Aquaporin-2 regulation in health and disease

Veterinary Clinical Pathology

Volumn 41, Issue 4, 2012, Pages 455-470

  Judith Radin, M ^a   Yu, Ming Jiun ^b,c   Stoedkilde, Lene ^b,d   Lance Miller, R ^b   Hoffert, Jason D ^b   Frokiaer, Jorgen ^d   Pisitkun, Trairak ^b   Knepper, Mark A ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Exosomes; Polyuria; Syndrome of inappropriate antidiuretic hormone excess; Transcription; Vasopressin

Indexed keywords

ANIMALIA;

AQUAPORIN 2; VASOPRESSIN DERIVATIVE;

ANIMAL; GENETICS; HUMAN; KIDNEY COLLECTING TUBULE; METABOLIC DISORDER; METABOLISM; PATHOPHYSIOLOGY; POLYURIA; SIGNAL TRANSDUCTION;

ANIMALS; AQUAPORIN 2; HUMANS; KIDNEY TUBULES, COLLECTING; POLYURIA; SIGNAL TRANSDUCTION; VASOPRESSINS; WATER-ELECTROLYTE IMBALANCE;

EID: 84871171327     PISSN: 02756382     EISSN: 1939165X     Source Type: Journal    
DOI: 10.1111/j.1939-165x.2012.00488.x     Document Type: Review

References (174)

1. DiBartola SP. Hyponatremia. Vet Clin North Am Small Anim Pract. 1998;28:515-532.
2. Nichols R. Polyuria and polydipsia. Diagnostic approach and problems associated with patient evaluation. Vet Clin North Am Small Anim Pract. 2001;31:833-844, v.
3. O'Leary CA, Duffy D, Biros I, Corley S. Linkage confirms canine pkd1 orthologue as a candidate for bull terrier polycystic kidney disease. Anim Genet. 2009;40:543-546.
4. Young AE, Biller DS, Herrgesell EJ, Roberts HR, Lyons LA. Feline polycystic kidney disease is linked to the PKD1 region. Mamm Genome. 2005;16:59-65.
5. Torres VE, Meijer E, Bae KT, et al. Rationale and design of the TEMPO (Tolvaptan efficacy and safety in management of autosomal dominant polycystic kidney disease and its outcomes) 3-4 Study. Am J Kidney Dis. 2011;57:692-699.
6. Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev. 2002;82:205-244.
7. Knepper MA, Wade JB, Terris J, et al. Renal aquaporins [review]. Kidney Int. 1996;49:1712-1717.
8. Nielsen S, Smith BL, Christensen EI, Knepper MA, Agre P. CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol. 1993;120:371-383.
9. Maeda Y, Smith BL, Agre P, Knepper MA. Quantification of aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA. J Clin Invest. 1995;95:422-428.
10. Knepper MA, Valtin H, Sands JM. Renal actions of vasopressin. In: Fray JCS, ed. Handbook of Physiology: The Endocrine System (Section 7). New York, NY: Oxford; 2000:496-529.
11. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature. 1993;361:549-552.
12. Ecelbarger CA, Terris J, Frindt G, et al. Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol Renal Physiol. 1995;269:F663-F672.
13. Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S. Distribution of aquaporin-4 water channel expression within rat kidney. Am J Physiol Renal Physiol. 1995;269:F775-F785.
14. van Vonderen IK, Wolfswinkel J, van den Ingh TS, Mol JA, Rijnberk A, Kooistra HS. Urinary aquaporin-2 excretion in dogs: a marker for collecting duct responsiveness to vasopressin. Domest Anim Endocrinol. 2004;27:141-153.
15. Bauchet AL, Masson R, Guffroy M, Slaoui M. Immunohistochemical identification of kidney nephron segments in the dog, rat, mouse, and cynomolgus monkey. Toxicol Pathol. 2011;39:1115-1128.
16. Brandt LE, Bohn AA, Charles JB, Ehrhart EJ. Localization of canine, feline, and mouse renal membrane proteins. Vet Pathol. 2012;49:693-703.
17. Floyd RV, Mason SL, Proudman CJ, German AJ, Marples D, Mobasheri A. Expression and nephron segment-specific distribution of major renal aquaporins (AQP1-4) in Equus caballus, the domestic horse. Am J Physiol Regul Integr Comp Physiol. 2007;293:R492-R503.
18. Gobet R, Norregaard R, Cisek LJ, Peters CA, Nielsen S, Frokiaer J. Experimental congenital vesicoureteral reflux in sheep is associated with reduced renal expression levels of aquaporin 1 and 2. J Urol. 2008;179:2396-2401.
19. Suzuki M, Endo N, Nakano Y, Kato H, Kishiro T, Asahina K. Localization of aquaporin-2, renal morphology and urine composition in the bottlenose dolphin and the Baird's beaked whale. J Comp Physiol B. 2008;178:149-156.
20. Lau KK, Yang Y, Cook GA, Wyatt RJ, Nishimura H. Control of aquaporin 2 expression in collecting ducts of quail kidneys. Gen Comp Endocrinol. 2009;160:288-294.
21. Yang Y, Cui Y, Wang W, et al. Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney. Am J Physiol Regul Integr Comp Physiol. 2004;287:R915-R924.
22. Nishimura H. Urine concentration and avian aquaporin water channels. Pflugers Arch. 2008;456:755-768.
23. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA. Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci USA. 1995;92:1013-1017.
24. Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW. Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA. 1993;90:11663-11667.
25. 2} receptor in rat kidney. J Clin Invest. 1994;94:1778-1783.
26. DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci USA. 1994;91:8984-8988.
27. Saito T, Ishikawa S, Sasaki S, et al. Lack of vasopressin-independent upregulation of AQP-2 gene expression in homozygous Brattleboro rats. Am J Physiol. 1999;277:R427-R433.
28. Kishore BK, Terris JM, Knepper MA. Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP. Am J Physiol. 1996;271:F62-F70.
29. Nedvetsky PI, Tabor V, Tamma G, et al. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010;21:1645-1656.
30. Pisitkun T, Jacob V, Schleicher SM, Chou CL, Yu MJ, Knepper MA. Akt and ERK1/2 pathways are components of the vasopressin signaling network in rat native IMCD. Am J Physiol Renal Physiol. 2008;295:F1030-F1043.
31. Yu MJ, Miller RL, Uawithya P, et al. Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. Proc Natl Acad Sci USA. 2009;106:2441-2446.
32. Kanno K, Sasaki S, Hirata Y, et al. Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N Engl J Med. 1995;332:1540-1545.
33. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004;101:13368-13373.
34. Pisitkun T, Johnstone R, Knepper MA. Discovery of urinary biomarkers. Mol Cell Proteomics. 2006;5:1760-1771.
35. Gonzales PA, Pisitkun T, Hoffert JD, et al. Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol. 2009;20:363-379.
36. Elliot S, Goldsmith P, Knepper M, Haughey M, Olson B. Urinary excretion of aquaporin-2 in humans: a potential marker of collecting duct reponsiveness to vasopressin. J Am Soc Nephrol. 1996;7:403-409.
37. Deen PM, van Aubel RA, van Lieburg AF, van Os CH. Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. J Am Soc Nephrol. 1996;7:836-841.
38. Saito T, Ishikawa SE, Sasaki S, et al. Urinary excretion of aquaporin-2 in the diagnosis of central diabetes insipidus. J Clin Endocrinol Metab. 1997;82:1823-1827.
39. Rai T, Sekine K, Kanno K, et al. Urinary excretion of aquaporin-2 water channel protein in human and rat. J Am Soc Nephrol. 1997;8:1357-1362.
40. van Vonderen IK, Kooistra HS, Timmermans-Sprang EP, Meij BP, Rijnberk A. Vasopressin response to osmotic stimulation in 18 young dogs with polyuria and polydipsia. J Vet Intern Med. 2004;18:800-806.
41. Kamsteeg EJ, Hendriks G, Boone M, et al. Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc Natl Acad Sci USA. 2006;103:18344-18349.
42. Sandoval P, Slentz D, Pisitkun T, et al. LC-MS/MS-based large-scale profiling of protein half lives in renal collecting duct cells reveals that vasopressin increases half-life of aquaporin-2 protein [abstract]. FASEB J. 2011;25:1039.
43. Kitamura M. Endoplasmic reticulum stress in the kidney. Clin Exp Nephrol. 2008;12:317-325.
44. Hayashi M, Sasaki S, Tsuganezawa H, et al. Role of vasopressin V2 receptor in acute regulation of aquaporin-2. Kidney Blood Press Res. 1996;19:32-37.
45. Ecelbarger CA, Nielsen S, Olson BR, et al. Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat. J Clin Invest. 1997;99:1852-1863.
46. Khositseth S, Pisitkun T, Slentz DH, et al. Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells. Mol Cell Proteomics. 2011;10:M110.
47. Parker R, Sheth U. P bodies and the control of mRNA translation and degradation. Mol Cell. 2007;25:635-646.
48. Liu J. Control of protein synthesis and mRNA degradation by microRNAs. Curr Opin Cell Biol. 2008;20:214-221.
49. Uchida S, Sasaki S, Fushimi K, Marumo F. Isolation of human aquaporin-CD gene. J Biol Chem. 1994;269:23451-234515.
50. Rai T, Uchida S, Marumo F, Sasaki S. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol. 1997;273:F264-F273.
51. Tchapyjnikov D, Li Y, Pisitkun T, Hoffert JD, Yu MJ, Knepper MA. Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS. Physiol Genomics. 2010;40:167-183.
52. Schenk LK, Bolger SJ, Luginbuhl K, et al. Quantitative proteomics identifies vasopressin-responsive nuclear proteins in collecting duct cells. J Am Soc Nephrol. 2012;23:1008-1018.
53. Hozawa S, Holtzman EJ, Ausiello DA. cAMP motifs regulating transcription in the aquaporin-2 gene. Am J Physiol. 1996;270:C1695-C1702.
54. Matsumura Y, Uchida S, Rai T, Sasaki S, Marumo F. Transcriptional regulation of aquaporin-2 water channel gene by cAMP. J Am Soc Nephrol. 1997;8:861-867.
55. Yasui M, Zelenin SM, Celsi G, Aperia A. Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol Renal Physiol. 1997;272:F443-F450.
56. Furuno M, Uchida S, Marumo F, Sasaki S. Repressive regulation of the aquaporin-2 gene. Am J Physiol. 1996;271:F854-F860.
57. Uchida S, Matsumura Y, Rai T, Sasaki S, Marumo F. Regulation of aquaporin-2 gene transcription by GATA-3. Biochem Biophys Res Commun. 1997;232:65-68.
58. Hasler U, Jeon US, Kim JA, et al. Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells. J Am Soc Nephrol. 2006;17:1521-1531.
59. Li SZ, McDill BW, Kovach PA, et al. Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress. Am J Physiol Cell Physiol. 2007;292:C1606-C1616.
60. Terris J, Ecelbarger CA, Nielsen S, Knepper MA. Long-term regulation of four renal aquaporins in rat. Am J Physiol. 1996;271:F414-F422.
61. Cha JH, Woo SK, Han KH, et al. Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney. J Am Soc Nephrol. 2001;12:2221-2230.
62. Hoffert JD, Chou CL, Fenton RA, Knepper MA. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. J Biol Chem. 2005;280:13624-13630.
63. Nielsen S, Knepper MA. Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes. Am J Physiol. 1993;265:F204-F213.
64. Wall SM, Han JS, Chou CL, Knepper MA. Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD. Am J Physiol. 1992;262:F989-F998.
65. Star RA, Nonoguchi H, Balaban R, Knepper MA. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest. 1988;81:1879-1888.
66. 2+ mobilization and apical exocytosis in perfused rat kidney collecting duct. J Physiol. 2002;538:891-899.
67. Chou CL, Christensen BM, Frische S, et al. Non-muscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct. J Biol Chem. 2004;279:49026-49035.
68. Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci USA. 2006;103:7159-7164.
69. Rinschen MM, Yu MJ, Wang G, et al. Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci USA. 2010;107:3882-3887.
70. Bansal AD, Hoffert JD, Pisitkun T, et al. Phosphoproteomic profiling reveals vasopressin-regulated phosphorylation sites in collecting duct. J Am Soc Nephrol. 2010;21:303-315.
71. Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA. Transcriptional profiling of native inner medullary collecting duct cells from rat kidney. Physiol Genomics. 2008;32:229-253.
72. Torres VE, Bankir L, Grantham JJ. A case for water in the treatment of polycystic kidney disease. Clin J Am Soc Nephrol. 2009;4:1140-1150.
73. O'Leary CA, Mackay BM, Malik R, Edmondston JE, Robinson WF, Huxtable CR. Polycystic kidney disease in bull terriers: an autosomal dominant inherited disorder. Aust Vet J. 1999;77:361-366.
74. Eaton KA, Biller DS, DiBartola SP, Radin MJ, Wellman ML. Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats. Vet Pathol. 1997;34:117-126.
75. Mutig K, Paliege A, Kahl T, Jons T, Muller-Esterl W, Bachmann S. Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL. Am J Physiol Renal Physiol. 2007;293:F1166-F1177.
76. Gattone VH, Wang X, Harris PC, Torres VE. Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med. 2003;9:1323-1326.
77. Yamaguchi T, Nagao S, Wallace DP, et al. Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int. 2003;63:1983-1994.
78. Torres VE. Vasopressin antagonists in polycystic kidney disease. Semin Nephrol. 2008;28:306-317.
79. Schrier RW, Ohara M, Rogachev B, Xu L, Knotek M. Aquaporin-2 water channels and vasopressin antagonists in edematous disorders. Mol Genet Metab. 1998;65:255-263.
80. Rossi TA, Ross LA. Diabetes insipidus. Compend Contin Educ Vet. 2008;30:43-52.
81. Schott HC. Water homeostasis and diabetes insipidus in horses. Vet Clin North Am Equine Pract. 2011;27:175-195.
82. Harb MF, Nelson RW, Feldman EC, Scott-Moncrieff JC, Griffey SM. Central diabetes insipidus in dogs: 20 cases (1986-1995). J Am Vet Med Assoc. 1996;209:1884-1888.
83. Authement JM, Boudrieau RJ, Kaplan PM. Transient, traumatically induced, central diabetes insipidus in a dog. J Am Vet Med Assoc. 1989;194:683-685.
84. Foley C, Bracker K, Drellich S. Hypothalamic-pituitary axis deficiency following traumatic brain injury in a dog. J Vet Emerg Crit Care (San Antonio). 2009;19:269-274.
85. Ferguson DC, Biery DN. Diabetes insipidus and hyperadrenocorticism associated with high plasma adrenocorticotropin concentration and a hypothalamic/pituitary mass in a dog. J Am Vet Med Assoc. 1988;193:835-839.
86. Goossens MM, Rijnberk A, Mol JA, Wolfswinkel J, Voorhout G. Central diabetes insipidus in a dog with a pro-opiomelanocortin-producing pituitary tumor not causing hyperadrenocorticism. J Vet Intern Med. 1995;9:361-365.
87. Hanson JM, van't HM, Voorhout G, Teske E, Kooistra HS, Meij BP. Efficacy of transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med. 2005;19:687-694.
88. Teshima T, Hara Y, Taoda T, Teramoto A, Tagawa M. Central diabetes insipidus after transsphenoidal surgery in dogs with Cushing's disease. J Vet Med Sci. 2011;73:33-39.
89. Neer TM, Reavis DU. Craniopharyngioma and associated central diabetes insipidus and hypothyroidism in a dog. J Am Vet Med Assoc. 1983;182:519-520.
90. Nielsen L, Thompson H, Hammond GJ, Chang YP, Ramsey IK. Central diabetes insipidus associated with primary focal B cell lymphoma in a dog. Vet Rec. 2008;162:124-126.
91. Davenport DJ, Chew DJ, Johnson GC. Diabetes insipidus associated with metastatic pancreatic carcinoma in a dog. J Am Vet Med Assoc. 1986;189:204-205.
92. Post K, McNeill JR, Clark EG, Dignean MA, Olynyk GP. Congenital central diabetes insipidus in two sibling Afghan hound pups. J Am Vet Med Assoc. 1989;194:1086-1088.
93. Campbell FE, Bredhauer B. Trauma-induced central diabetes insipidus in a cat. Aust Vet J. 2008;86:102-105.
94. Aroch I, Mazaki-Tovi M, Shemesh O, Sarfaty H, Segev G. Central diabetes insipidus in five cats: clinical presentation, diagnosis and oral desmopressin therapy. J Feline Med Surg. 2005;7:333-339.
95. Smith JR, Elwood CM. Traumatic partial hypopituitarism in a cat. J Small Anim Pract. 2004;45:405-409.
96. Rogers WA, Valdez H, Anderson BC, Comella C. Partial deficiency of antidiuretic hormone in a cat. J Am Vet Med Assoc. 1977;170:545-547.
97. Burnie AG, Dunn JK. A case of central diabetes insipidus in the cat: diagnosis and treatment. J Small Anim Pract. 1982;23:237-241.
98. Court MH, Watson AD. Idiopathic neurogenic diabetes insipidus in a cat. Aust Vet J. 1983;60:245-247.
99. Green RA, Farrow CS. Diabetes insipidus in a cat. J Am Vet Med Assoc. 1974;164:524-526.
100. Pittari JM. Central diabetes insipidus in a cat. Feline Pract. 2012;24:18-21.
101. Winterbotham J, Mason KV. Congenital diabetes insipidus in a kitten. J Small Anim Pract. 1983;24:569-573.
102. Simpson CJ, Mansfield CS, Milne ME, Hodge PJ. Central diabetes insipidus in a cat with central nervous system B cell lymphoma. J Feline Med Surg. 2011;13:787-792.
103. Breukink HJ, Van WP, Schotman AJ. Idiopathic diabetes insipidus in a Welsh pony. Equine Vet J. 1983;15:284-287.
104. Filar J, Ziolo T, Szalecki J. Diabetes insipidus in the course of encephalitis in the horse. Med Weter. 1971;27:205-207.
105. McFarlane D. Equine pituitary pars intermedia dysfunction. Vet Clin North Am Equine Pract. 2011;27:93-113.
106. Kranenburg LC, Thelen MH, Westermann CM, de Graaf-Roelfsema E, van der Kolk JH. Use of desmopressin eye drops in the treatment of equine congenital central diabetes insipidus. Vet Rec. 2010;167:790-791.
107. Braun U, Feller B, Gerber A, Ossent P. [Diabetes insipidus in a Swiss Braunvieh heifer with internal hydrocephalus]. Schweiz Arch Tierheilkd. 2008;150:409-412.
108. Wallace CE, Kociba GJ. Diabetes insipidus in a cow. J Am Vet Med Assoc. 1979;175:809-811.
109. Thomson JR, Anderson DH, Gilmour JS. Neurogenic diabetes insipidus in a sheep. J Comp Pathol. 1986;96:119-124.
110. Houpt KA. Feeding and drinking behavior problems. Vet Clin North Am Small Anim Pract. 1991;21:281-298.
111. Mulnix JA, Rijnberk A, Hendriks HJ. Evaluation of a modified water-deprivation test for diagnosis of polyuric disorders in dogs. J Am Vet Med Assoc. 1976;169:1327-1330.
112. van Vonderen I, Kooistra HS, Sprang EP, Rijnberk A. Disturbed vasopressin release in 4 dogs with so-called primary polydipsia. J Vet Intern Med. 1999;13:419-425.
113. Grauer GF, Pitts RP. Primary polydipsia in three dogs with portosystemic shunts. J Am Anim Hosp Assoc. 1987;23:197-200.
114. Henderson SM, Elwood CM. A potential causal association between gastrointestinal disease and primary polydipsia in three dogs. J Small Anim Pract. 2003;44:280-284.
115. McKenzie EC. Polyuria and polydipsia in horses. Vet Clin North Am Equine Pract. 2007;23:641-653, vii.
116. Browning AP. Polydipsia and polyuria in two horses caused by psychogenic polydipsia. Equine Vet Educ. 2000;12:175-178.
117. Buntain BJ, Coffman JR. Polyuria and polydypsia in a horse induced by psychogenic salt consumption. Equine Vet J. 1981;13:266-268.
118. Suttle N. Sodium and chloride. In: Mineral Nutrition of Livestock. 4th ed. Wallingford, UK: CABI; 2010:182-205.
119. Valtin H. "Drink at least eight glasses of water a day." Really? Is there scientific evidence for "8 x 8"? Am J Physiol Regul Integr Comp Physiol. 2002;283:R993-R1004.
120. De Wardener HE, Herxheimer A. The effect of a high water intake on the kidney's ability to concentrate the urine in man. J Physiol. 1957;139:42-52.
121. Harbaugh C, Knepper MA. Do you have a drinking problem? Running Times. 2007;9:14-17.
122. Bichet DG. Hereditary polyuric disorders: new concepts and differential diagnosis 6. Semin Nephrol. 2006;26:224-233.
123. Luzius H, Jans DA, Grunbaum EG, Moritz A, Rascher W, Fahrenholz F. A low affinity vasopressin V2-receptor in inherited nephrogenic diabetes insipidus. J Recept Res. 1992;12:351-368.
124. Schott HC, Bayly WM, Reed SM, Brobst DF. Nephrogenic diabetes insipidus in sibling colts. J Vet Intern Med. 1993;7:68-72.
125. Deen PM, Marr N, Kamsteeg EJ, van Balkom BW. Nephrogenic diabetes insipidus. Curr Opin Nephrol Hypertens. 2000;9:591-595.
126. Brummermann M, Braun EJ. Renal response of roosters with diabetes insipidus to infusions of arginine vasotocin. Am J Physiol. 1995;269:R57-R63.
127. Minvielle F, Grossmann R, Gourichon D. Development and performances of a Japanese quail line homozygous for the diabetes insipidus (di) mutation. Poult Sci. 2007;86:249-254.
128. Marples D, Christensen S, Christensen EI, Ottosen PD, Nielsen S. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest. 1995;95:1838-1845.
129. Frokiaer J, Marples D, Knepper MA, Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol. 1996;270:F657-F668.
130. Marples D, Frokiaer J, Dorup J, Knepper MA, Nielsen S. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest. 1996;97:1960-1968.
131. Frokiaer J, Christensen BM, Marples D, et al. Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction. Am J Physiol. 1997;273:F213-F223.
132. Li C, Wang W, Kwon TH, et al. Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect. Am J Physiol Renal Physiol. 2001;281:F163-F171.
133. Li C, Wang W, Knepper MA, Nielsen S, Frokiaer J. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2003;284:F1066-F1079.
134. Kim SW, Cho SH, Oh BS, et al. Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. J Am Soc Nephrol. 2001;12:2019-2028.
135. Jensen AM, Li C, Praetorius HA, et al. Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction. Am J Physiol Renal Physiol. 2006;291:F1021-F1032.
136. Norregaard R, Jensen BL, Li C, et al. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol. 2005;289:F322-F333.
137. Norregaard R, Jensen BL, Topcu SO, et al. COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction. Am J Physiol Renal Physiol. 2007;292:F1322-F1333.
138. Stone KA. Lithium-induced nephrogenic diabetes insipidus. J Am Board Fam Pract. 1999;12:43-47.
139. Abrams-Ogg AC. The use of lithium carbonate to prevent lomustine-induced myelosuppression in dogs: a pilot study. Can J Vet Res. 2011;75:73-76.
140. Davies NL. Lithium toxicity in two dogs. J S Afr Vet Assoc. 1991;62:140-142.
141. Wen H, Frokiaer J, Kwon TH, Nielsen S. Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway. J Am Soc Nephrol. 1999;10:1416-1429.
142. Laursen UH, Pihakaski-Maunsbach K, Kwon TH, Ostergaard JE, Nielsen S, Maunsbach AB. Changes of rat kidney AQP2 and Na, K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus. Nephron Exp Nephrol. 2004;97:e1-e16.
143. Christensen S, Kusano E, Yusufi AN, Murayama N, Dousa TP. Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats. J Clin Invest. 1985;75:1869-1879.
144. Li Y, Shaw S, Kamsteeg EJ, Vandewalle A, Deen PM. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. J Am Soc Nephrol. 2006;17:1063-1072.
145. Sands JM, Naruse M, Baum M, et al. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest. 1997;99:1399-1405.
146. Bustamante M, Hasler U, Leroy V, et al. Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism. J Am Soc Nephrol. 2008;19:109-116.
147. Rao R, Patel S, Hao C, Woodgett J, Harris R. GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. J Am Soc Nephrol. 2010;21:428-437.
148. Nielsen J, Hoffert JD, Knepper MA, Agre P, Nielsen S, Fenton RA. Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Proc Natl Acad Sci USA. 2008;105:3634-3639.
149. Berl T, Linas SL, Aisenbrey GA, Anderson RJ. On the mechanism of polyuria in potassium depletion. The role of polydipsia. J Clin Invest. 1977;60:620-625.
150. Hollander W Jr, Winters RW, Williams TF, Bradley J, Oliver J, Welt LG. Defect in the renal tubular reabsorption of water associated with potassium depletion in rats. Am J Physiol. 1957;189:557-563.
151. Manitius A, Levitin H, Beck D, Epstein FH. On the mechanism of impairment of renal concentrating ability in potassium deficiency. J Clin Invest. 1960;39:684-692.
152. Rutecki GW, Cox JW, Robertson GW, Francisco LL, Ferris TF. Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium-depleted dog. J Lab Clin Med. 1982;100:53-60.
153. Marples D, Frokiaer J, Dorup J, Knepper MA, Nielsen S. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest. 1996;97:1960-1968.
154. Amlal H, Krane CM, Chen Q, Soleimani M. Early polyuria and urinary concentrating defect in potassium deprivation. Am J Physiol Renal Physiol. 2000;279:F655-F663.
155. Pretzer SD. Clinical presentation of canine pyometra and mucometra: a review. Theriogenology. 2008;70:359-363.
156. Kenney KJ, Matthiesen DT, Brown NO, Bradley RL. Pyometra in cats: 183 cases (1979-1984). J Am Vet Med Assoc. 1987;191:1130-1132.
157. Heiene R, van Vonderen IK, Moe L, Molmen GS, Larsen NH, Kooistra HS. Vasopressin secretion in response to osmotic stimulation and effects of desmopressin on urinary concentrating capacity in dogs with pyometra. Am J Vet Res. 2004;65:404-408.
158. Scheim A. Renal function in dogs with pyometra. 2. Concentrating and diluting ability. Acta Vet Scand. 1963;4:293-306.
159. Maddens B, Heiene R, Smets P, et al. Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers. J Vet Intern Med. 2011;25:1075-1083.
160. Grinevich V, Knepper MA, Verbalis J, Reyes I, Aguilera G. Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla. Kidney Int. 2004;65:54-62.
161. Hasler U, Leroy V, Jeon US, et al. NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. J Biol Chem. 2008;283:28095-28105.
162. Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010;298:F196-F204.
163. Stone EA, Littman MP, Robertson JL, Bovee KC. Renal dysfunction in dogs with pyometra. J Am Vet Med Assoc. 1988;193:457-464.
164. Shiel RE, Pinilla M, Mooney CT. Syndrome of inappropriate antidiuretic hormone secretion associated with congenital hydrocephalus in a dog. J Am Anim Hosp Assoc. 2009;45:249-252.
165. Brofman PJ, Knostman KA, DiBartola SP. Granulomatous amebic meningoencephalitis causing the syndrome of inappropriate secretion of antidiuretic hormone in a dog. J Vet Intern Med. 2003;17:230-234.
166. Breitschwerdt EB, Root CR. Inappropriate secretion of antidiuretic hormone in a dog. J Am Vet Med Assoc. 1979;175:181-186.
167. Houston DM, Allen DG, Kruth SA, Pook H, Spinato MT, Keough L. Syndrome of inappropriate antidiuretic hormone secretion in a dog. Can Vet J. 1989;30:423-425.
168. Rijnberk A, Biewenga WJ, Mol JA. Inappropriate vasopressin secretion in two dogs. Acta Endocrinol (Copenh). 1988;117:59-64.
169. Fleeman LM, Irwin PJ, Phillips PA, West J. Effects of an oral vasopressin receptor antagonist (OPC-31260) in a dog with syndrome of inappropriate secretion of antidiuretic hormone. Aust Vet J. 2000;78:825-830.
170. Cameron K, Gallagher A. Syndrome of inappropriate antidiuretic hormone secretion in a cat. J Am Anim Hosp Assoc. 2010;46:425-432.
171. Grant IA, Karnik K, Jandrey KE. Toxicities and salvage therapy following overdose of vinblastine in a cat. J Small Anim Pract. 2010;51:127-131.
172. Fujita N, Ishikawa SE, Sasaki S, et al. Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats. Am J Physiol. 1995;269:F926-F931.
173. Saito T, Higashiyama M, Nagasaka S, Sasaki S, Saito T, Ishikawa SE. Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis. Kidney Int. 2001;60:1266-1276.
174. Ecelbarger CA, Chou CL, Lee AJ, DiGiovanni SR, Verbalis JG, Knepper MA. Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct. Am J Physiol. 1998;274:F1161-F1166.