Oleuropein prevents ethanol-induced gastric ulcers via elevation of antioxidant enzyme activities in rats

Journal of Physiology and Biochemistry

Volumn 68, Issue 4, 2012, Pages 583-592

  Alirezaei, Masoud ^a,b   Dezfoulian, Omid ^a   Neamati, Shima ^c   Rashidipour, Marzyeh ^c   Tanideh, Nader ^d   Kheradmand, Arash ^a  

^a LORESTAN UNIVERSITY   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant enzymes; Ethanol; Gastric ulcer; Oleuropein

Indexed keywords

ALCOHOL; CATALASE; GLUTATHIONE PEROXIDASE; LIPID; OLEUROPEIN; RANITIDINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NONHUMAN; PREMEDICATION; RAT; STOMACH PROTECTION; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; CATALASE; ETHANOL; GASTRIC MUCOSA; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PYRANS; RANITIDINE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; RATTUS;

EID: 84871272326     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0177-8     Document Type: Article

References (47)

1. Al-Azzawie HF, Alhamdani MSS (2006) Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci 78:1371-1377
2. Alirezaei M, Jelodar G, Niknam P, Ghayemi Z, Nazifi S (2011) Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum. J Physiol Biochem 67:605-612
3. Alirezaei M, Kheradmand A, Heydari R, Tanideh N, Neamati S, Rashidipour M (2012) Oleuropein protects against ethanolinduced oxidative stress and modulates sperm quality in the rat testis. Mediterr J Nutr Metab 1-7. DOI 10.1007/s12349- 011-0079-2
4. Andreadou I, Iliodromitis EK, Mikros E, Constantinou M, Agalias A, Magiatis P, Skaltsounis AL, Kamber E, Tsantili- Kakoulidou A, Kremastinos DT (2006) The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. J Nutr 136:2213-2219
5. Andreadou I, Sigala F, Iliodromitis EK, Papaefthimiou M, Sigalas C, Aligiannis N, Savvari P, Gorgoulis V, Papalabros E, Kremastinos D (2007) Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. J Mol Cell Cardiol 42:549-558
6. Andrikopoulos NK, Kaliora AC, Assimopoulou AN, Papageorgiou VP (2002) Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. J Med Food 5:1-7
7. Bandyopadhyay SK, Pakrashi SC, Pakrashi A (2000) The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. J Ethnopharmacol 70:171-176
8. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK (2003) A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 278:10993-11001
9. Chimi H, Cillard J, Cillard P, Rahmani M (1991) Peroxyl and hydroxyl radical scavenging activity of some natural phenolic antioxidants. J Am Oil Chem Soc 68:307-312
10. Claiborn A (1986) CRC handbook of methods for oxygen radical research. CRC press, Boca Raton
11. Das D, Banerjee RK (1993) Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem 125:115- 125
12. Das D, Bandyopadhyay D, Bhattacharjee M, Banerjee RK (1997) Hydroxyl radical is themajor causative factor in stressinduced gastric ulceration. Free Rad Biol Med 23:8-18
13. De Barros MP, Sousa JPB, Bastos JK, De Andrade SF (2007) Effect of Brazilian green propolis on experimental gastric ulcers in rats. J Ethnopharmacol 110:567-571
14. De Souza GEP, Cardoso RA, Melo MCC, Fabricio ASC, Silva VMS, Lora M, De Brum-Fernandes AJ, Rae GA, Ferreira SH, Zampronio AR (2002) A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. Inflam Res 51:24-32
15. Dekanski D, Ristic S, Mitrovic DM (2009) Antioxidant effect of dry olive (Olea europaea L.) leaf extract on ethanol-induced gastric lesions in rats. Mediterr J Nutr Metab 2:205-211
16. Dekanski D, Janicijevic-Hudomal S, Ristic S, Radonjic NV, Petronijevic ND, Piperski V, Mitrovic DM (2009) Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract. Gen Physiol Biophys 28:135-142
17. Del Boccio P, Di Deo A, De Curtis A, Celli N, Iacoviello L, Rotilio D (2003) Liquid chromatography-tandem mass spectrometry analysis of oleuropein and its metabolite hydroxytyrosol in rat plasma and urine after oral administration. J Chromatogr B 785:47-56
18. Elliott SN, Wallace JL (1998) Neutrophil-mediated gastrointestinal injury. Can J Gastroenterol 12:559-568
19. Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I (1992) Hypoglycemic activity of olive leaf. Planta Med 58:513-515
20. Hetil O (1993) Mechanism of free radicals in gastrointestinal and liver diseases. J Clin Biol 134:675-683
21. Isenberg JI, McQuaid KR, Laine L, Walsh JH (1995) Acidpeptic disorders. Textbook Gastroenterol 1:1.347-1.430
22. Itoh M, Guth PH (1985) Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 88:1165-1167
23. Kheradmand A, Alirezaei M, Birjandi M (2010) Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary. Regul Pept 162:84-89
24. Kheradmand A, Dezfoulian O, Tarrahi MJ (2011) Ghrelin attenuates heat-induced degenerative effects in the rat testis. Regul Pept 167:97-104
25. Kheradmand A, Alirezaei M, Asadian P, Rafiei Alavi E, Joorabi S (2009) Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia 41:335-340
26. Lankin VZ, Tikhaze AK, Konovalova GG, Kozachenko AI (1999) Concentration inversion of the antioxidant and prooxidant effects of beta-carotene in tissues in vivo. Biull Eksp Biol Med 128:314-316
27. Lee JH, Lee DU, Jeong CS (2009) Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. Food Chem Toxicol 47:1127-1131
28. Leirisalo-Repo M, Paimela L, Koskimies S, Repo H (1993) Functions of polymorphonuclear leukocytes in early rheumatoid arthritis. Inflammation 17:427-442
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
30. Lpoez-Miranda J, Perez-Jimenez F, Ros E, De Caterina R, Badimon L, Covas MI, Escrich E, Ordovas JM, Soriguer F, Abia R (2010) Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovas Dis 20:284-294
31. Manna C, Migliardi V, Golino P, Scognamiglio A, Galletti P, Chiariello M, Zappia V (2004) Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. J Nutr Biochem 15:461-466
32. Manna C, D'Angelo S, Migliardi V, Loffredi E, Mazzoni O, Morrica P, Galletti P, Zappia V (2002) Protective effect of the phenolic fraction from virgin olive oils against oxidative stress in human cells. J Agric Food Chem 50:6521-6526
33. Miura T, Muraoka S, Fujimoto Y (2002) Lipid peroxidation induced by indomethacin with horseradish peroxidase and hydrogen peroxide: involvement of indomethacin radicals. Biochem Pharmacol 63:2069-2074
34. Neamati S, Alirezaei M, Kheradmand A (2011) Ghrelin acts as an antioxidant agent in the rat kidney. Int J Pept Res Therap 17:239-245
35. Odabasoglu F, Cakir A, Suleyman H, Aslan A, Bayir Y, Halici M, Kazaz C (2006) Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol 103:59-65
36. Park SW, Lee SM (2008) Antioxidant and prooxidant properties of ascorbic acid on hepatic dysfunction induced by cold ischemia/reperfusion. Eur J Pharmacol 580:401-406
37. Peltola V, Huhtaniemi I, Ahotupa M (1992) Antioxidant enzyme activity in the maturing rat testis. J Androl 13:450-455
38. Santra A, Chowdhury A, Chaudhuri S, Gupta JD, Banerjee PK, Guha Mazumder DN (2000) Oxidative stress in gastric mucosa in Helicobacter pylori infection. Ind J Gastroenterol 19:21-23
39. Sedlak J, Lindsay RH (1968) Estimation of total, proteinbound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25:192-205
40. Sehirli O, Sener E, Sener G, Cetinel S, Erzik C, Yegen BC (2008) Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines. Peptides 29:1231- 1240
41. Smith SM, Kvietys PR (1988) Gastric ulcers: role of oxygen radicals. Crit Care Med 16:892-898
42. Subbarao KV, Richardson JS, Ang LC (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 55:342-345
43. Tuck KL, Freeman MP, Hayball PJ, Stretch GL, Stupans I (2001) The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats. J Nutr 131:1993- 1996
44. Turner TT, Lysiak JJ (2008) Oxidative stress: a common factor in testicular dysfunction. J Androl 29:488-498
45. Visioli F, Bellomo G, Galli C (1998) Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 247:60-64
46. Wallace JL (2001) Mechanisms of protection and healing: current knowledge and future research. Am J Med 110:S19- S23
47. Zarzuelo A, Duarte J, Jimenez J, Gonzlez M, Utrilla MP (1991) Vasodilator effect of olive leaf. Planta Med 57:417- 419