Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue

Journal of Membrane Biology

Volumn 245, Issue 12, 2012, Pages 841-857

  Omoto, Jaison J ^a   Maestas, Matthew J ^a   Rahnama Vaghef, Ali ^a   Choi, Ye E ^a   Salto Jr , Gerardo ^a   Sanchez, Rachel V ^a   Anderson, Cynthia M ^a   Eskandari, Sepehr ^a  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

Author keywords

Cysteine 74; GABA transporter; Neurotransmitter:Sodium symporter; SLC6; SLC6A1; Sulfhydryl modification

Indexed keywords

4 AMINOBUTYRIC ACID CARRIER; BUFFER; CYSTEINE; DITHIOTHREITOL; MALEIMIDE DERIVATIVE; MUTANT PROTEIN; N ETHYLMALEIMIDE; PROTEIN 4 AMINOBUTYRIC ACID TRANSPORTER 1; SODIUM CHLORIDE; SOLVENT; THIOL DERIVATIVE; THIOL REAGENT; TRACER; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL LABELING; CHEMICAL MODIFICATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXTRACELLULAR FLUID; INHIBITION KINETICS; ION DISPLACEMENT; NONHUMAN; OOCYTE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEADY STATE; XENOPUS LAEVIS;

ANIMALS; CYSTEINE; DITHIOTHREITOL; ETHYLMALEIMIDE; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; HUMANS; KINETICS; MESYLATES; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; RHODAMINES; SODIUM CHLORIDE; SULFHYDRYL REAGENTS; TRANSFECTION; VALPROIC ACID; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 84871313471     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-012-9492-9     Document Type: Article

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