Lipid peroxidation induced by indomethacin with horseradish peroxidase and hydrogen peroxide: Involvement of indomethacin radicals

Biochemical Pharmacology

Volumn 63, Issue 11, 2002, Pages 2069-2074

  Miura, Toshiaki ^a   Muraoka, Sanae ^a   Fujimoto, Yukio ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Horseradish peroxidase; Indomethacin; Lipid peroxidation; Nonsteroidal anti inflammatory drug

Indexed keywords

CATALASE; DEFEROXAMINE; FERRIC ION; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; INDOMETACIN; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; INCUBATION TIME; INTESTINE; LIPID PEROXIDATION; LIVER MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; STOMACH; STOMACH MUCOSA LESION; TISSUE INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG INTERACTIONS; FREE RADICAL SCAVENGERS; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; INDOMETHACIN; IRON; IRON CHELATING AGENTS; LIPID PEROXIDATION; MICROSOMES, LIVER; RATS; RATS, WISTAR;

EID: 0036609498     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00995-4     Document Type: Article

References (35)

1. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
2. Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents
3. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs
4. Nonsteroidal anti-inflammatory drug gastropathy: Causes and treatment
5. Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes
6. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs
7. Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats
8. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury
9. Lipid peroxidation in gastric mucosal lesions induced by indomethacin in rat
10. 2 biosynthesis
11. Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment, possible location of a prosthetic heme binding site
12. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities
13. Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system
14. Oxidation of the substituted catechols dihydroxyphenylalanine methyl ester and trihydroxyphenylalanine by lactoperoxidase and its compounds
15. Evidence for one-electron oxidation of benzylpenicillin G by lactoperoxidase compounds I and II
16. 1,3-Butadiene oxidation by human myeloperoxidase. Role of chloride ion in catalysis of divergent pathways
17. Nonsteroidal anti-inflammatory drugs interact with horseradish peroxidase in an in vitro assay system for hydrogen peroxide scavenging
18. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process
19. Oxidative inactivation of gastric peroxidase by site-specific generation of hydroxyl radical and its role in stress-induced gastric ulceration
20. Lactoperoxidase-catalysed oxidation of indomethacin, a nonsteroidal anti-inflammatory drug, through the formation of a free radical
21. Inhibition of lipid peroxidation by estradiol and 2-hydroxyestradiol
22. Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fraction
23. Microsomal lipid peroxidation
24. Inhibition of microsomal lipid peroxidation by α-tocopherol and α-tocopherol acetate
25. Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)
26. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats
27. The role of iron in oxygen radical mediated lipid peroxidation
28. Formation of thiobarbituric acid-reactive substance from deoxyribose in the presence of iron salts: The role of superoxide and hydroxyl radicals
29. 2-reactive species in oxygen toxicity in biology
30. The reduction of ferryl myoglobin by ergothioneine: A novel function for ergothioneine
31. 2+) complex, a possible mechanism of nigrostriatal cell damage
32. Free radical-lipid interactions and their pathological consequences
33. Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase
34. Enhanced lipid peroxidation of erythrocyte membranes and phosphatidylcholine liposomes induced by a xanthine oxidase system in the presence of catalase
35. Xanthine oxidase- and iron-dependent lipid peroxidation