The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 318, Issue 2, 2006, Pages 547-554

  Yang, Ying H ^a,b   Wu, William K K ^b   Tai, Emily K K ^b   Wong, Helen P S ^b   Lam, Emily K Y ^b   So, Wallace H L ^b   Shin, Vivian Y ^b   Cho, Chi H ^b  

^a HAINAN NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CRAMP PEPTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PLASMID VECTOR; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; EPITHELIUM CELL; HOST RESISTANCE; IN VIVO STUDY; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH ULCER; ULCER HEALING;

ACETIC ACID; ACTINS; ANIMALS; ANTI-ULCER AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOTTING, WESTERN; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; EPITHELIAL CELLS; GASTRIC MUCOSA; GENE THERAPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MITOSIS; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STOMACH ULCER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745960395     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.102467     Document Type: Article

References (40)

1. Bowdish DM, Davidson DJ, Speert DP, and Hancock RE (2004) The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. J Immunol 172:3758-3765.
2. Chon JH, Houston MM, Xu C, and Chaikof EL (2001) PR-39 coordinates changes in vascular smooth muscle cell adhesive strength and locomotion by modulating cell surface heparan sulfate-matrix interactions. J Cell Physiol 189:133-143.
3. Ciornei CD, Egesten A, and Bodelsson M (2003) Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro. Acta Anaesthesiol Scand 47:213-220.
4. Davidson DJ, Currie AJ, Reid GS, Bowdish DM, MacDonald KL, Ma RC, Hancock RE, and Speert DP (2004) The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol 172:1146-1156.
5. Dorschner RA, Pestonjamasp VK, Tamakuwala S, Ohtake T, Rudisill J, Nizet V, Agerberth B, Gudmundsson GH, and Gallo RL (2001) Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Investig Dermatol 117:91-97.
6. Elsbach P (2003) What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses? J Clin Investig 111:1643-1645.
7. Elssner A, Duncan M, Gavrilin M, and Wewers MD (2004) A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 172:4987-4994.
8. Gallo RL, Ono M, Povsic T, Page C, Eriksson E, Klagsbrun M, and Bernfield M (1994) Syndecans, cell surface heparan sulfate proteoglycans, are induced by a prolinerich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 91:11035-11039.
9. Hase K, Eckmann L, Leopard JD, Varki N, and Kagnoff MF (2002) Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun 70:953-963.
10. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, and Kagnoff MF (2003) Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 125:1613-1625.
11. Heilborn JD, Nilsson MF, Kratz G, Weber G, Sorensen O, Borregaard N, and Stahle-Backdahl M (2003) The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J Investig Dermatol 120:379-389.
12. Jones MK, Itani RM, Wang H, Tomikawa M, Sarfeh IJ, Szabo S, and Tarnawski AS (1999) Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am J Physiol 276:G1345-G1355.
13. Jones MK, Kawanaka H, Baatar D, Szabo IL, Tsugawa K, Pai R, Koh GY, Kim I, Sarfeh IJ, and Tarnawski AS (2001) Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 121:1040-1047.
14. Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T, Issbrucker K, Unterberger P, Zaiou M, Lebherz C, et al. (2003) An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Investig 111:1665-1672.
15. Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, et al. (2000) PR39, a peptide regulator of angiogenesis. Nat Med 6:49-55.
16. Ma L, Wang WP, Chow JY, Yuen ST, and Cho CH (2000) Reduction of EGF is associated with the delay of ulcer healing by cigarette smoking. Am J Physiol 278:G10-G17.
17. Megraud F (2004) H pylori antibiotic resistance: prevalence, importance and advances in testing. Gut 53:1374-1384.
18. Mookherjee N, Brown KL, Bowdish DM, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, et al. (2006) Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol 176:2455-2464.
19. Naef M, Yokoyama M, Friess H, Buchler MW, and Korc M (1996) Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma. Int J Cancer 66:315-321.
20. Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, and Nagaoka I (2002) A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. Immunology 106:20-26.
21. Pai R, Ohta M, Itani RM, Sarfeh IJ, and Tarnawski AS (1998) Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology 114:706-713.
22. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, and Tarnawski AS (2002) Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8:289-293.
23. Podolsky DK (1999) Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol 277:G495-G499.
24. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, and Blobel CP (2004) Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164:769-779.
25. Schutte BC and McCray PB Jr (2002) β-Defensins in lung host defense. Annu Rev Physiol 64:709-748.
26. Scott MG, Davidson DJ, Gold MR, Bowdish D, and Hancock RE (2002) The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 169:3883-3891.
27. Selsted ME and Ouellette AJ (2005) Mammalian defensins in the antimicrobial immune response. Nat Immunol 6:551-557.
28. Shaykhiev R, Beisswenger C, Kaendler K, Senske J, Puechner A, Damm T, Behr J, and Bals R (2005) The human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol 289:L842-L848.
29. Shin VY, Wu WK, Ye YN, So WH, Koo MW, Liu ES, Luo JC, and Cho CH (2004) Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis 25:2487-2495.
30. Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, and Remaut E (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science (Wash DC) 289:1352-1355.
31. Tanida S, Joh T, Itoh K, Kataoka H, Sasaki M, Ohara H, Nakazawa T, Nomura T, Kinugasa Y, Ohmoto H, et al. (2004) The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells. Gastroenterology 127:559-569.
32. Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, and Gergely H (1992) Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 102:695-698.
33. Tarnawski A, Szabo IL, Husain SS, and Soreghan B (2001) Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol (Paris) 95:337-344.
34. Taupin D and Podolsky DK (2003) Trefoil factors: initiators of mucosal healing. Nat Rev Mol Cell Biol 4:721-732.
35. Termen S, Tollin M, Olsson B, Svenberg T, Agerberth B, and Gudmundsson GH (2003) Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides. Cell Mol Life Sci 60:536-549.
36. Tjabringa GS, Aarbiou J, Ninaber DK, Drijfhout JW, Sorensen OE, Borregaard N, Rabe KF, and Hiemstra PS (2003) The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171:6690-6696.
37. Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, and Tack BF (2000) Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun 68:2748-2755.
38. Xiao ZQ and Majumdar AP (2001) Increased in vitro activation of EGFR by membrane-bound TGF-alpha from gastric and colonic mucosa of aged rats. Am J Physiol 281:G111-G116.
39. Yang D, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, and Chertov O (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, uses formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes and T cells. J Exp Med 192:1069-1074.
40. Zaiou M and Gallo RL (2002) Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med 80:549-561.