An α7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 1, 2010, Pages 173-180

  Marrero, Mario B ^a   Lucas, Rudolf ^a   Salet, Christina ^a   Hauser, Terry A ^b   Mazurov, Anatoly ^b   Lippiello, Patrick M ^b   Bencherif, Merouane ^b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b TARGACEPT INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYL N [ 2 (PYRIDIN 3 YLMETHYL) 1 AZA BICYCLO[ 2.2.2 ]OCT 3 YL]THIOPHENE 2 CARBOXAMIDE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR SELECTIVE AGONIST; BUNGAROTOXIN RECEPTOR; CYTOKINE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; JANUS KINASE 2; JANUS KINASE INHIBITOR; LEPTIN; LEPTIN RECEPTOR; LIPID; METHYLLYCACONITINE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NICOTINIC AGENT; STAT3 PROTEIN; TC 7020; THIOPHENE DERIVATIVE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALPHA-BUNGAROTOXIN RECEPTOR; LIGAND; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENERGY METABOLISM; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LINKAGE ANALYSIS; LIPID METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ELECTROPHYSIOLOGY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETICS; METABOLISM; MOLECULAR CLONING; MOUSE MUTANT; OOCYTE; PATCH CLAMP; PHYSIOLOGY; RAT; XENOPUS LAEVIS;

ANIMALS; BINDING, COMPETITIVE; BLOOD GLUCOSE; CELL LINE; CLONING, MOLECULAR; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ELECTROPHYSIOLOGICAL PHENOMENA; ENERGY METABOLISM; FEMALE; HUMANS; LIGANDS; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; NICOTINIC AGONISTS; OBESITY; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, LEPTIN; RECEPTORS, NICOTINIC; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT GAIN; XENOPUS LAEVIS;

EID: 73949111377     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.154633     Document Type: Article

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