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Volumn 19, Issue 1, 2013, Pages 18-23

Asthma phenotypes and endotypes

Author keywords

asthma; endotypes; personalized medicine; phenotypes

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR BETA; GOLIMUMAB; LEBRIKIZUMAB; MEPOLIZUMAB;

EID: 84871250908     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e32835b10ec     Document Type: Review
Times cited : (42)

References (80)
  • 1
    • 60549112237 scopus 로고    scopus 로고
    • A population-based clinical study of allergic and nonallergic asthma
    • Knudsen TB, Thomsen SF, Nolte H, Backer V. A population-based clinical study of allergic and nonallergic asthma. J Asthma 2009; 46:91-94.
    • (2009) J Asthma , vol.46 , pp. 91-94
    • Knudsen, T.B.1    Thomsen, S.F.2    Nolte, H.3    Backer, V.4
  • 2
    • 0033060552 scopus 로고    scopus 로고
    • How much asthma is really attributable to atopy?
    • Pearce N, Pekkanen J, Beasley R. How much asthma is really attributable to atopy? Thorax 1999; 54:268-272.
    • (1999) Thorax , vol.54 , pp. 268-272
    • Pearce, N.1    Pekkanen, J.2    Beasley, R.3
  • 3
    • 0033022464 scopus 로고    scopus 로고
    • The natural history of asthma in adults: The problem of irreversibility
    • Reed CE. The natural history of asthma in adults: the problem of irreversibility. J Allergy Clin Immunol 1999; 103:539-547.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 539-547
    • Reed, C.E.1
  • 4
    • 84860003141 scopus 로고    scopus 로고
    • Nonatopic males with adult onset asthma are at risk of persistent airflow limitation
    • Amelink M, de Nijs SB, Berger M, et al. Nonatopic males with adult onset asthma are at risk of persistent airflow limitation. Clin Exp Allergy 2012; 42:769-774.
    • (2012) Clin Exp Allergy , vol.42 , pp. 769-774
    • Amelink, M.1    De Nijs, S.B.2    Berger, M.3
  • 5
    • 10544256182 scopus 로고    scopus 로고
    • IL-4 and IL-5 MRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: Evidence against "intrinsic" asthma being a distinct immunopathologic entity
    • Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154:1497-1504.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1497-1504
    • Humbert, M.1    Durham, S.R.2    Ying, S.3
  • 6
    • 0029889058 scopus 로고    scopus 로고
    • High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma
    • Humbert M, Grant JA, Taborda-Barata L, et al. High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Respir Crit Care Med 1996; 153:1931-1937.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1931-1937
    • Humbert, M.1    Grant, J.A.2    Taborda-Barata, L.3
  • 7
    • 0026666718 scopus 로고
    • Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
    • Walker C, Bode E, Boer L, et al. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992; 146:109-115.
    • (1992) Am Rev Respir Dis , vol.146 , pp. 109-115
    • Walker, C.1    Bode, E.2    Boer, L.3
  • 8
    • 0036855114 scopus 로고    scopus 로고
    • Expert panel report. Guidelines for the diagnosis and management of asthma update on selected topics-2002
    • National Asthma Education and Prevention Program
    • National Asthma Education and Prevention Program. Expert Panel Report. Guidelines for the diagnosis and management of asthma update on selected topics-2002. J Allergy Clin Immunol 2002; 110:S141-S219.
    • (2002) J Allergy Clin Immunol , vol.110
  • 9
    • 39049170984 scopus 로고    scopus 로고
    • Global strategy for asthma management and prevention: GINA executive summary
    • Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31:143-178.
    • (2008) Eur Respir J , vol.31 , pp. 143-178
    • Bateman, E.D.1    Hurd, S.S.2    Barnes, P.J.3
  • 10
    • 0034526865 scopus 로고    scopus 로고
    • Current understanding, recommendations, and unanswered questions. American Thoracic Society
    • Proceedings of the ATS workshop on refractory asthma
    • Proceedings of the ATS workshop on refractory asthma. Current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000; 162:2341-2351.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
  • 11
    • 0033025989 scopus 로고    scopus 로고
    • Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society
    • Chung KF, Godard P, Adelroth E, et al. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J 1999; 13:1198-1208.
    • (1999) Eur Respir J , vol.13 , pp. 1198-1208
    • Chung, K.F.1    Godard, P.2    Adelroth, E.3
  • 12
    • 78049457548 scopus 로고    scopus 로고
    • Uniform definition of asthma severity, control, and exacerbations: Document presented for the
    • World Health Organization Consultation on Severe Asthma
    • Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-938.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 926-938
    • Bousquet, J.1    Mantzouranis, E.2    Cruz, A.A.3
  • 13
    • 80052829963 scopus 로고    scopus 로고
    • Diagnosis and definition of severe refractory asthma: An international consensus statement from the Innovative Medicine Initiative (IMI)
    • Bel EH, Sousa A, Fleming L, et al. Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI). Thorax 2011; 66:910-917.
    • (2011) Thorax , vol.66 , pp. 910-917
    • Bel, E.H.1    Sousa, A.2    Fleming, L.3
  • 14
    • 0028170510 scopus 로고
    • TH2 and 'TH2-like' cells in allergy and asthma: Pharmacological perspectives
    • Anderson GP, Coyle AJ. TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sci 1994; 15:324-332.
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 324-332
    • Anderson, G.P.1    Coyle, A.J.2
  • 15
    • 34147130329 scopus 로고    scopus 로고
    • Master switches of T-cell activation and differentiation
    • Beier KC, Kallinich T, Hamelmann E. Master switches of T-cell activation and differentiation. Eur Respir J 2007; 29:804-812.
    • (2007) Eur Respir J , vol.29 , pp. 804-812
    • Beier, K.C.1    Kallinich, T.2    Hamelmann, E.3
  • 16
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008; 118:3546-3556.
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 17
    • 79958202765 scopus 로고    scopus 로고
    • Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype
    • Risse PA, Jo T, Suarez F, et al. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Am J Physiol Lung Cell Mol Physiol 2011; 300:L958-L966.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300
    • Risse, P.A.1    Jo, T.2    Suarez, F.3
  • 20
    • 40049107712 scopus 로고    scopus 로고
    • Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
    • Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008; 121:560-570.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 560-570
    • Broide, D.H.1
  • 21
    • 33750592575 scopus 로고    scopus 로고
    • Epithelial damage and angiogenesis in the airways of children with asthma
    • Barbato A, Turato G, Baraldo S, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006; 174:975-981.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 975-981
    • Barbato, A.1    Turato, G.2    Baraldo, S.3
  • 22
    • 36049007283 scopus 로고    scopus 로고
    • Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
    • Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007; 176:858-864.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 858-864
    • Saglani, S.1    Payne, D.N.2    Zhu, J.3
  • 24
    • 77956192697 scopus 로고    scopus 로고
    • Airway remodelling in asthma: From benchside to clinical practice
    • Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J 2010; 17:e85-e93.
    • (2010) Can Respir J , vol.17
    • Bergeron, C.1    Tulic, M.K.2    Hamid, Q.3
  • 26
    • 57349134464 scopus 로고    scopus 로고
    • Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    • Aysola RS, Hoffman EA, Gierada D, et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 2008; 134:1183-1191.
    • (2008) Chest , vol.134 , pp. 1183-1191
    • Aysola, R.S.1    Hoffman, E.A.2    Gierada, D.3
  • 27
    • 0037952701 scopus 로고    scopus 로고
    • Airway structural alterations selectively associated with severe asthma
    • Benayoun L, Druilhe A, Dombret MC, et al. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167:1360-1368.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1360-1368
    • Benayoun, L.1    Druilhe, A.2    Dombret, M.C.3
  • 28
    • 34249779227 scopus 로고    scopus 로고
    • Specificity of basement membrane thickening in severe asthma
    • Bourdin A, Neveu D, Vachier I, et al. Specificity of basement membrane thickening in severe asthma. J Allergy Clin Immunol 2007; 119:1367-1374.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1367-1374
    • Bourdin, A.1    Neveu, D.2    Vachier, I.3
  • 29
    • 3543146737 scopus 로고    scopus 로고
    • Parameters associated with persistent airflow obstruction in chronic severe asthma
    • Bumbacea D, Campbell D, Nguyen L, et al. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J 2004; 24:122-128.
    • (2004) Eur Respir J , vol.24 , pp. 122-128
    • Bumbacea, D.1    Campbell, D.2    Nguyen, L.3
  • 30
    • 24644511857 scopus 로고    scopus 로고
    • Differences in airway remodeling between subjects with severe and moderate asthma
    • Pepe C, Foley S, Shannon J, et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 2005; 116:544-549.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 544-549
    • Pepe, C.1    Foley, S.2    Shannon, J.3
  • 31
    • 0033821409 scopus 로고    scopus 로고
    • Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    • Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000; 20:6891-6903.
    • (2000) Mol Cell Biol , vol.20 , pp. 6891-6903
    • Ito, K.1    Barnes, P.J.2    Adcock, I.M.3
  • 32
    • 77952951084 scopus 로고    scopus 로고
    • Mechanisms and resistance in glucocorticoid control of inflammation
    • Barnes PJ. Mechanisms and resistance in glucocorticoid control of inflammation. J Steroid Biochem Mol Biol 2010; 120:76-85.
    • (2010) J Steroid Biochem Mol Biol , vol.120 , pp. 76-85
    • Barnes, P.J.1
  • 33
    • 33644777427 scopus 로고    scopus 로고
    • Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma
    • Bergeron C, Fukakusa M, Olivenstein R, et al. Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma. J Allergy Clin Immunol 2006; 117:703-705.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 703-705
    • Bergeron, C.1    Fukakusa, M.2    Olivenstein, R.3
  • 34
    • 0034502208 scopus 로고    scopus 로고
    • Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma
    • Christodoulopoulos P, Leung DY, Elliott MW, et al. Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma. J Allergy Clin Immunol 2000; 106:479-484.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 479-484
    • Christodoulopoulos, P.1    Leung, D.Y.2    Elliott, M.W.3
  • 35
    • 0032914288 scopus 로고    scopus 로고
    • Etal. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma
    • Hamid QA, Wenzel SE, Hauk PJ, etal. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 1999; 159:1600-1604.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1600-1604
    • Hamid, Q.A.1    Wenzel, S.E.2    Hauk, P.J.3
  • 36
    • 0036231010 scopus 로고    scopus 로고
    • P38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
    • Irusen E, Matthews JG, Takahashi A, et al. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109:649-657.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 649-657
    • Irusen, E.1    Matthews, J.G.2    Takahashi, A.3
  • 37
    • 0027242280 scopus 로고
    • Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids
    • Kam JC, Szefler SJ, Surs W, et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993; 151:3460-3466.
    • (1993) J Immunol , vol.151 , pp. 3460-3466
    • Kam, J.C.1    Szefler, S.J.2    Surs, W.3
  • 38
    • 0030702823 scopus 로고    scopus 로고
    • Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
    • Leung DY, Hamid Q, Vottero A, et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 1997; 186:1567-1574.
    • (1997) J Exp Med , vol.186 , pp. 1567-1574
    • Leung, D.Y.1    Hamid, Q.2    Vottero, A.3
  • 39
    • 2342567291 scopus 로고    scopus 로고
    • Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in gluco-corticoid-resistant patients
    • Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in gluco-corticoid-resistant patients. J Allergy Clin Immunol 2004; 113:1100-1108.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1100-1108
    • Matthews, J.G.1    Ito, K.2    Barnes, P.J.3    Adcock, I.M.4
  • 40
    • 0028079557 scopus 로고
    • Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy
    • Sher ER, Leung DY, Surs W, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93:33-39.
    • (1994) J Clin Invest , vol.93 , pp. 33-39
    • Sher, E.R.1    Leung, D.Y.2    Surs, W.3
  • 41
    • 0022393794 scopus 로고
    • Primary structure and expression of a functional human glucocorticoid receptor cDNA
    • Hollenberg SM, Weinberger C, Ong ES, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985; 318:635-641.
    • (1985) Nature , vol.318 , pp. 635-641
    • Hollenberg, S.M.1    Weinberger, C.2    Ong, E.S.3
  • 42
    • 0029056558 scopus 로고
    • Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger CM, Bamberger AM, de CM, Chrousos GP. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95:2435-2441.
    • (1995) J Clin Invest , vol.95 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    De Cm Chrousos, G.P.3
  • 43
    • 0029993518 scopus 로고    scopus 로고
    • The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function
    • Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem 1996; 271:9550-9559.
    • (1996) J Biol Chem , vol.271 , pp. 9550-9559
    • Oakley, R.H.1    Sar, M.2    Cidlowski, J.A.3
  • 44
    • 0033600936 scopus 로고    scopus 로고
    • The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action
    • Oakley RH, Jewell CM, Yudt MR, et al. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem 1999; 274:27857-27866.
    • (1999) J Biol Chem , vol.274 , pp. 27857-27866
    • Oakley, R.H.1    Jewell, C.M.2    Yudt, M.R.3
  • 45
    • 31044434618 scopus 로고    scopus 로고
    • CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform
    • Tliba O, Cidlowski JA, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol Pharmacol 2006; 69:588-596.
    • (2006) Mol Pharmacol , vol.69 , pp. 588-596
    • Tliba, O.1    Cidlowski, J.A.2    Amrani, Y.3
  • 46
    • 77955350723 scopus 로고    scopus 로고
    • Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by t-helper type 17 cytokines
    • Vazquez-Tello A, Semlali A, Chakir J, et al. Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines. Clin Exp Allergy 2010; 40:1312-1322.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1312-1322
    • Vazquez-Tello, A.1    Semlali, A.2    Chakir, J.3
  • 47
    • 33745746529 scopus 로고    scopus 로고
    • Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
    • Hew M, Bhavsar P, Torrego A, et al. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med 2006; 174:134-141.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 134-141
    • Hew, M.1    Bhavsar, P.2    Torrego, A.3
  • 48
    • 0842308109 scopus 로고    scopus 로고
    • Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: Role of tyrosine nitration
    • Ito K, Hanazawa T, Tomita K, et al. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004; 315:240-245.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 240-245
    • Ito, K.1    Hanazawa, T.2    Tomita, K.3
  • 49
    • 79952587807 scopus 로고    scopus 로고
    • Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3PDE4 inhibition in human alveolar macrophages
    • Milara J, Navarro A, Almudever P, et al. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin Exp Allergy 2011; 41:535-546.
    • (2011) Clin Exp Allergy , vol.41 , pp. 535-546
    • Milara, J.1    Navarro, A.2    Almudever, P.3
  • 50
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: Insights from clinical studies
    • Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009; 6:256-259.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 256-259
    • Fahy, J.V.1
  • 51
    • 0030953977 scopus 로고    scopus 로고
    • Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins
    • Hogan SP, Mould A, Kikutani H, et al. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J Clin Invest 1997; 99:1329-1339.
    • (1997) J Clin Invest , vol.99 , pp. 1329-1339
    • Hogan, S.P.1    Mould, A.2    Kikutani, H.3
  • 53
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 54
    • 42249088428 scopus 로고    scopus 로고
    • Eosinophils: Biological properties and role in health and disease
    • Hogan SP, Rosenberg HF, Moqbel R, et al. Eosinophils: biological properties and role in health and disease. Clin Exp Allergy 2008; 38:709-750.
    • (2008) Clin Exp Allergy , vol.38 , pp. 709-750
    • Hogan, S.P.1    Rosenberg, H.F.2    Moqbel, R.3
  • 55
    • 31944440761 scopus 로고    scopus 로고
    • Corticosteroid effects on cell signalling
    • Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006; 27:413-426.
    • (2006) Eur Respir J , vol.27 , pp. 413-426
    • Barnes, P.J.1
  • 56
    • 0032826640 scopus 로고    scopus 로고
    • Asymptomatic airway hyperresponsiveness: Relationships with airway inflammation and remodelling
    • Laprise C, Laviolette M, Boutet M, Boulet LP. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J 1999; 14:63-73.
    • (1999) Eur Respir J , vol.14 , pp. 63-73
    • Laprise, C.1    Laviolette, M.2    Boutet, M.3    Boulet, L.P.4
  • 57
    • 84859180524 scopus 로고    scopus 로고
    • Genetic basis for personalized medicine in asthma
    • Portelli M, Sayers I. Genetic basis for personalized medicine in asthma. Expert Rev Respir Med 2012; 6:223-236.
    • (2012) Expert Rev Respir Med , vol.6 , pp. 223-236
    • Portelli, M.1    Sayers, I.2
  • 58
    • 67650752133 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    • Hackett TL, Warner SM, Stefanowicz D, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009; 180:122-133.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 122-133
    • Hackett, T.L.1    Warner, S.M.2    Stefanowicz, D.3
  • 59
    • 15944362722 scopus 로고    scopus 로고
    • Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    • Balzar S, Chu HW, Strand M, Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005; 171:431-439.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 431-439
    • Balzar, S.1    Chu, H.W.2    Strand, M.3    Wenzel, S.4
  • 60
    • 79551511756 scopus 로고    scopus 로고
    • Mast cell phenotype, location, and activation in severe asthma: Data from the severe asthma research program
    • Balzar S, Fajt ML, Comhair SA, et al. Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. Am J Respir Crit Care Med 2011; 183:299-309.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 299-309
    • Balzar, S.1    Fajt, M.L.2    Comhair, S.A.3
  • 61
    • 77951665424 scopus 로고    scopus 로고
    • Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum gran-ulocytes
    • Hastie AT, Moore WC, Meyers DA, et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum gran-ulocytes. J Allergy Clin Immunol 2010; 125:1028-1036.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1028-1036
    • Hastie, A.T.1    Moore, W.C.2    Meyers, D.A.3
  • 62
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
    • Miranda C, Busacker A, Balzar S, et al. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004; 113:101-108.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3
  • 63
    • 0343527389 scopus 로고    scopus 로고
    • Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance
    • Ordonez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med 2000; 161:1185-1190.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1185-1190
    • Ordonez, C.L.1    Shaughnessy, T.E.2    Matthay, M.A.3    Fahy, J.V.4
  • 64
    • 37549004387 scopus 로고    scopus 로고
    • Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    • Shaw DE, Berry MA, Hargadon B, et al. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest 2007; 132:1871-1875.
    • (2007) Chest , vol.132 , pp. 1871-1875
    • Shaw, D.E.1    Berry, M.A.2    Hargadon, B.3
  • 65
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160:1001-1008.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3
  • 66
    • 0035177659 scopus 로고    scopus 로고
    • Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    • Woodruff PG, Khashayar R, Lazarus SC, et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 2001; 108:753-758.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 753-758
    • Woodruff, P.G.1    Khashayar, R.2    Lazarus, S.C.3
  • 67
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008; 372: 1107-1119.
    • (2008) Lancet , vol.372 , pp. 1107-1119
    • Anderson, G.P.1
  • 68
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
    • Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-360.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 355-360
    • Lotvall, J.1    Akdis, C.A.2    Bacharier, L.B.3
  • 69
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176:1062-1071.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 70
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003; 167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 72
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088-1098.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 74
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    • Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009; 179:549-558.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 549-558
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3
  • 75
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, double-blind, sham-controlled clinical trial
    • Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 2010; 181:116-124.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette, M.3
  • 76
    • 34047099762 scopus 로고    scopus 로고
    • Asthma control during the year after bronchial thermoplasty
    • Cox G, Thomson NC, Rubin AS, et al. Asthma control during the year after bronchial thermoplasty. N Engl J Med 2007; 356:1327-1337.
    • (2007) N Engl J Med , vol.356 , pp. 1327-1337
    • Cox, G.1    Thomson, N.C.2    Rubin, A.S.3
  • 77
    • 21844445318 scopus 로고    scopus 로고
    • A prospective feasibility study of bronchial thermoplasty in the human airway
    • Miller JD, Cox G, Vincic L, et al. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest 2005; 127:1999-2006.
    • (2005) Chest , vol.127 , pp. 1999-2006
    • Miller, J.D.1    Cox, G.2    Vincic, L.3
  • 78
    • 37149034914 scopus 로고    scopus 로고
    • Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma
    • Pavord ID, Cox G, Thomson NC, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med 2007; 176:1185-1191.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1185-1191
    • Pavord, I.D.1    Cox, G.2    Thomson, N.C.3
  • 79
    • 33847690276 scopus 로고    scopus 로고
    • The art and science of personalized medicine
    • Piquette-Miller M, Grant DM. The art and science of personalized medicine. Clin Pharmacol Ther 2007; 81:311-315.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 311-315
    • Piquette-Miller, M.1    Grant, D.M.2
  • 80
    • 84856432513 scopus 로고    scopus 로고
    • New approaches to personalized medicine for asthma: Where are we?
    • Weiss ST. New approaches to personalized medicine for asthma: where are we? J Allergy Clin Immunol 2012; 129:327-334.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 327-334
    • Weiss, S.T.1


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