Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 9, 2008, Pages 3634-3639

  Nielsen, Jakob ^a   Hoffert, Jason D ^b   Knepper, Mark A ^b   Agre, Peter ^c   Nielsen, Søren ^a   Fenton, Robert A ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Akt kinase; Differential gel electrophoresis (DIGE); GSK3 ; Kidney

Indexed keywords

AQUAPORIN 2; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3ALPHA; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; LITHIUM; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOINFORMATICS; BIPOLAR DISORDER; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES INSIPIDUS; DOWN REGULATION; ENZYME PHOSPHORYLATION; GEL ELECTROPHORESIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; RAT; RENAL DIABETES; SIGNAL TRANSDUCTION; VALIDATION STUDY; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; GENETICS; IN VITRO STUDY; KIDNEY COLLECTING TUBULE; METHODOLOGY; NEPHROGENIC DIABETES INSIPIDUS;

RATTUS;

ANIMALS; AQUAPORIN 2; CELL PROLIFERATION; DIABETES INSIPIDUS, NEPHROGENIC; DOWN-REGULATION; KIDNEY TUBULES, COLLECTING; LITHIUM; PROTEINS; PROTEOMICS; RATS; SIGNAL TRANSDUCTION;

EID: 42149146711     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800001105     Document Type: Article

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