Biphasic action of aldosterone on akt signaling in cardiomyocytes

Hormone and Metabolic Research

Volumn 44, Issue 13, 2012, Pages 931-937

  Nagoshi, T ^a   Date, T ^a   Fujisaki, M ^a   Yoshino, T ^a   Sekiyama, H ^a   Ogawa, K ^a   Kayama, Y ^a   Minai, K ^a   Komukai, K ^a   Ogawa, T ^a   Yoshimura, M ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Akt; aldosterone; cardiomyocyte; insulin; mineralocorticoid receptor; Na + H+ exchanger 1

Indexed keywords

ALDOSTERONE; EPLERENONE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ALDOSTERONE; ANIMALS; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84871234414     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1316343     Document Type: Article

References (45)

1. Pitt B., Zannad F., Remme W. J., Cody R., Castaigne A., Perez A., Palensky J., Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med: 1999; 341 709 717
2. Pitt B., Remme W., Zannad F., Neaton J., Martinez F., Roniker B., Bittman R., Hurley S., Kleiman J., Gatlin M. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med: 2003; 348 1309 1321
3. Zannad F., McMurray J. J., Krum H., van Veldhuisen D. J., Swedberg K., Shi H., Vincent J., Pocock S. J., Pitt B. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med: 2011; 364 11 21
4. Rude M. K., Duhaney T. A., Kuster G. M., Judge S., Heo J., Colucci W. S., Siwik D. A., Sam F. Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes. Hypertension: 2005; 46 555 561
5. Mihailidou A. S., Loan Le T. Y., Mardini M., Funder J. W. Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension: 2009; 54 1306 1312
6. Rickard A. J., Morgan J., Tesch G., Funder J. W., Fuller P. J., Young M. J. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. Hypertension: 2009; 54 537 543
7. Funder J. W. Reconsidering the roles of the mineralocorticoid receptor. Hypertension: 2009; 53 286 290
8. Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension: 2010; 55 813 818
9. He B. J., Joiner M. L., Singh M. V., Luczak E. D., Swaminathan P. D., Koval O. M., Kutschke W., Allamargot C., Yang J., Guan X., Zimmerman K., Grumbach I. M., Weiss R. M., Spitz D. R., Sigmund C. D., Blankesteijn W. M., Heymans S., Mohler P. J., Anderson M. E. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med: 2011; 17 1610 1618
10. Catena C., Colussi G., Marzano L., Sechi L. A. Aldosterone and the heart: From basic research to clinical evidence. Horm Metab Res: 2012; 44 181 187
11. Mizuno Y., Yoshimura M., Yasue H., Sakamoto T., Ogawa H., Kugiyama K., Harada E., Nakayama M., Nakamura S., Ito T., Shimasaki Y., Saito Y., Nakao K. Aldosterone production is activated in failing ventricle in humans. Circulation: 2001; 103 72 77
12. Nakamura S., Yoshimura M., Nakayama M., Ito T., Mizuno Y., Harada E., Sakamoto T., Saito Y., Nakao K., Yasue H., Ogawa H. Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart. Circulation: 2004; 110 1787 1793
13. Chai W., Garrelds I. M., Arulmani U., Schoemaker R. G., Lamers J. M., Danser A. H. Genomic and nongenomic effects of aldosterone in the rat heart: Why is spironolactone cardioprotective? Br J Pharmacol: 2005; 145 664 671
14. Gros R., Ding Q., Sklar L. A., Prossnitz E. E., Arterburn J. B., Chorazyczewski J., Feldman R. D. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension: 2011; 57 442 451
15. Alzamora R., Michea L., Marusic E. T. Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries. Hypertension: 2000; 35 1099 1104
16. Grossmann C., Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol: 2009; 308 53 62
17. Wakabayashi S., Shigekawa M., Pouyssegur J. Molecular physiology of vertebrate Na+/H+ exchangers. Physiol Rev: 1997; 77 51 74
18. Karmazyn M., Kilic A., Javadov S. The role of NHE-1 in myocardial hypertrophy and remodelling. J Mol Cell Cardiol: 2008; 44 647 653
19. Karmazyn M., Liu Q., Gan X. T., Brix B. J., Fliegel L. Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension: 2003; 42 1171 1176
20. Matsui S., Satoh H., Kawashima H., Nagasaka S., Niu C. F., Urushida T., Katoh H., Watanabe Y., Hayashi H. Non-genomic effects of aldosterone on intracellular ion regulation and cell volume in rat ventricular myocytes. Can J Physiol Pharmacol: 2007; 85 264 273
21. Bandulik S., Penton D., Barhanin J., Warth R. TASK1 and TASK3 potassium channels: Determinants of aldosterone secretion and adrenocortical zonation. Horm Metab Res: 2010; 42 450 457
22. De Giusti V. C., Nolly M. B., Yeves A. M., Caldiz C. I., Villa-Abrille M. C., Chiappe de Cingolani G. E., Ennis I. L., Cingolani H. E., Aiello E. A. Aldosterone stimulates the cardiac Na+/H+ exchanger via transactivation of the epidermal growth factor receptor. Hypertension: 2011; 58 912 919
23. Yamamuro M., Yoshimura M., Nakayama M., Abe K., Shono M., Suzuki S., Sakamoto T., Saito Y., Nakao K., Yasue H., Ogawa H. Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium. Endocrinology: 2006; 147 1314 1321
24. Matsui T., Nagoshi T., Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle: 2003; 2 220 223
25. Matsui T., Nagoshi T., Hong E. G., Luptak I., Hartil K., Li L., Gorovits N., Charron M. J., Kim J. K., Tian R., Rosenzweig A. Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol and Metabol: 2006; 290 E789 E797
26. Matsui T., Li L., del Monte F., Fukui Y., Franke T. F., Hajjar R. J., Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation: 1999; 100 2373 2379
27. Aikawa R., Nawano M., Gu Y., Katagiri H., Asano T., Zhu W., Nagai R., Komuro I. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation: 2000; 102 2873 2879
28. Matsui T., Tao J., del Monte F., Lee K. H., Li L., Picard M., Force T. L., Franke T. F., Hajjar R. J., Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation: 2001; 104 330 335
29. Haq S., Choukroun G., Lim H., Tymitz K. M., del Monte F., Gwathmey J., Grazette L., Michael A., Hajjar R., Force T., Molkentin J. D. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation: 2001; 103 670 677
30. Nagoshi T., Matsui T., Aoyama T., Leri A., Anversa P., Li L., Ogawa W., Del Monte F., Gwathmey J. K., Grazette L., Hemmings B., Kass D. A., Champion H. C., Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest: 2005; 115 2128 2138
31. Liu S. L., Schmuck S., Chorazcyzewski J. Z., Gros R., Feldman R. D. Aldosterone regulates vascular reactivity: Short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation: 2003; 108 2400 2406
32. Holzman J. L., Liu L., Duke B. J., Kemendy A. E., Eaton D. C. Transactivation of the IGF-1R by aldosterone. Am J Physiol Renal Physiol: 2007; 292 F1219 F1228
33. Bunda S., Wang Y., Mitts T. F., Liu P., Arab S., Arabkhari M., Hinek A. Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt. J Biol Chem: 2009; 284 16633 16647
34. Hitomi H., Kiyomoto H., Nishiyama A., Hara T., Moriwaki K., Kaifu K., Ihara G., Fujita Y., Ugawa T., Kohno M. Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension: 2007; 50 750 755
35. Wada T., Ohshima S., Fujisawa E., Koya D., Tsuneki H., Sasaoka T. Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and irs2 via a reactive oxygen species-mediated pathway in 3t3-l1 adipocytes. Endocrinology: 2009; 150 1662 1669
36. Date T., Taniguchi I., Inada K., Matsuo S., Miyanaga S., Yamane T., Abe Y., Sugimoto K., Mochizuki S. Nicorandil inhibits serum starvation-induced apoptosis in vascular endothelial cells. J Cardiovasc Pharmacol: 2005; 46 721 726
37. Wu K. L., Khan S., Lakhe-Reddy S., Jarad G., Mukherjee A., Obejero-Paz C. A., Konieczkowski M., Sedor J. R., Schelling J. R. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem: 2004; 279 26280 26286
38. Kilic A., Velic A., De Windt L. J., Fabritz L., Voss M., Mitko D., Zwiener M., Baba H. A., van Eickels M., Schlatter E., Kuhn M. Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation: 2005; 112 2307 2317
39. Darmellah A., Baetz D., Prunier F., Tamareille S., Rucker-Martin C., Feuvray D. Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the goto-kakizaki rat model of type 2 diabetes: Critical role of Akt. Diabetologia: 2007; 50 1335 1344
40. Snabaitis A. K., Cuello F., Avkiran M. Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circ Res: 2008; 103 881 890
41. Mano A., Tatsumi T., Shiraishi J., Keira N., Nomura T., Takeda M., Nishikawa S., Yamanaka S., Matoba S., Kobara M., Tanaka H., Shirayama T., Takamatsu T., Nozawa Y., Matsubara H. Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways. Circulation: 2004; 110 317 323
42. Messaoudi S., Milliez P., Samuel J. L., Delcayre C. Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density. FASEB J: 2009; 23 2176 2185
43. Shiojima I., Sato K., Izumiya Y., Schiekofer S., Ito M., Liao R., Colucci W. S., Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest: 2005; 115 2108 2118
44. Freel E. M., Tsorlalis I. K., Lewsey J. D., Latini R., Maggioni A. P., Solomon S., Pitt B., Connell J. M., McMurray J. J. Aldosterone status associated with insulin resistance in patients with heart failure - data from the aloft study. Heart: 2009; 95 1920 1924
45. Nagoshi T., Yoshimura M., Rosano G. M., Lopaschuk G. D., Mochizuki S. Optimization of cardiac metabolism in heart failure. Curr Pharm Des: 2011; 17 3846 3853