Radiation-induced enteropathy: Molecular basis of pentoxifylline-vitamin e anti-fibrotic effect involved TGF-β1 cascade inhibition

Radiotherapy and Oncology

Volumn 105, Issue 3, 2012, Pages 305-312

  Hamama, Saad ^a   Gilbert Sirieix, Marie ^b   Vozenin, Marie Catherine ^a   Delanian, Sylvie ^c  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b IRCCS   (Italy)

^c SAINT LOUIS HOSPITAL   (France)

Author keywords

Pentoxifylline; Radiation enteropathy; Radiation induced fibrosis; Rho ROCK; TGF 1; Tocopherol

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; PENTOXIFYLLINE; RHO FACTOR; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TROLOX C;

ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; ENTEROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINE MUSCLE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INDUCED ENTEROPATHY; REMISSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SMOOTH MUSCLE FIBER; SUBJECTIVE OBJECTIVE MANAGEMENT ANALYTIC SCORE; WESTERN BLOTTING;

ADULT; AGED; ALGORITHMS; ANTIOXIDANTS; BLOTTING, WESTERN; CLINICAL TRIALS AS TOPIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL DISEASES; MALE; MIDDLE AGED; PENTOXIFYLLINE; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME; VITAMIN E;

EID: 84871200071     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.08.023     Document Type: Article

References (48)

1. C. Bourgier, V. Haydont, and F. Milliat Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression Gut 54 2005 336 343 (Pubitemid 40299087)
2. J. Andreyev Gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut 54 2005 1051 1054 (Pubitemid 41025889)
3. H.J. Andreyev, S.E. Davidson, C. Gillespie, W.H. Allum, and E. Swarbrick Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer Gut 61 2011 179 192
4. A.C. Begg, F.A. Stewart, and C. Vens Strategies to improve radiotherapy with targeted drugs Nat Rev Cancer 11 2011 239 253
5. J. Andreyev Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients Lancet Oncol 8 2007 1007 1017 (Pubitemid 47629896)
6. J.L. Lefaix, S. Delanian, M.C. Vozenin, J.J. Leplat, Y. Tricaud, and M. Martin Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study Int J Radiat Oncol Biol Phys 43 1999 839 847 (Pubitemid 29152657)
7. M. Boerma, K.A. Roberto, and M. Hauer-Jensen Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol Int J Radiat Oncol Biol Phys 72 2008 170 177
8. S. Delanian, S. Balla-Mekias, and J.L. Lefaix Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol J Clin Oncol 17 1999 3283 3290 (Pubitemid 29470664)
9. S. Delanian, R. Porcher, S. Balla-Mekias, and J.L. Lefaix Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis J Clin Oncol 21 2003 2545 2550 (Pubitemid 46606336)
10. S. Delanian, R. Porcher, J. Rudant, and J.L. Lefaix Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis J Clin Oncol 23 2005 8570 8579 (Pubitemid 46211498)
11. S. Delanian, J.L. Lefaix, T. Maisonobe, F. Salachas, and P.F. Pradat Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo) J Neurol Sci 275 2008 164 166
12. S. Delanian, C. Chatel, R. Porcher, J. Depondt, and J.L. Lefaix Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial Int J Radiat Oncol Biol Phys 80 2011 832 839
13. P. Haddad, B. Kalaghchi, and F. Amouzegar-Hashemi Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial Radiother Oncol 77 2005 324 326 (Pubitemid 41785344)
14. A. Hille, H. Christiansen, and O. Pradier Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis Strahlenther Onkol 181 2005 606 614 (Pubitemid 41346201)
15. T.B. Chiao, and A.J. Lee Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis Ann Pharmacother 39 2005 516 522 (Pubitemid 40270918)
16. M. Martin, J. Lefaix, and S. Delanian TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 47 2000 277 290 (Pubitemid 30236366)
17. J. Yarnold, and M.C. Brotons Pathogenetic mechanisms in radiation fibrosis Radiother Oncol 97 2010 149 161
18. P.W. Noble, C. Albera, and W.Z. Bradford Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials Lancet 377 2011 1760 1769
19. V. Haydont, D. Mathe, and C. Bourgier Induction of CTGF by TGF-beta1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives Radiother Oncol 76 2005 219 225 (Pubitemid 41725451)
20. P. Gervaz, P. Morel, and M.C. Vozenin-Brotons Molecular aspects of intestinal radiation-induced fibrosis Curr Mol Med 9 2009 273 280
21. V. Monceau, N. Pasinetti, C. Schupp, F. Pouzoulet, P. Opolon, and M.C. Vozenin Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity Curr Drug Targets 11 2010 1395 1404
22. J. Wang, M. Boerma, Q. Fu, A. Kulkarni, L.M. Fink, and M. Hauer-Jensen Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism Int J Radiat Oncol Biol Phys 68 2007 1483 1490 (Pubitemid 47176821)
23. J.P. Williams, E. Hernady, and C.J. Johnston Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model Radiat Res 161 2004 560 567 (Pubitemid 40754225)
24. Late Effects of Normal Tissues Consensus Conference. San Francisco, California, August 26-28, 1992. Int J Radiat Oncol Biol Phys 1995;31:1035-1367.
25. S. Delanian, and J.L. Lefaix Current management for late normal tissue injury: radiation-induced fibrosis and necrosis Semin Radiat Oncol 17 2007 99 107 (Pubitemid 46476864)
26. L. Gothard, P. Cornes, and S. Brooker Phase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy Radiother Oncol 75 2005 334 341 (Pubitemid 41007980)
27. C. Laurent, J.P. Pouget, and P. Voisin Modulation of DNA damage by pentoxifylline and alpha-tocopherol in skin fibroblasts exposed to gamma rays Radiat Res 164 2005 63 72 (Pubitemid 40885231)
28. P. Chen, C. Peng, and J. Luff Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice J Neurosci 23 2003 11453 11460 (Pubitemid 37549702)
29. M. Eberlein, J. Heusinger-Ribeiro, and M. Goppelt-Struebe Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins) Br J Pharmacol 133 2001 1172 1180 (Pubitemid 32762429)
30. M. Lohn, O. Plettenburg, and Y. Ivashchenko Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor Hypertension 54 2009 676 683
31. B. Horvath, Z. Marton, and R. Halmosi In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine Clin Neuropharmacol 25 2002 37 42 (Pubitemid 34178247)
32. B. Berman, and M.R. Duncan Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity J Invest Dermatol 92 1989 605 610 (Pubitemid 19122118)
33. B. Berman, and M.R. Duncan Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin Br J Dermatol 123 1990 339 346 (Pubitemid 20265379)
34. M.R. Duncan, A. Hasan, and B. Berman Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation J Invest Dermatol 104 1995 282 286
35. R. Janknecht, N.J. Wells, and T. Hunter TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300 Genes Dev 12 1998 2114 2119 (Pubitemid 28348035)
36. C. Pouponnot, L. Jayaraman, and J. Massague Physical and functional interaction of SMADs and p300/CBP J Biol Chem 273 1998 22865 22868 (Pubitemid 28417457)
37. M. Schiller, F. Verrecchia, and A. Mauviel Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism Oncogene 22 2003 8881 8890 (Pubitemid 38021504)
38. W. Zhao, D.I. Diz, and M.E. Robbins Oxidative damage pathways in relation to normal tissue injury Br J Radiol 80 2007 S23 S31
39. J. Yarnold, and M.C. Brotons Pathogenetic mechanisms in radiation fibrosis Radiother Oncol 97 2010 149 161
40. S. Delanian, and J.L. Lefaix The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway Radiother Oncol 73 2004 119 131 (Pubitemid 39470150)
41. D. Boscoboinik, A. Szewczyk, C. Hensey, and A. Azzi Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C J Biol Chem 266 1991 6188 6194 (Pubitemid 21906202)
42. L. Villacorta, A.V. Graca-Souza, R. Ricciarelli, J.M. Zingg, and A. Azzi Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cells Circ Res 92 2003 104 110 (Pubitemid 36105613)
43. A. Azzi, R. Gysin, and P. Kempna Vitamin E mediates cell signaling and regulation of gene expression Ann N Y Acad Sci 1031 2004 86 95 (Pubitemid 40361745)
44. R. Ricciarelli, P. Maroni, N. Ozer, J.M. Zingg, and A. Azzi Age-dependent increase of collagenase expression can be reduced by alpha-tocopherol via protein kinase C inhibition Free Radic Biol Med 27 1999 729 737 (Pubitemid 29454575)
45. A.L. Akeson, C.W. Woods, L.B. Mosher, C.E. Thomas, and R.L. Jackson Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol Atherosclerosis 86 1991 261 270
46. M. Chojkier, K. Houglum, K.S. Lee, and M. Buck Long- and short-term d-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression Am J Physiol 275 1998 G1480 1485
47. C. Cojocel, M. Al-Maghrebi, M.S. Thomson, P. Rawoot, and R. Raghupathy Modulation of the transforming growth factor beta1 by vitamin E in early nephropathy Med Princ Pract 14 2005 422 429 (Pubitemid 41442848)
48. S. Devaraj, A.V. Chan Jr, and I. Jialal Alpha-Tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients Diabetes Care 25 2002 524 529 (Pubitemid 41103347)