Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis

Annals of Pharmacotherapy

Volumn 39, Issue 3, 2005, Pages 516-522

  Chiao, Teresa B ^a,b,c   Lee, Audrey J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF THE PACIFIC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

tocopherol; Pentoxifylline; Radiation induced fibrosis; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; PENTOXIFYLLINE;

ANTIOXIDANT ACTIVITY; ARTICLE; ASTHENIA; DRUG TOLERABILITY; DYSPEPSIA; EPIGASTRIC PAIN; FIBROSIS; GASTROINTESTINAL DISEASE; HEADACHE; HOT FLUSH; HUMAN; INSOMNIA; MEDLINE; NAUSEA; NERVOUSNESS; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION ATTENUATION; RADIATION INJURY; SOFT TISSUE INJURY; VERTIGO;

ANTIOXIDANTS; CLINICAL TRIALS; DRUG THERAPY, COMBINATION; FIBROSIS; HUMANS; PENTOXIFYLLINE; PLATELET AGGREGATION INHIBITORS; RADIATION INJURIES; VITAMIN E;

EID: 13944261884     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1E186     Document Type: Article

References (30)

1. Davis AM, Dische S, Gerber L, Sanders M, Leung SF, O'Sullivan B. Measuring postirradiation subcutaneous soft-tissue fibrosis: state-of-art and future directions. Semin Radiat Oncol 2003;13:203-13.
2. O'Sullivan B, Levin W. Late radiation-related fibrosis; pathogenesis, manifestations, and current management. Semin Radiat Oncol 2003;13: 274-89.
3. Package insert. Trental (pentoxifylline). Bridgewater, NJ: Aventis Pharmaceuticals, May 2002.
4. Moulder JE. Pharmacological intervention to prevent or ameliorate chronic radiation injuries. Semin Radiat Oncol 2003;13:73-84.
5. Hom DB, Adams GL, Monyak D. Irradiated soft tissue and its management. Otolaryngol Clin North Am 1995;28:1003-17.
6. Border WA, Noble NA. Transforming growth factor B in tissue fibrosis. N Engl J Med 1994;331:1286-92.
7. 1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 2000;42:277-90.
8. Denham J, Hauer-Jensen M. The radiotherapeutic injury - a complex wound. Radiother Oncol 2002;63:129-45.
9. Peter RU, Gottlober P, Nadeshina N, Krahn G, Braun-Falco O, Plewig G. Interferon gamma in survivors of the Chernobyl power plant accident: new therapeutic option for radiation-induced fibrosis. Int J Radiat Oncol Biol Phys 1999;45:147-52.
10. Pavy J-J, Denekamp J, Letschert B, Littbrand B, Mornex F, Bernier J, et al. EORTC late effects working group. Late effects toxicity scoring: the SOMA scale. Radiother Oncol 1995;35:11-5.
11. Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 1999;17:3283-90.
12. Delanian S, Porcher R, Balla-Mekias S, Lefaix JL. Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. J Clin Oncol 2003;21: 2545-50.
13. Bauer W. Electrical treatment of severe head and neck cancer pain. Arch Otolaryngol 1983;109:382-3.
14. Lennox AJ, Shafer JP, Hatcher M, Beil J, Funder SJ. Pilot study of impedance-controlled microcurrent therapy for managing radiation-induced fibrosis in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2002;54:23-34.
15. Lefaix JL, Delanian S, Leplat JJ, Tricaud Y, Martin M, Nimrod A, et al. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study. Int J Radiat Oncol Oncol Biol Phys 1996;35:305-12.
16. Delanian S, Baillet F, Huart J, Lefaix JL, Maulard C, Housset M. Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial. Radiother Oncol 1994;32:12-20.
17. Delanian S, Martin M, Bravard A, Luccioni C, Lefaix JL. Cu/Zn superoxide dismutase modulates phenotypic changes in cultured fibroblasts from human skin with chronic radiotherapy damage. Radiother Oncol 2001;58:325-31.
18. Gottlober P, Steinert M, Bahren W, Weber L, Gerngross H, Peter RU. Interferon-gamma in 5 patients with cutaneous radiation syndrome after radiation therapy. Int J Radiat Oncol Biol Phys 2001;50:159-66.
19. Package insert. Actimmune (Interferon gamma-1b). Brisbane, CA: Intermune, May 2003.
20. Lefaix JL, Delanian S, Vozenin MC, Leplat JJ, Tricaud Y, Martin M. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study. Int J Radiat Oncol Biol Phys 1999;43:839-47.
21. Baillet F. Alpha-tocopherol treatment of radiofibrosis post-brachytherapy for breast cancer (abstract 9). Radiother Oncol 1997;97(suppl 43):S3.
22. Berman B, Duncan M. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminogylycan, and fibronectin production, and increases collagenase activity. J Invest Dermatol 1989;92:605-10.
23. Dion MW, Hussey DH, Osborne JW. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys 1989;17:101-7.
24. Werner-Wasik M, Madoc-Jones H. Trental (pentoxifylline) relieves pain from postradiation fibrosis. Int J Radiat Oncol Biol Phys 1993;25:757-8.
25. Dion MW, Hussey DH, Doornbos JF, Vigliotti AP, Wen BC, Anderson B. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int J Radiat Oncology Biol Phys 1990;19:401-7.
26. Futran ND, Trotti A, Gwede C. Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. Laryngoscope 1997;107:391-5.
27. Cornelison TL, Okunieff P, Naydich BG, Hicks J, Klaiman M, Ding I, et al. Trial of pentoxifylline in patients with functional disability caused by radiation-induced advanced regional fibrosis: preliminary report (abstract 4185). Proc Am Assoc Cancer Res 1996;37:610.
28. Delanian S. Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol. Br J Radiol 1998;71:892-4.
29. Fischer M, Wohlrab J, Marsch WC. Crux medicorum ulcerated radiation-induced fibrosis - successful therapy with pentoxifylline and vitamin E. Eur J Dermatol 2001;11:38-40.
30. Delanian S, Lefaix JL. Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. Br J Radiol 2002;75:467-9.