Effects of degree of quaternization on the preparation and characterization of insulin-loaded trimethyl chitosan polyelectrolyte complexes optimized by central composite design

Pharmaceutical Development and Technology

Volumn 17, Issue 6, 2012, Pages 719-729

  Jin, Yun ^a   Zhou, Dan ^a   Yang, Hong Yun ^a   Zhu, Xi ^a   Wang, Xiao Ran ^a   Zhang, Zhi Rong ^a   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Central composite design; Degree of quaternization; N trimethyl chitosan chloride; Polyelectrolyte complex

Indexed keywords

CHITOSAN DERIVATIVE; INSULIN; MUCIN; N TRIMETHYLCHITOSAN CHLORIDE; POLYELECTROLYTE; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DESIGN; DRUG FORMULATION; DRUG STABILITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOLECULAR INTERACTION; MORPHOLOGY; MUCOADHESION; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY; STATIC ELECTRICITY; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADHESIVES; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG CARRIERS; DRUG DESIGN; DRUG STABILITY; ELECTROLYTES; INSULIN; MUCINS; NANOPARTICLES; PARTICLE SIZE; SOLUBILITY; STATIC ELECTRICITY;

EID: 84870915057     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2011.580757     Document Type: Article

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