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Volumn 44, Issue 3, 2012, Pages 181-187

Aldosterone and the heart: From basic research to clinical evidence

Author keywords

arrhythmia; atrial fibrillation; essential hypertension; heart failure; mineralocorticoid receptor antagonists; primary aldosteronism; spironolactone

Indexed keywords

ALDOSTERONE; CANRENONE; ENALAPRIL; EPLERENONE; PLACEBO; SPIRONOLACTONE;

EID: 84858002935     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0031-1291318     Document Type: Review
Times cited : (53)

References (59)
  • 1
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • DOI 10.1056/NEJM199909023411001
    • Pitt B, Zannad F, Remme W J, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect ofspironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717 (Pubitemid 29407370)
    • (1999) New England Journal of Medicine , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 4
    • 0029022285 scopus 로고
    • Prerequisite for cardiac aldosterone action: Mineralocorticoid receptor and 11-β-hydroxysteroid dehydrogenase in the human heart
    • Lombes M, Alfaidy N, Eugene E, Lessana A, Farman A, Bonvalet J P. Prerequisite for cardiac aldosterone action: mineralocorticoid receptor and 11-β-hydroxysteroid dehydrogenase in the human heart. Circulation 1995; 92: 175-182
    • (1995) Circulation , vol.92 , pp. 175-182
    • Lombes, M.1    Alfaidy, N.2    Eugene, E.3    Lessana, A.4    Farman, A.5    Bonvalet, J.P.6
  • 5
    • 34548500119 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • DOI 10.1042/CS20070123
    • Marney A M, Brown N J. Aldosterone and end-organ damage. Clin Sci 2007; 113: 267-278 (Pubitemid 47372685)
    • (2007) Clinical Science , vol.113 , Issue.5-6 , pp. 267-278
    • Marney, A.M.1    Brown, N.J.2
  • 9
    • 33644895071 scopus 로고    scopus 로고
    • Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
    • DOI 10.1139/y05-068
    • Neves M F, Amiri F, Virdis A, Diep Q N, Schiffrin E L; CIHR Multidisciplinary Research Group on Hypertension. Role ofaldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy. Can J Physiol Pharmacol 2005; 83: 999-1006 (Pubitemid 43385544)
    • (2005) Canadian Journal of Physiology and Pharmacology , vol.83 , Issue.11 , pp. 999-1006
    • Neves, M.F.1    Amiri, F.2    Virdis, A.3    Diep, Q.N.4    Schiffrin, E.L.5
  • 10
    • 0037180412 scopus 로고    scopus 로고
    • Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: Effects of eplerenone
    • DOI 10.1161/01.CIR.0000039328.33137.6C
    • Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salttreated rats: effects ofeplerenone. Circulation 2002; 106: 2848-2853 (Pubitemid 35396986)
    • (2002) Circulation , vol.106 , Issue.22 , pp. 2848-2853
    • Lacolley, P.1    Labat, C.2    Pujol, A.3    Delcayre, C.4    Benetos, A.5    Safar, M.6
  • 14
    • 33645822083 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
    • DOI 10.1161/01.HYP.0000203148.42892.7a, PII 0000426820060400000014
    • Kobayashi N, Yoshida K, Nakano S, Ohno T, Honda T, Tsubokou Y, Matsuoka H. Cardioprotective mechanisms ofeplerenone on cardiac performance and remodeling in failing rat hearts. Hypertension 2006; 47: 671-679 (Pubitemid 43740237)
    • (2006) Hypertension , vol.47 , Issue.4 , pp. 671-679
    • Kobayashi, N.1    Yoshida, K.2    Nakano, S.3    Ohno, T.4    Honda, T.5    Tsubokou, Y.6    Matsuoka, H.7
  • 16
    • 79955064277 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade improve diastolic function independent ofblood pressure reduction in a transgenic model ofRAAS overexpression
    • Habibi J, DeMarco V G, Ma L, Pulakat L, Rainey W E, Whaley-Connell A T, Sowers J R. Mineralocorticoid receptor blockade improve diastolic function independent ofblood pressure reduction in a transgenic model ofRAAS overexpression. Am J Physiol Heart Circ Physiol 2002; 300: H1484-H1491
    • (2002) Am J Physiol Heart Circ Physiol , vol.300
    • Habibi, J.1    DeMarco, V.G.2    Ma, L.3    Pulakat, L.4    Rainey, W.E.5    Whaley-Connell, A.T.6    Sowers, J.R.7
  • 19
    • 16444375794 scopus 로고    scopus 로고
    • Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells
    • DOI 10.1161/01.RES.0000159937.05502.d1
    • Jaffe I Z, Mendelsohn M E. Angiotensin II and aldosterone regulate gene transcription via functional mineralocorticoid receptors in human coronary artery smooth muscle cell. Circ Res 2005; 96: 643-650 (Pubitemid 40478331)
    • (2005) Circulation Research , vol.96 , Issue.6 , pp. 643-650
    • Jaffe, I.Z.1    Mendelsohn, M.E.2
  • 23
    • 50549212658 scopus 로고
    • Clinical characteristics ofprimary aldosteronism from an analysis of145 cases
    • Conn J W, KnopfR F, Nesbit R M. Clinical characteristics ofprimary aldosteronism from an analysis of145 cases. Am J Surg 1964; 107: 159-172
    • (1964) Am J Surg , vol.107 , pp. 159-172
    • Conn, J.W.1    Knopf, R.F.2    Nesbit, R.M.3
  • 24
    • 77952895143 scopus 로고    scopus 로고
    • Progress in primary aldosteronism: Present challenges and perspectives
    • Gomez-Sanchez C E, Rossi G P, Fallo F, Mannelli M. Progress in primary aldosteronism: present challenges and perspectives. Horm Metab Res 2010; 42: 374-381
    • (2010) Horm Metab Res , vol.42 , pp. 374-381
    • Gomez-Sanchez, C.E.1    Rossi, G.P.2    Fallo, F.3    Mannelli, M.4
  • 25
    • 0015868444 scopus 로고
    • Vasoconstriction-Volume analysis for understanding and treating hypertension: The use ofrenin and aldosterone profiles
    • Laragh J H. Vasoconstriction-Volume analysis for understanding and treating hypertension: the use ofrenin and aldosterone profiles. Am J Med 1973; 55: 261-274
    • (1973) Am J Med , vol.55 , pp. 261-274
    • Laragh, J.H.1
  • 26
    • 1942518234 scopus 로고    scopus 로고
    • Is aldosterone bad for the heart?
    • DOI 10.1016/j.tem.2004.03.006, PII S104327600400061X
    • Funder J W. Is aldosterone bad for the heart? Trends Endocrinol Metab 2004; 15: 139-142 (Pubitemid 38510491)
    • (2004) Trends in Endocrinology and Metabolism , vol.15 , Issue.4 , pp. 139-142
    • Funder, J.W.1
  • 31
    • 70349260701 scopus 로고    scopus 로고
    • The dual role ofthe kidney in primary aldosteronism: Key determinant in rescue from volume expansion and persistence ofhypertension
    • Sechi L A, Catena C. The dual role ofthe kidney in primary aldosteronism: key determinant in rescue from volume expansion and persistence ofhypertension. Am J Kidney Dis 2009; 54: 594-597
    • (2009) Am J Kidney Dis , vol.54 , pp. 594-597
    • Sechi, L.A.1    Catena, C.2
  • 32
    • 79952277181 scopus 로고    scopus 로고
    • Cardiovascular and renal damage in primary aldosteronism: Outcomes after treatment
    • Sechi L A, Colussi G L, Di Fabio A, Catena C. Cardiovascular and renal damage in primary aldosteronism: outcomes after treatment. Am J Hypertens 2010; 12: 1253-1260
    • (2010) Am J Hypertens , vol.12 , pp. 1253-1260
    • Sechi, L.A.1    Colussi, G.L.2    Di Fabio, A.3    Catena, C.4
  • 33
    • 33846257337 scopus 로고    scopus 로고
    • Increased Arterial Wall Stiffness in Primary Aldosteronism in Comparison With Essential Hypertension
    • DOI 10.1016/j.amjhyper.2006.02.002, PII S089570610600121X
    • Strauch B, Petrák O, Wichterle D, Zelinka T, Holaj R, Widimsky J Jr. Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension. Am J Hypertens 2006; 19: 909-914 (Pubitemid 46106987)
    • (2006) American Journal of Hypertension , vol.19 , Issue.9 , pp. 909-914
    • Strauch, B.1    Petrak, O.2    Wichterle, D.3    Zelinka, T.4    Holaj, R.5    Widimsky Jr., J.6
  • 34
    • 34250313556 scopus 로고    scopus 로고
    • Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension
    • DOI 10.1097/HJH.0b013e3281268532, PII 0000487220070700000022
    • Holaj R, Zelinka T, Wichterle D, Petrák O, Strauch B, Widimsky J Jr. Increased intima media thickness ofthe common carotid artery in primary aldosteronism in comparison with essential hypertension. J Hypertens 2007; 25: 1451-1457 (Pubitemid 46918833)
    • (2007) Journal of Hypertension , vol.25 , Issue.7 , pp. 1451-1457
    • Holaj, R.1    Zelinka, T.2    Wichterle, D.3    Petrak, O.4    Strauch, B.5    Widimsky Jr., J.6
  • 38
    • 35848931662 scopus 로고    scopus 로고
    • Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism
    • DOI 10.1161/HYPERTENSIONAHA.107.095448
    • Catena C, Colussi G, Lapenna R, Nadalini E, Chiuch A, Gianfagna P, Sechi L A. Long-term cardiac effects ofadrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism. Hypertension 2007; 50: 911-918 (Pubitemid 350287534)
    • (2007) Hypertension , vol.50 , Issue.5 , pp. 911-918
    • Catena, C.1    Colussi, G.2    Lapenna, R.3    Nadalini, E.4    Chiuch, A.5    Gianfagna, P.6    Sechi, L.A.7
  • 39
    • 84858008319 scopus 로고    scopus 로고
    • Treatment ofprimary aldosteronism: Short and middle-term effects ofmedical and surgical therapy in primary hyperaldosteronism: Experience of45 cases
    • Cicala M, Cesari M, Patalano A, Iacobone M, Mariniello B, Mantero F. Treatment ofprimary aldosteronism: short and middle-term effects ofmedical and surgical therapy in primary hyperaldosteronism: experience of45 cases. J Hypertens 2010; 28 (e-Supplement A) : 305
    • (2010) J Hypertens , vol.28 , Issue.E-SUPPLEMENT A , pp. 305
    • Cicala, M.1    Cesari, M.2    Patalano, A.3    Iacobone, M.4    Mariniello, B.5    Mantero, F.6
  • 43
    • 84858008546 scopus 로고    scopus 로고
    • Cardiovascular complications in patients with primary hyperaldosteronism: A controlled cross-sectional study
    • Steichen O, Amar L, Plouin P F. Cardiovascular complications in patients with primary hyperaldosteronism: a controlled cross-sectional study. J Hypertens 2010; 28 (e-Supplement A1) : e-301
    • (2010) J Hypertens , vol.28 , Issue.E-SUPPLEMENT A1
    • Steichen, O.1    Amar, L.2    Plouin, P.F.3
  • 45
    • 0142085752 scopus 로고    scopus 로고
    • Effects of Eplerenone, Enalapril, and Eplerenone/Enalapril in Patients With Essential Hypertension and Left Ventricular Hypertrophy: The 4E-Left Ventricular Hypertrophy Study
    • DOI 10.1161/01.CIR.0000091405.00772.6E
    • Pitt B, Reichek N, Willenbrock R, Zannad F, Phillips R A, Roniker B, Kleiman J, Krazuse S, Burns D, Williams GH. Effects ofeplerenone, enalalpril, and eplerenone/enelapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108: 1831-1838 (Pubitemid 37296092)
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3    Zannad, F.4    Phillips, R.A.5    Roniker, B.6    Kleiman, J.7    Krause, S.8    Burns, D.9    Williams, G.H.10
  • 46
    • 3543099842 scopus 로고    scopus 로고
    • Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure
    • DOI 10.1161/01.CIR.0000138680.89536.A9
    • Mottram P M, Haluska B, Leano R, Cowley D, Stowasser M, Marwick TH. Effect ofaldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation 2004; 110: 558-565 (Pubitemid 39031173)
    • (2004) Circulation , vol.110 , Issue.5 , pp. 558-565
    • Mottram, P.M.1    Haluska, B.2    Leano, R.3    Cowley, D.4    Stowasser, M.5    Marwick, T.H.6
  • 48
    • 77955981023 scopus 로고    scopus 로고
    • Hyperaldosteronism and left ventricular hypertrophy
    • Sechi L A, Colussi G L, Catena C. Hyperaldosteronism and left ventricular hypertrophy. Hypertension 2010; 56: e26
    • (2010) Hypertension , vol.56
    • Sechi, L.A.1    Colussi, G.L.2    Catena, C.3
  • 52
    • 78149424364 scopus 로고    scopus 로고
    • Effect ofspironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease
    • Edwards N C, Ferro C J, Kirkwood H, Chue C D, Young A A, Stewart P M, Steeds R P, Townsends J N. Effect ofspironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease. Am J Cardiol 2010; 106: 1505-1511
    • (2010) Am J Cardiol , vol.106 , pp. 1505-1511
    • Edwards, N.C.1    Ferro, C.J.2    Kirkwood, H.3    Chue, C.D.4    Young, A.A.5    Stewart, P.M.6    Steeds, R.P.7    Townsends, J.N.8
  • 54
    • 78649322746 scopus 로고    scopus 로고
    • Effect combined spironolactone-β blocker±enalapril treatment on occurrence ofsymptomatic atrial fibrillation episodes in patients with a history ofparoxysmal atrial fibrillation (SPIR-Afstudy)
    • Dabrowski R, Borowiec A, Smolis-Bak E, Kowalik I, Sosnowski C, Kraska A, Kazimierska B, Wozniak J, Zareba W, Szwed H. Effect combined spironolactone-β blocker±enalapril treatment on occurrence ofsymptomatic atrial fibrillation episodes in patients with a history ofparoxysmal atrial fibrillation (SPIR-Afstudy). Am J Cardiol 2010; 206: 1609-1614
    • (2010) Am J Cardiol , vol.206 , pp. 1609-1614
    • Dabrowski, R.1    Borowiec, A.2    Smolis-Bak, E.3    Kowalik, I.4    Sosnowski, C.5    Kraska, A.6    Kazimierska, B.7    Wozniak, J.8    Zareba, W.9    Szwed, H.10
  • 55
    • 34247157767 scopus 로고    scopus 로고
    • Spironolactone Reduced Arrhythmia and Maintained Magnesium Homeostasis in Patients With Congestive Heart Failure
    • DOI 10.1016/j.cardfail.2006.11.015, PII S1071916406012589
    • Gao X, Peng L, Adhikari C M, Lin J, Zuo Z. Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. J Card Fail 2007; 13: 170-177 (Pubitemid 46591953)
    • (2007) Journal of Cardiac Failure , vol.13 , Issue.3 , pp. 170-177
    • Gao, X.1    Peng, L.2    Adhikari, C.M.3    Lin, J.4    Zuo, Z.5
  • 56
    • 51749105033 scopus 로고    scopus 로고
    • Aldosterone synthase gene polymorphism as a determinant ofatrial fibrillation in patients with heart failure
    • Amir O, Amir R E, Paz H, Mor R, Sagiy M, Lewis B S. Aldosterone synthase gene polymorphism as a determinant ofatrial fibrillation in patients with heart failure. Am J Cardiol 2008; 102: 326-329
    • (2008) Am J Cardiol , vol.102 , pp. 326-329
    • Amir, O.1    Amir, R.E.2    Paz, H.3    Mor, R.4    Sagiy, M.5    Lewis, B.S.6
  • 58
    • 76449088802 scopus 로고    scopus 로고
    • Aldosterone signaling in atrial fibrillation. Another piece in the puzzle ofatrial remodeling
    • Korantzopoulos P, Goudevenos J A. Aldosterone signaling in atrial fibrillation. Another piece in the puzzle ofatrial remodeling. J Am Coll Cardiol 2010; 55: 771-773
    • (2010) J Am Coll Cardiol , vol.55 , pp. 771-773
    • Korantzopoulos, P.1    Goudevenos, J.A.2
  • 59
    • 77956910160 scopus 로고    scopus 로고
    • The effect ofaldosterone antagonists for ventricular arrhythmia: A metaanalysis
    • Wei J, Ni J, Huang D, Chen M, Yan S, Peng Y. The effect ofaldosterone antagonists for ventricular arrhythmia: a metaanalysis. Clin Cardiol 2010; 9: 572-577
    • (2010) Clin Cardiol , vol.9 , pp. 572-577
    • Wei, J.1    Ni, J.2    Huang, D.3    Chen, M.4    Yan, S.5    Peng, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.