Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

Cell Death and Differentiation

Volumn 20, Issue 1, 2013, Pages 139-153

  Lin, H Y ^a,b   Lai, R H ^b   Lin, S T ^b   Lin, R C ^b   Wang, M J ^b   Lin, C C ^a   Lee, H C ^a   Wang, F F ^a   Chen, J Y ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

apoptosis; DRP1; mitochondrial dynamic; PGAM5; SOCS6

Indexed keywords

DRP1 PROTEIN; MEMBRANE PROTEIN; PHOSPHATASE; PHOSPHATASE PGMA5; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 6; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE TRANSLOCATION; MITOCHONDRIAL FISSION; MODULATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; CARRIER PROTEINS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

LENTIVIRUS;

EID: 84870997845     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.106     Document Type: Article

References (41)

1. Garrido C, Galluzzi L, Brunet M, Puig P, Didelot C, Kroemer G. Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 2006; 13: 1423-1433.
2. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15: 2922-2933.
3. Cerveny KL, Tamura Y, Zhang Z, Jensen RE, Sesaki H. Regulation of mitochondrial fusion and division. Trends Cell Biol 2007; 17: 563-569.
4. Chan D. Mitochondria: dynamic organelles in disease, aging, and development. Cell 2006; 125: 1241-1252.
5. Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007; 8: 870-879.
6. Grandemange S, Herzig S, Martinou JC. Mitochondrial dynamics and cancer. Semin Cancer Biol 2009; 19: 50-56.
7. Chen H, Chan DC. Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 2009; 18: R169-R176.
8. Praefcke G, McMahon H. The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 2004; 5: 133-147.
9. Chen H, Detmer S, Ewald A, Griffin E, Fraser S, Chan D. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003; 160: 189-200.
10. Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P et al. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 2003; 278: 7743-7746.
11. Smirnova E, Griparic L, Shurland DL, van der Bliek AM. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 2001; 12: 2245-2256.
12. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010; 191: 1141-1158.
13. James DI, Parone PA, Mattenberger Y, Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 2003; 278: 36373-36379.
14. Wasilewski M, Scorrano L. The changing shape of mitochondrial apoptosis. Trends Endocrinol Metab 2009; 20: 287-294.
15. Chang C-R, Blackstone C. Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann NY Acad Sci 2010; 1201: 34-39.
16. Chang CR, Blackstone C. Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 2007; 282: 21583-21587.
17. Cereghetti G, Stangherlin A, De Brito OM, Chang C, Blackstone C, Bernardi P et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 2008; 105: 15803-15808.
18. Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012; 148: 228-243.
19. Jagasia R, Grote P, Westermann B, Conradt B. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 2005; 433: 754-760.
20. Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001; 1: 515-525.
21. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 2008; 14: 193-204.
22. Cereghetti G, Costa V, Scorrano L. Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin. Cell Death Differ 2010; 17: 1785-1794.
23. Lai RH, Hsiao YW, Wang MJ, Lin HY, Wu CW, Chi CW et al. SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation. Cancer Lett 2010; 288: 75-85.
24. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K et al. Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 1997; 239: 439-446.
25. Nicholson SE, Willson TA, Farley A, Starr R, Zhang JG, Baca M et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J 1999; 18: 375-385.
26. Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP et al. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell 2009; 36: 487-499.
27. Peng JY, Lin CC, Chen YJ, Kao LS, Liu YC, Chou CC et al. Automatic morphological subtyping reveals new roles of caspases in mitochondrial dynamics. PLoS Comput Biol 2011; 7: e1002212.
28. Benard G, Bellance N, James D, Parrone P, Fernandez H, Letellier T et al. Mitochondrial bioenergetics and structural network organization. J Cell Sci 2007; 120: 838-848.
29. Smirnova E, Shurland D, Ryazantsev S, Van Der Bliek A. A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol 1998; 143: 351-358.
30. Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes Dev 2008; 22: 1577-1590.
31. Karbowski M, Jeong SY, Youle RJ. Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol 2004; 166: 1027-1039.
32. Oka T, Sayano T, Tamai S, Yokota S, Kato H, Fujii G et al. Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c. Mol Biol Cell 2008; 19: 2597-2608.
33. Krebs DL, Hilton DJ. A new role for SOCS in insulin action. Suppressor of cytokine signaling. Sci STKE 2003; 2003: PE6.
34. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway R et al. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev 2004; 18: 3055-3065.
35. Karbowski M, Youle RJ. Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol 2011; 23: 476-482.
36. Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S. MARCH-V is a novel mitofusin 2-and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep 2006; 7: 1019-1022.
37. Wang H, Song P, Du L, Tian W, Yue W, Liu M et al. Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem 2011; 286: 11649-11658.
38. Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS et al. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem 2011; 286: 480-490.
39. Louis N, Evelegh C, Graham FL. Cloning and sequencing of the cellular-viral junctions from the human adenovirus type 5 transformed 293 cell line. Virology 1997; 233: 423-429.
40. Lai R, Wang M, Yang S, Chen J. Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene. Gene 2009; 448: 64-73.
41. Lee JL, Wang MJ, Sudhir PR, Chen JY. CD44 engagement promotes matrix-derived survival through the CD44-SRC-integrin axis in lipid rafts. Mol Cell Biol 2008; 28: 5710-5723.