Media Safety Committee. Guidelines of the ESUR on Contrast Media. Vienna, Austria: European Society of Urogenital Radiology (ESUR), 2010.
9. Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P. Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol 25: 6259-6266, 2005.
10. Fischer S, Gerriets T, Wessels C, Walberer M, Kostin S, Stolz E, Zheleva K, Hocke A, Hippenstiel S, Preissner KT. Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor. Blood 110: 2457-2465, 2007.
11. From AM, Bartholmai BJ, Williams AW, Cha SS, McDonald FS. Mortality associated with nephropathy after radiographic contrast exposure. Mayo Clin Proc 83: 1095100, 2008.
12. Gospos C, Koch HK, Mathias K, Seemann W, Tan KG, Papacharalampous X. Scanning electron microscopic (SEM) studies on the effect of x-ray contrast media on aortic endothelium in the rat. Invest Radiol 18: 382-386, 1983.
13. Heyman SN, Rosen S, Khamaisi M, Ideé JM, Rosenberger C. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol 45: 188-195, 2010.
14. Heyman SN, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation, and the pathogenesis of radiocontrast nephropathy. Clin J Am Soc Nephrol 3: 288-296, 2008.
15. Hillmeister P, Lehmann KE, Bondke A, Witt H, Duelsner A, Gruber C, Busch HJ, Jankowski J, Ruiz-Noppinger P, Hossmann KA, Buschmann IR. Induction of cerebral arteriogenesis leads to early-phase expression of protease inhibitors in growing collaterals of the brain. J Cereb Blood Flow Metab 28: 1811-1823, 2008.
16. Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 99: 2060-2069, 2002.
17. McCullough PA, Adam A, Becker CR, Davidson C, Lameire N, Stacul F, Tumlin J, Panel CINCW. Risk prediction of contrast-induced nephropathy. Am J Cardiol 98: 27K-36K, 2006.
18. N'Guessan PD, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, Slevogt H, Weichert W, Hocke AC, Schmeck B, Suttorp N, Hippenstiel S. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol 29: 380-386, 2009.
19. Pallone TL, Zhang Z, Rhinehart K. Physiology of the renal medullary microcirculation. Am J Physiol Renal Physiol 284: F253-F266, 2003.
20. Schmeck B, Beermann W, N'Guessan PD, Hocke AC, Opitz B, Eitel J, Dinh QT, Witzenrath M, Krll M, Suttorp N, Hippenstiel S. Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells. Circ Res 102: 888-895, 2008.
21. Seeliger E, Flemming B, Wronski T, Ladwig M, Arakelyan K, Godes M, Moeckel M, Persson PB. Viscosity of contrast media perturbs renal hemodynamics. J Am Soc Nephrol 18: 2912-2920, 2007.
22. Seeliger E, Sendeski M, Rihal CS, Persson PB. Contrast-induced kidney injury: mechanisms, risk factors, and prevention. Eur Heart J 33: 2007-2015, 2012.
23. Sendeski MM. Pathophysiology of renal tissue damage by iodinated contrast media. Clin Exp Pharmacol Physiol 38: 292-299, 2011.
24. Sendeski MM, Patzak A, Pallone TL, Cao C, Persson AE, Persson PB. Iodixanol, constriction of medullary descending vasa recta, and risk for contrast medium-induced nephropathy. Radiology 251: 697-704, 2009.
25. Sendeski MM, Patzak A, Persson PB. Constriction of the vasa recta, the vessels supplying the area at risk for acute kidney injury, by four different iodinated contrast media, evaluating ionic, nonionic, monomeric and dimeric agents. Invest Radiol 45: 453-457, 2010.
26. Temmesfeld-Wollbrck B, Hocke AC, Suttorp N, Hippenstiel S. Adrenomedullin and endothelial barrier function. Thromb Haemost 98: 944-951, 2007.
27. Tozer GM, Kanthou C, Baguley BC. Disrupting tumour blood vessels. Nat Rev Cancer 5: 423-435, 2005.
28. Wysolmerski RB, Lagunoff D. Regulation of permeabilized endothelial cell retraction by myosin phosphorylation. Am J Physiol Cell Physiol 261: C32-C40, 1991.
29. Yajima D, Motani H, Hayakawa M, Sato Y, Sato K, Iwase H. The relationship between cell membrane damage and lipid peroxidation under the condition of hypoxia-reoxygenation: analysis of the mechanism using antioxidants and electron transport inhibitors. Cell Biochem Funct 27: 338-343, 2009.