Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 5, 2006, Pages

  Jensen, Anja M ^a   Li, Chunling ^a   Praetorius, Helle A ^a   Nørregaard, Rikke ^a   Frische, Sebastian ^a   Knepper, Mark A ^b   Nielsen, Søren ^a   Frøkiær, Jørgen ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

Author keywords

Angiotensin; Aquaporins; AT1 receptor blockade

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; AQUAPORIN; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; BUMETANIDE; CANDESARTAN; CYCLOOXYGENASE 2; SODIUM; SODIUM PHOSPHATE COTRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER 2; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; ANGIOTENSIN RECEPTOR ANTAGONIST; AQP1 PROTEIN, RAT; AQP2 PROTEIN, RAT; AQP3 PROTEIN, RAT; BENZIMIDAZOLE DERIVATIVE; PHOSPHATE; PTGS2 PROTEIN, RAT; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN; SODIUM-POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN; TETRAZOLE DERIVATIVE; VASOCONSTRICTOR AGENT;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DOWN REGULATION; IMMUNOCYTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY TUBULE FUNCTION; MALE; NONHUMAN; PATHOPHYSIOLOGY; POLYURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM ABSORPTION; SODIUM TRANSPORT; SODIUM URINE LEVEL; URETER OBSTRUCTION; URINARY TRACT OBSTRUCTION; URINE OSMOLALITY; URINE VOLUME; ANIMAL; DRUG EFFECT; GLOMERULUS FILTRATION RATE; METABOLISM; PHYSIOLOGY; URINE; WISTAR RAT;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; AQUAPORINS; BENZIMIDAZOLES; CYCLOOXYGENASE 2; DOWN-REGULATION; GLOMERULAR FILTRATION RATE; MALE; PHOSPHATES; POLYURIA; RATS; RATS, WISTAR; SODIUM; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE II; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; TETRAZOLES; URETERAL OBSTRUCTION; VASOCONSTRICTOR AGENTS;

EID: 33750930843     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00387.2005     Document Type: Article

References (59)

1. - cotransport via 20-HETE and PKC in medullary thick ascending limb. Am J Physiol Cell Physiol 274: C1047-C1056, 1998.
2. Beutler KT, Masilamani S, Turban S, Nielsen J, Brooks HL, Ageloff S, Fenton RA, Packer RK, and Knepper MA. Long-term regulation of ENaC expression in kidney by angiotensin II. Hypertension 41: 1143-1150, 2003.
3. Braam B, Mitchell KD, Fox J, and Navar LG. Proximal tubular secretion of angiotensin II in rats. Am J Physiol Renal Fluid Electrolyte Physiol 264: F891-F898, 1993.
4. Breyer MD and Breyer RM. Prostaglandin receptors: their role in regulating renal function. Curr Opin Nephrol Hypertens 9: 23-29, 2000.
5. Chatelain D, Montel V, Dickes-Coopman A, Chatelain A, and Deloof S. Trophic and steroidogenic effects of water deprivation on the adrenal gland of the adult female rat. Regul Pept 110: 249-255, 2003.
6. Cheng X, Zhang H, Lee HL, and Park JM. Cyclooxygenase-2 inhibitor preserves medullary aquaporin-2 expression and prevents polyuria after ureteral obstruction. J Urol 172: 2387-2390, 2004.
7. 2-receptor agonist/antagonist treatment. Am J Physiol Renal Physiol 278: F29-F42, 2000.
8. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, and Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279: F46-F53, 2000.
9. - cotransporter, BSC-1. Am J Physiol Renal Fluid Electrolyte Physiol 271: F619-F628, 1996.
10. 1). J Pharmacol Exp Ther 266: 506-510, 1993.
11. El Dahr SS, Gee J, Dipp S, Hanss BG, Vari RC, and Chao J. Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy. Am J Physiol Renal Fluid Electrolyte Physiol 264: F874-F881, 1993.
12. + transporters. Kidney Int 54: 170-179, 1998.
13. Frøkiær J, Djurhuus JC, Nielsen M, and Pedersen EB. Renal hemodynamic response to ureteral obstruction during converting enzyme inhibition. Urol Res 24: 217-227, 1996.
14. Frøkiær J, Knudsen L, Nielsen AS, Pedersen EB, and Djurhuus JC. Enhanced intrarenal angiotensin II generation in response to obstruction of the pig ureter. Am J Physiol Renal Fluid Electrolyte Physiol 263: F527-F533, 1992.
15. Frøkiær J, Marples D, Knepper MA, and Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 270: F657-F668, 1996.
16. Gimenez I and Forbush B. Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem 278: 26946-26951, 2003.
17. Harris RC, Meyer TW, and Brenner BM. Nephron adaption to renal injury. In: The Kidney. Philadelphia, PA: Ardmore Medical Books, 1986.
18. Harris PJ and Young JA. Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflügers Arch 367: 295-297, 1977.
19. Harris RC. Cyclooxygenase-2 in the kidney. J Am Soc Nephrol 11: 2387-2394, 2000.
20. Hwang SJ, Haas M, Harris HW Jr, Silva P, Yalla S, Sullivan MR, Otuechere G, Kashgarian M, and Zeidel ML. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. J Clin Invest 91: 21-28, 1993.
21. Hwang SJ, Harris HW Jr Otuechere G, Yalla S, Sullivan MR, Kashgarian M, Benos DJ, Kleyman TR, and Zeidel ML. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. Am J Physiol Renal Fluid Electrolyte Physiol 264: F808-F815, 1993.
22. Ishidoya S, Morrissey J, McCracken R, Reyes A, and Klahr S. Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction. Kidney Int 47: 1285-1294, 1995.
23. Ivarsen P, Frøkiær J, Aagaard NK, Hansen EF, Bendtsen F, Nielsen S, and Vilstrup H. Increased urinary excretion of aquaporin 2 in patients with liver cirrhosis. Gut 52: 1194-1199, 2003.
24. Kaneto H, Morrissey J, McCracken R, Reyes A, and Klahr S. Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney. Kidney Int 45: 1637-1647, 1994.
25. Kashgarian M, Biemesderfer D, Caplan M, and Forbush B III. Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments. Kidney Int 28: 899-913, 1985.
26. Kim GH, Ecelbarger C, Knepper MA, and Packer RK. Regulation of thick ascending limb ion transporter abundance in response to altered acid/base intake. J Am Soc Nephrol 10: 935-942, 1999.
27. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, and Knepper MA. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 276: F96-F103, 1999.
28. Kim GH, Martin SW, Fernandez-Llama P, Masilamani S, Packer RK, and Knepper MA. Long-term regulation of renal Na-dependent cotransporters and ENaC: response to altered acid-base intake. Am J Physiol Renal Physiol 279: F459-F467, 2000.
29. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, and Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
30. Kim SW, Cho SH, Oh BS, Yeum CH, Choi KC, Ahn KY, and Lee J. Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. J Am Soc Nephrol 12: 2019-2028, 2001.
31. Klahr S and Morrissey J. Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 283: F861-F875, 2002.
32. Knepper MA, Kim GH, Fernandez-Llama P, and Ecelbarger CA. Regulation of thick ascending limb transport by vasopressin. J Am Soc Nephrol 10: 628-634, 1999.
33. Knepper MA, Nielsen S, Chou CL, and DiGiovanni SR. Mechanism of vasopressin action in the renal collecting duct. Semin Nephrol 14: 302-321, 1994.
34. Kwon TH, Frøkiær J, Fernandez-Llama P, Knepper MA, and Nielsen S. Reduced abundance of aquaporins in rats with bilateral ischemiainduced acute renal failure: prevention by α-MSH. Am J Physiol Renal Physiol 277: F413-F427, 1999.
35. Kwon TH, Nielsen J, Kim YH, Knepper MA, Frøkiær J, and Nielsen S. Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II. Am J Physiol Renal Physiol 285: F152-F165, 2003.
36. 1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Am J Physiol Renal Physiol 288: F673-F684, 2005.
37. Li C, Klein JD, Wang W, Knepper MA, Nielsen S, Sands JM, and Frøkiær J. Altered expression of urea transporters in response to ureteral obstruction. Am J Physiol Renal Physiol 286: F1154-F1162, 2004.
38. Li C, Wang W, Kwon TH, Isikay L, Wen JG, Marples D, Djurhuus JC, Stockwell A, Knepper MA, Nielsen S, and Frøkiær J. Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect. Am J Physiol Renal Physiol 281: F163-F171, 2001.
39. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, and Frøkiær J. Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction. Am J Physiol Renal Physiol 284: F155-F166, 2003.
40. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, and Frøkiær J. Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction. Am J Physiol Renal Physiol 285: F889-F901, 2003.
41. Manucha W, Oliveros L, Carrizo L, Seltzer A, and Valles P. Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction. Kidney Int 65: 2091-2107, 2004.
42. Marples D, Knepper MA, Christensen EI, and Nielsen S. Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am J Physiol Cell Physiol 269: C655-C664, 1995.
43. Murer H, Werner A, Reshkin S, Wuarin F, and Biber J. Cellular mechanisms in proximal tubular reabsorption of inorganic phosphate. Am J Physiol Cell Physiol 260: C885-C899, 1991.
44. Nadler SP, Zimpelmann JA, and Hebert RL. PGE2 inhibits water permeability at a post-cAMP site in rat terminal inner medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 262: F229-F235, 1992.
45. Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, and Harris HW. Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA 90: 11663-11667, 1993.
46. Nishimoto G, Zelenina M, Li D, Yasui M, Aperia A, Nielsen S, and Nairn AC. Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue. Am J Physiol Renal Physiol 276: F254-F259, 1999.
47. Norregaard R, Jensen BL, Li C, Wang W, Knepper MA, Nielsen S, and Frøkiær J. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol 289: F322-F333, 2005.
48. Purkerson ML, Blaine EH, Stokes TJ, and Klahr S. Role of atrial peptide in the natriuresis and diuresis that follows relief of obstruction in rat. Am J Physiol Renal Fluid Electrolyte Physiol 256: F583-F589, 1989.
49. Purkerson ML and Klahr S. Prior inhibition of vasoconstrictors normalizes GFR in postobstructed kidneys. Kidney Int 35: 1305-1314, 1989.
50. Purkerson ML, Rolf DB, Chase LR, Slatopolsky E, and Klahr S. Tubular reabsorption of phosphate after release of complete ureteral obstruction in the rat. Kidney Int 5: 326-336, 1974.
51. Reams G, Villarreal D, Wu Z, and Bauer JH. Renal tissue angiotensin II: response to infusions of angiotensin I and an angiotensin-converting enzyme inhibitor. Am J Kidney Dis 22: 851-857, 1993.
52. Schuster VL, Kokko JP, and Jacobson HR. Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules. J Clin Invest 73: 507-515, 1984.
53. Smart ML, Hiranyachattada S, and Harris PJ. Effects of angiotensin II receptor blockade on proximal fluid uptake in the rat kidney. Br J Pharmacol 126: 697-700, 1999.
54. Star RA, Nonoguchi H, Balaban R, and Knepper MA. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest 81: 1879-1888, 1988.
55. Terris J, Ecelbarger CA, Nielsen S, and Knepper MA. Long-term regulation of four renal aquaporins in rats. Am J Physiol Renal Fluid Electrolyte Physiol 271: F414-F422, 1996.
56. Torikai S and Imai M. Effects of solute concentration on vasopressin stimulated cyclic AMP generation in the rat medullary thick ascending limbs of Henle's loop. Pflügers Arch 400: 306-308, 1984.
57. 1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan. Am J Physiol Renal Physiol 287: F474-F480, 2004.
58. Yarger WE, Schocken DD, and Harris RH. Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function. J Clin Invest 65: 400-412, 1980.
59. Zeidel ML. Low permeabilities of apical membranes of barrier epithelia: what makes watertight membranes watertight? Am J Physiol Renal Fluid Electrolyte Physiol 271: F243-F245, 1996.