The anticonvulsant valproate increases the turnover rate of γ-aminobutyric acid transporters

Journal of Biological Chemistry

Volumn 278, Issue 20, 2003, Pages 17716-17726

  Whitlow, Richard D ^a   Sacher, Ayelet ^b   Loo, Donald D F ^c   Nelson, Nathan ^b   Eskandari, Sepehr ^a  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL LABORATORIES; ELECTRIC CHARGE; ORGANIC ACIDS; PHYSIOLOGY;

ALLOSTERIC MECHANISM;

BIOCHEMISTRY;

CARRIER PROTEIN; CHLORIDE ION; PROTEIN GAT1; PROTEIN GAT3; PROTEIN GAT4; SODIUM ION; UNCLASSIFIED DRUG; VALPROIC ACID; 4 AMINOBUTYRIC ACID CARRIER; ANTICONVULSIVE AGENT; GABA PERMEASE; GABT4 PROTEIN, MOUSE; ION; MEMBRANE PROTEIN; ORGANIC ANION TRANSPORTER; SLC6A1 PROTEIN, HUMAN; SLC6A1 PROTEIN, MOUSE; SLC6A11 PROTEIN, HUMAN; SLC6A11 PROTEIN, MOUSE; SLC6A13 PROTEIN, MOUSE; SODIUM CHLORIDE;

4 AMINOBUTYRIC ACID UPTAKE; ALLOSTERISM; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROPHYSIOLOGY; GABAERGIC TRANSMISSION; HUMAN; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TURNOVER TIME; VOLTAGE CLAMP; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; GLIA; METABOLISM; MOUSE; NERVE CELL; TRANSPORT AT THE CELLULAR LEVEL; XENOPUS LAEVIS;

XENOPUS LAEVIS;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; IONS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, BIOLOGICAL; NEUROGLIA; NEURONS; ORGANIC ANION TRANSPORTERS; SODIUM CHLORIDE; VALPROIC ACID; XENOPUS LAEVIS;

EID: 0038719765     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207582200     Document Type: Article

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