Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5833-5838

  Ochiai, Koji ^a   Takita, Satoshi ^a   Kojima, Akihiko ^a   Eiraku, Tomohiko ^a   Ando, Naoki ^a   Iwase, Kazuhiko ^a   Kishi, Tetsuya ^a   Ohinata, Akira ^a   Yageta, Yuichi ^a   Yasue, Tokutaro ^a   Adams, David R ^b   Kohno, Yasushi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Asthma; COPD; Dimethylpyrazolone; Dual PDE3 4 inhibitor; Pyrazolo 1,5 a pyridine

Indexed keywords

3 [8 METHOXY 2 (TRIFLUOROMETHYL)IMIDAZO[1,2 A]PYRIDIN 5 YL] 4,4 DIMETHYL 1H PYRAZOL 5 (4H)ONE; 4 HYDROXYPYRAZOLO[1,5 A]PYRIDINE; 4,4 DIMETHYLPYRAZOLONE DERIVATIVE; 5 METHYL 4,5 DIHYDROPYRIDAZIN 3 (2H)ONE; 6 (2 ETHYL 7 METHOXYPYRAZOLO[1,5 A]PYRIDIN 4 YL) 5 METHYL 4,5 DIHYDRO 3 (2H)PYRIDAZINONE; 6 (7 METHOXY 2 TRIFLUOROMETHYLPYRAZOLO[1,5 A]PYRIDIN 4 YL) 5 METHYL 4,5 DIHYDRO 3 (2H) PYRIDAZINONE; 6 [4 [[2 (3 IODOBENZYL) 3 OXOCYCLOHEX 1 EN 1 YL]AMINO]PHENYL] 5 METHYL 4,5 DIHYDROPYRIDAZIN 3 (2H)ONE; ANTIINFLAMMATORY AGENT; BRONCHODILATING AGENT; KCA 1490; KETONE; N AMINOPYRIDINIUM; O MESITYLENESULFONYLHYDROXYLAMINE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PYRAZOLO[1,5 A]PYRIDINE; PYRAZOLOPYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZARDAVERINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DECARBOXYLATION; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; OXIDATION; STRUCTURE ACTIVITY RELATION;

BICYCLO COMPOUNDS, HETEROCYCLIC; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PYRAZOLONES; PYRIDAZINES; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865522622     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.088     Document Type: Article

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