COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction

American Journal of Physiology - Renal Physiology

Volumn 292, Issue 5, 2007, Pages

  Nørregaard, Rikke ^a   Jensen, Boye L ^b   Topcu, Sukru Oguzkan ^a   Diget, Maria ^a   Schweer, Horst ^e   Knepper, Mark A ^c   Nielsen, Søren ^a   Frøkiær, Jørgen ^a,d  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

AQP2; Cyclooxygenase; NKCC2; Parecoxib; PGE2; Ureteral obstruction; Urine concentrating capacity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AQUAPORIN 2; AQUAPORIN 3; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MESSENGER RNA; PARECOXIB; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTANOID; SODIUM CHLORIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEHYDRATION; DIURESIS; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GLOMERULUS FILTRATION RATE; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; MALE; NATRIURESIS; NONHUMAN; OSMOTIC PUMP; POLYURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SODIUM EXCRETION; URETER OBSTRUCTION; URINARY EXCRETION; URINE OSMOLALITY; URINE VOLUME; WATER DEPRIVATION;

EID: 34247880218     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00394.2006     Document Type: Article

References (38)

1. Castrop H, Vitzthum H, Schumacher K, Schweda F, Kurtz A. Low tonicity mediates a downregulation of cyclooxygenase-1 expression by furosemide in the rat renal papilla. J Am Soc Nephrol 13: 1136-1144, 2002.
2. Cheng X, Zhang H, Lee HL, Park JM. Cyclooxygenase-2 inhibitor preserves medullary aquaporin-2 expression and prevents polyuria after ureteral obstruction. J Urol 172: 2387-2390, 2004.
3. Chou SY, Cai H, Pai D, Mansour M, Huynh P. Regional expression of cyclooxygenase isoforms in the rat kidney in complete unilateral ureteral obstruction. J Urol 170: 1403-1408, 2003.
4. 2-receptor agonist/antagonist treatment. Am J Physiol Renal Physiol 278: F29-F42, 2000.
5. Deen PM, Rijss JP, Mulders SM, Errington RJ, van BJ, van Os CH. Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport. J Am Soc Nephrol 8: 1493-1501, 1997.
6. DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci USA 91: 8984-8988, 1994.
7. Earley LE. Extreme polyuria in obstructive uropathy: report of a case of water-losing nephritis in an infant, with a discussion of polyuria. N Engl J Med 255: 600-605, 1956.
8. Ecelbarger CA, Terris J, Frindt G, Echevarria M, Marples D, Nielsen S, Knepper MA. Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F663-F672, 1995.
9. - cotransporter, BSC-1. Am J Physiol Renal Fluid Electrolyte Physiol 271: F619-F628, 1996.
10. Fernandez-Llama P, Ecelbarger CA, Ware JA, Andrews P, Lee AJ, Turner R, Nielsen S, Knepper MA. Cyclooxygenase inhibitors increase Na-K-2Cl cotransporter abundance in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 277: F219-F226, 1999.
11. Frokiaer J, Knudsen L, Nielsen AS, Pedersen EB, Djurhuus JC. Enhanced intrarenal angiotensin II generation in response to obstruction of the pig ureter. Am J Physiol Renal Fluid Electrolyte Physiol 263: F527-F533, 1992.
12. Frokiaer J, Marples D, Knepper MA, Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 270: F657-F668, 1996.
13. Fushimi K, Sasaki S, Marumo F. Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem 272: 14800-14804, 1997.
14. Hao CM, Yull F, Blackwell T, Komhoff M, Davis LS, Breyer MD. Dehydration activates an NF-κB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. J Clin Invest 106: 973-982, 2000.
15. Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest 94: 2504-2510, 1994.
16. Harris RH, Gill JM. Changes in glomerular filtration rate during complete ureteral obstruction in rats. Kidney Int 19: 603-608, 1981.
17. Harris RH, Yarger WE. The pathogenesis of post-obstructive diuresis. The role of circulating natriuretic and diuretic factors, including urea. J Clin Invest 56: 880-887, 1975.
18. 2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation. Am J Physiol Renal Fluid Electrolyte Physiol 259: F318-F325, 1990.
19. Himmelstein SI, Coffman TM, Yarger WE, Klotman PE. Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction. Am J Physiol Renal Fluid Electrolyte Physiol 258: F281-F286, 1990.
20. Hwang SJ, Haas M, Harris HW Jr, Silva P, Yalla S, Sullivan MR, Otuechere G, Kashgarian M, Zeidel ML. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. J Clin Invest 91: 21-28, 1993.
21. Kashgarian M, Biemesderfer D, Caplan M, Forbush B 3rd. Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments. Kidney Int 28: 899-913, 1985.
22. Kim SW, Cho SH, Oh BS, Yeum CH, Choi KC, Ahn KY, Lee J. Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. J Am Soc Nephrol 12: 2019-2028, 2001.
23. Kotnik P, Nielsen J, Kwon TH, Krzisnik C, Frokiaer J, Nielsen S. Altered expression of COX-1, COX-2, and mPGEs in rats with nephrogenic and central diabetes insipidus. Am J Physiol Renal Physiol 288: F1053-F1068, 2005.
24. Li C, Wang W, Kwon TH, Isikay L, Wen JG, Marples D, Djurhuus JC, Stockwell A, Knepper MA, Nielsen S, Frokiaer J. Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect. Am J Physiol Renal Physiol 281: F163-F171, 2001.
25. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, Frokiaer J. Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction. Am J Physiol Renal Physiol 285: F889-F901, 2003.
26. Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem 278: 19352-19357, 2003.
27. 2 excretion is associated with postobstructive polyuria in human congenital hydronephrosis. J Am Soc Nephrol 15: 2705-2712, 2004.
28. Norregaard R, Jensen BL, Li C, Wang W, Knepper MA, Nielsen S, Frokiaer J. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol 289: F322-F333, 2005.
29. Norregaard R, Jensen BL, Topcu SO, Nielsen SS, Walter S, Djurhuus JC, Frokiaer J. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. Kidney Int 70: 872-881, 2006.
30. Padi SS, Jain NK, Singh S, Kulkarni SK. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. Eur J Pharmacol 491: 69-76, 2004.
31. Ricardo SD, Ding G, Eufemio M, Diamond JR. Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors. Am J Physiol Renal Physiol 272: F789-F798, 1997.
32. Sakairi Y, Jacobson HR, Noland TD, Breyer MD. Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 269: F257-F265, 1995.
33. Schmidt-Nielsen B, Graves B, Roth J. Water removal and solute additions determining increases in renal medullary osmolality. Am J Physiol Renal Fluid Electrolyte Physiol 244: F472-F482, 1983.
34. Schweer H, Watzer B, Seyberth HW. Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionization triple stage quadrupole mass spectrometry. J Chromatogr 652: 221-227, 1994.
35. Sonnenberg H, Wilson DR. The role of the medullary collecting ducts in postobstructive diuresis. J Clin Invest 57: 1564-1574, 1976.
36. Stubbe J, Jensen BL, Bachmann S, Morsing P, Skott O. Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats. Am J Physiol Regul Integr Comp Physiol 284: R1179-R1189, 2003.
37. Yanagisawa H, Moridaira K, Nodera M, Wada O. Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys. Kidney Blood Press Res 20: 398-405, 1997.
38. 2 interaction with AVP: effects on AQP2 phosphorylation and distribution. Am J Physiol Renal Physiol 278: F388-F394, 2000.