Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): A phase II trial

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 3, 2011, Pages 832-839

  Delanian, Sylvie ^a   Chatel, Cécile ^b   Porcher, Raphael ^a   Depondt, Joel ^c   Lefaix, Jean Louis ^d  

^a SAINT LOUIS HOSPITAL   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c BICHAT HOSPITAL   (France)

^d Centre Interdisciplinaire de Recherche Ions Lasers   (France)

Author keywords

Alpha tocopherol; Clodronate; Osteoradionecrosis; Pentoxifylline; Radiotherapy

Indexed keywords

ALPHA TOCOPHEROL; ANALYTIC EVALUATION; BONE HEALING; CIPROFLOXACIN; CLODRONATE; COMBINED TREATMENT; HEAD-AND-NECK CANCER; HYPERBARIC OXYGEN; OSTEORADIONECROSIS; PENTOXIFYLLINE; PHASE II; RADIATION-INDUCED; RANDOMIZED TRIAL; VITAMIN-E;

BONE; DERMATITIS; PATIENT REHABILITATION; RADIOTHERAPY;

REFRACTORY MATERIALS;

ALPHA TOCOPHEROL; AMOXICILLIN; CIPROFLOXACIN; CLODRONIC ACID; HEPTAMINOL; OMEPRAZOLE; PENTOXIFYLLINE; PLACEBO; PREDNISONE;

ADULT; AGED; ARTICLE; ASTHENIA; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPIGASTRIC PAIN; EXOSTOSIS; FEMALE; FRACTURE HEALING; HEAD AND NECK CANCER; HUMAN; HYPERBARIC OXYGEN; INSOMNIA; JAW OSTEONECROSIS; MAJOR CLINICAL STUDY; MALE; MANDIBULAR OSTEORADIONECROSIS; NAUSEA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; SKIN FISTULA; TREATMENT DURATION; TREATMENT OUTCOME; VERTIGO;

ADULT; AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; CIPROFLOXACIN; CLODRONIC ACID; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MANDIBULAR DISEASES; MIDDLE AGED; OSTEORADIONECROSIS; PENTOXIFYLLINE; PREDNISONE; PROGNOSIS; TOCOPHEROLS;

EID: 79957578310     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.03.029     Document Type: Article

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