Antishock effect of anisodamine involves a novel pathway for activating α7 nicotinic acetylcholine receptor

Critical Care Medicine

Volumn 37, Issue 2, 2009, Pages 634-641

  Liu, Chong ^a   Shen, Fu Ming ^a   Le, Ying Ying ^b   Kong, Yan ^b   Liu, Xia ^a   Cai, Guo Jun ^a   Chen, Alex F ^c   Su, Ding Feng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Anisodamine; Cholinergic anti inflammatory pathway; Septic shock; 7 nicotinic acetylcholine receptor

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; ANISODAMINE; ANISODAMINE HYDROCHLORIDE; BUNGAROTOXIN RECEPTOR; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; METHYLLYCACONITINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTISHOCK EFFECT; ARTICLE; ATTENUATION; BIOLOGICAL MONITORING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPOTENSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO CULTURE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SUPERNATANT; VAGOTOMY;

ACONITINE; ANIMALS; BASE SEQUENCE; CELL LINE; CHINA; DNA PRIMERS; INTERLEUKIN-1BETA; MACROPHAGES, PERITONEAL; MICE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SHOCK, SEPTIC; SOLANACEOUS ALKALOIDS; TUMOR NECROSIS FACTOR-ALPHA; VAGOTOMY;

EID: 67650398292     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819598f5     Document Type: Article

References (30)

1. Matot I, Sprung CL: Definition of sepsis. Intensive Care Med 2001; 27:3-9
2. Su CF, Yang FL, Chen HI: Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Clin Exp Pharmacol Physiol 2007; 34: 339-346
3. Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 2003; 9:517-524
4. Kao SJ, Su CF, Liu DD: Endotoxin-induced acute lung injury and organ dysfunction are attenuated by pentobarbital anaesthesia. Clin Exp Pharmacol Physiol 2007; 34:480-487
5. Borovikova LV, Ivanova S, Zhang M, et al: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405:458-462
6. Wang H, Yu M, Ochani M, et al: Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003; 421:384-388
7. Bernik TR, Friedman SG, Ochani M, et al: Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 2002; 195:781-788
8. Guarini S, Altavilla D, Cainazzo MM, et al: Efferent vagal fiber stimulation blunts nuclear factor-kappa B activation and protects against hypovolemic hemorrhagic shock. Circulation 2003; 107:1189-1194
9. Li M, Zheng C, Sato T, et al: Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 2004; 109:120-124
10. Pavlov VA, Ochani M, Yang LH, et al: Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med 2007; 35:1139-1144
11. van Westerloo DJ, Giebelen IA, Florquin S, et al: The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 2006; 130: 1822-1830
12. Martin LF, Kem WR, Freedman R, et al: Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl) 2004; 174:54-64
13. Saeed RW, Varma S, Peng-Nemeroff T, et al: Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 2005; 201: 1113-1123
14. Wang ST, Kuo NL: Experience in emergency treatment of shock due to infection. Chin Med J 1978; 6:497-500
15. Xiu RJ: Studies on microcirculation in the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. Microvasc Res 1980; 20:371-373
16. Poupko JM, Baskin SI, Moore E: The pharmacological properties of anisodamine. J Appl Toxicol 2007; 27:116-121
17. Shen FM, Wang J, Ni CR, et al: Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT (2A) receptors. Clin Exp Pharmacol Physiol 2007; 34:702-707
18. van Westerloo DJ, Giebelen IA, Florquin S, et al: The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 2005; 191: 2138-2148
19. Kane GC, Lam CF, O'Cochlain F, et al: Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia. FASEB J 2006; 20: 2271-2280
20. Chen HH: Large dose atropine alkaloids in the treatment of shock. Resuscitation 1983; 10:149-151
21. Hinshaw LB, Archer LT, Black MR, et al: Prevention and reversal of myocardial failure in endotoxin shock. Surg Gynecol Obstet 1973; 36:1-11
22. Li QB, Pan R, Wang GF, et al: Anisodamine as an effective drug to treat snakebites. J Nat Toxins 1999; 8:327-330
23. Villiger Y, Szanto I, Jaconi S, et al: Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes. J Neuroimmunol 2002; 126:86-98
24. De Simone R, Ajmone-Cat MA, Carnevale D, et al: Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prosta-glandin E2 in rat microglial cultures. J Neuroinflammation 2005; 2:4
25. Su JY, Wu L, Tang C: Experimental study in rabbits of the antishock effect of anisodamine (654-2), and its mechanism of action. Resuscitation 1983; 10:173-184
26. Feldmann M: Development of anti-TNF therapy for rheumatoid arthritis. Nature Rev Immunol 2002; 2:364-371
27. Van Assche G, Rutgeerts P: Anti-TNF agents in Crohn's disease. Expert Opin Investig Drugs 2000; 9:103-111
28. Abraham E, Anzueto A, Gutierrez G, et al: Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998; 351:929-933
29. de Jonge WJ, Ulloa L: The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol 2007; 151:915-929
30. Ulloa L: The vagus nerve and the nicotinic anti-inflammatory pathway. Nat Rev Drug Discov 2005; 4:673-684