Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes

Journal of Toxicological Sciences

Volumn 37, Issue 6, 2012, Pages 1275-1278

  Kim, Min Seok ^a   Takahashi, Tsutomu ^a   Lee, Jin Yong ^a,b   Hwang, Gi Wook ^a   Naganuma, Akira ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

CCL2; Chemokine; Methylmercury; NF B

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; METHYLMERCURY; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR RELA;

ASTROCYTE; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; HUMAN; HUMAN CELL; LETTER; NEUROTOXICITY; POLLUTANT; PROTEIN EXPRESSION; RNA INTERFERENCE;

EID: 84870921225     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.1275     Document Type: Letter

References (15)

1. Castoldi, A.F., Coccini, T. and Manzo, L. (2003): Neurotoxic and molecular effects of methylmercury in humans. Rev. Environ. Health, 18, 19-31.
2. Fujimura, M., Usuki, F., Sawada, M. and Takashima, A. (2009): Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology, 30, 1000-1007.
3. Ghosh, S., May, M.J. and Kopp, E.B. (1998): NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol., 16, 225-260.
4. Giraud, S.N., Caron, C.M., Pham-Dinh, D., Kitabgi, P. and Nicot, A.B. (2010): Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes. Proc. Natl. Acad. Sci. USA, 107, 8416-8421.
5. Godefroy, D., Gosselin, R.D., Yasutake, A., Fujimura, M., Combadiere, C., Maury-Brachet, R., Laclau, M., Rakwal, R., Melik-Parsadaniantz, S., Bourdineaud, J.P. and Rostene, W. (2012): The chemokine CCL2 protects against methylmercury neurotoxicity. Toxicol. Sci., 125, 209-218.
6. Hirooka, T., Fujiwara, Y., Shinkai, Y., Yamamoto, C., Yasutake, A., Satoh, M., Eto, K. and Kaji, T. (2010): Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. J. Toxicol. Sci., 35, 287-294.
7. Hoffmann, A. and Baltimore, D. (2006): Circuitry of nuclear factor kappaB signaling. Immunol. Rev., 210, 171-186.
8. Hwang, G.W., Du, K., Takahashi, T. and Naganuma, A. (2011a): Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells. J. Toxicol. Sci., 36, 847-849.
9. Hwang, G.W., Lee, J.Y., Ryoke, K., Matsuyama, F., Kim, J.M., Takahashi, T. and Naganuma, A. (2011b): Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury. J. Toxicol. Sci., 36, 389-391.
10. Ito, S., Sawada, M., Haneda, M., Ishida, Y. and Isobe, K. (2006): Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/ Akt and/or ERK pathway. Neurosci. Res., 56, 294-299.
11. Kuper, C., Beck, F.X. and Neuhofer, W. (2012): NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells. Mediators Inflamm., 2012, 513015.
12. Min, K.J., Jang, J.H. and Kwon, T.K. (2012): Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-kappaB and STAT/GAS activity. J. Pineal Res., 52, 296-304.
13. Murdoch, C. and Finn, A. (2000): Chemokine receptors and their role in inflammation and infectious diseases. Blood, 95, 3032-3043.
14. Sumi, D., Akimori, M., Inoue, K., Takano, H. and Kumagai, Y. (2010): 1,2-Naphthoquinone suppresses lipopolysaccharidedependent activation of IKKbeta/NF-kappaB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation. J. Toxicol. Sci., 35, 891-898.
15. Takahashi, T., Satake, S., Hirose, K., Hwang, G.W. and Naganuma, A. (2011): A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae. J. Toxicol. Sci., 36, 859-861.