The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5

Neuropharmacology

Volumn 65, Issue , 2013, Pages 232-243

  Peng, Yi Rong ^a   Hou, Zai Hua ^a,b   Yu, Xiang ^a  

^a Chinese Academy of Sciences   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Cdk5; EphA4; Homeostatic plasticity; Neuronal activity; Synaptic scaling

Indexed keywords

CYCLIN DEPENDENT KINASE 5; EPHRIN A1; EPHRIN RECEPTOR A4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE OVEREXPRESSION; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; NERVE CELL CHARACTERISTICS AND FUNCTIONS; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; RNA INTERFERENCE; SYNAPTIC STRENGTH; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HEK293 CELLS; HOMEOSTASIS; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPHA4; SYNAPSES;

EID: 84870900044     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.10.012     Document Type: Article

References (55)

1. L.F. Abbott, and S.B. Nelson Synaptic plasticity: taming the beast Nat. Neurosci. 3 Suppl. 2000 1178 1183
2. J. Aoto, and L. Chen Bidirectional ephrin/Eph signaling in synaptic functions Brain Res. 1184 2007 72 80
3. J. Aoto, C.I. Nam, M.M. Poon, P. Ting, and L. Chen Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity Neuron 60 2008 308 320
4. G. Bi, and M. Poo Synaptic modification by correlated activity: Hebb's postulate revisited Annu. Rev. Neurosci. 24 2001 139 166
5. C. Bourgin, K.K. Murai, M. Richter, and E.B. Pasquale The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways J. Cell Biol. 178 2007 1295 1307
6. J. Burrone, and V.N. Murthy Synaptic gain control and homeostasis Curr. Opin. Neurobiol. 13 2003 560 567
7. L.A. Cingolani, A. Thalhammer, L.M. Yu, M. Catalano, T. Ramos, M.A. Colicos, and Y. Goda Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins Neuron 58 2008 749 762
8. G.W. Davis Homeostatic control of neural activity: from phenomenology to molecular design Annu. Rev. Neurosci. 29 2006 307 323
9. J. Egea, U.V. Nissen, A. Dufour, M. Sahin, P. Greer, K. Kullander, T.D. Mrsic-Flogel, M.E. Greenberg, O. Kiehn, P. Vanderhaeghen, and R. Klein Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function Neuron 47 2005 515 528
10. J.G. Flanagan Neural map specification by gradients Curr. Opin. Neurobiol. 16 2006 59 66
11. J.G. Flanagan, and P. Vanderhaeghen The ephrins and Eph receptors in neural development Annu. Rev. Neurosci. 21 1998 309 345
12. A.K. Fu, K.W. Hung, W.Y. Fu, C. Shen, Y. Chen, J. Xia, K.O. Lai, and N.Y. Ip APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity Nat. Neurosci. 14 2011 181 189
13. W.Y. Fu, Y. Chen, M. Sahin, X.S. Zhao, L. Shi, J.B. Bikoff, K.O. Lai, W.H. Yung, A.K. Fu, M.E. Greenberg, and N.Y. Ip Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism Nat. Neurosci. 10 2007 67 76
14. M.A. Gainey, J.R. Hurvitz-Wolff, M.E. Lambo, and G.G. Turrigiano Synaptic scaling requires the GluR2 subunit of the AMPA receptor J. Neurosci. 29 2009 6479 6489
15. R. Gerlai Eph receptors and neural plasticity Nat. Rev. Neurosci. 2 2001 205 209
16. M. Hruska, and M.B. Dalva Ephrin regulation of synapse formation, function and plasticity Mol. Cell. Neurosci. 50 2012 35 44
17. S.H. Kim, and T.A. Ryan CDK5 serves as a major control point in neurotransmitter release Neuron 67 2010 797 809
18. R. Klein Eph/ephrin signaling in morphogenesis, neural development and plasticity Curr. Opin. Cell Biol. 16 2004 580 589
19. R. Klein Bidirectional modulation of synaptic functions by Eph/ephrin signaling Nat. Neurosci. 12 2009 15 20
20. K. Kullander, and R. Klein Mechanisms and functions of Eph and ephrin signalling Nat. Rev. Mol. Cell Biol. 3 2002 475 486
21. K. Kullander, N.K. Mather, F. Diella, M. Dottori, A.W. Boyd, and R. Klein Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo Neuron 29 2001 73 84
22. K.O. Lai, and N.Y. Ip Synapse development and plasticity: roles of ephrin/Eph receptor signaling Curr. Opin. Neurobiol. 19 2009 275 283
23. D.J. Liebl, C.J. Morris, M. Henkemeyer, and L.F. Parada mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system J. Neurosci. Res. 71 2003 7 22
24. H. Lin, M.C. Chen, and C.T. Ku Cyclin-dependent kinase 5 regulates steroidogenic acute regulatory protein and androgen production in mouse Leydig cells Endocrinology 150 2009 396 403
25. R.C. Malenka, and M.F. Bear LTP and LTD: an embarrassment of riches Neuron 44 2004 5 21
26. T. McLaughlin, and D.D. O'Leary Molecular gradients and development of retinotopic maps Annu. Rev. Neurosci. 28 2005 327 355
27. A. Mitra, S.S. Mitra, and R.W. Tsien Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity Nat. Neurosci. 15 2012 250 257
28. K.K. Murai, L.N. Nguyen, F. Irie, Y. Yamaguchi, and E.B. Pasquale Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling Nat. Neurosci. 6 2003 153 160
29. D.D. O'Leary, and D.G. Wilkinson Eph receptors and ephrins in neural development Curr. Opin. Neurobiol. 9 1999 65 73
30. D.T. Pak, and M. Sheng Targeted protein degradation and synapse remodeling by an inducible protein kinase Science 302 2003 1368 1373
31. E.B. Pasquale Eph-ephrin bidirectional signaling in physiology and disease Cell 133 2008 38 52
32. Y.R. Peng, S. He, H. Marie, S.Y. Zeng, J. Ma, Z.J. Tan, S.Y. Lee, R.C. Malenka, and X. Yu Coordinated changes in dendritic arborization and synaptic strength during neural circuit development Neuron 61 2009 71 84
33. Y.R. Peng, S.Y. Zeng, H.L. Song, M.Y. Li, M.K. Yamada, and X. Yu Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling J. Neurosci. 30 2010 16220 16231
34. M.M. Rich, and P. Wenner Sensing and expressing homeostatic synaptic plasticity Trends Neurosci. 30 2007 119 125
35. M. Richter, K.K. Murai, C. Bourgin, D.T. Pak, and E.B. Pasquale The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases J. Neurosci. 27 2007 14205 14215
36. D.P. Seeburg, M. Feliu-Mojer, J. Gaiottino, D.T. Pak, and M. Sheng Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron 58 2008 571 583
37. D.P. Seeburg, and M. Sheng Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity J. Neurosci. 28 2008 6583 6591
38. S.M. Shamah, M.Z. Lin, J.L. Goldberg, S. Estrach, M. Sahin, L. Hu, M. Bazalakova, R.L. Neve, G. Corfas, A. Debant, and M.E. Greenberg EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin Cell 105 2001 233 244
39. C.J. Shatz Impulse activity and the patterning of connections during CNS development Neuron 5 1990 745 756
40. D. Stellwagen, and R.C. Malenka Synaptic scaling mediated by glial TNF-alpha Nature 440 2006 1054 1059
41. G.S. Stent A physiological mechanism for Hebb's postulate of learning Proc. Natl. Acad. Sci. U.S.A. 70 1973 997 1001
42. S.C. Su, and L.H. Tsai Cyclin-dependent kinases in brain development and disease Annu. Rev. Cell. Dev. Biol. 27 2011 465 491
43. M.A. Sutton, H.T. Ito, P. Cressy, C. Kempf, J.C. Woo, and E.M. Schuman Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis Cell 125 2006 785 799
44. D. Teis, and L.A. Huber The odd couple: signal transduction and endocytosis Cell. Mol. Life Sci. 60 2003 2020 2033
45. K. Tomizawa, J. Ohta, M. Matsushita, A. Moriwaki, S.T. Li, K. Takei, and H. Matsui Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity J. Neurosci. 22 2002 2590 2597
46. M.E. Tremblay, M. Riad, D. Bouvier, K.K. Murai, E.B. Pasquale, L. Descarries, and G. Doucet Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus J. Comp. Neurol. 501 2007 691 702
47. L.H. Tsai, T. Takahashi, V.S. Caviness Jr.; and E. Harlow Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system Development 119 1993 1029 1040
48. G.G. Turrigiano The self-tuning neuron: synaptic scaling of excitatory synapses Cell 135 2008 422 435
49. G.G. Turrigiano, K.R. Leslie, N.S. Desai, L.C. Rutherford, and S.B. Nelson Activity-dependent scaling of quantal amplitude in neocortical neurons Nature 391 1998 892 896
50. G.G. Turrigiano, and S.B. Nelson Homeostatic plasticity in the developing nervous system Nat. Rev. Neurosci. 5 2004 97 107
51. C.J. Wierenga, K. Ibata, and G.G. Turrigiano Postsynaptic expression of homeostatic plasticity at neocortical synapses J. Neurosci. 25 2005 2895 2905
52. C.J. Wierenga, M.F. Walsh, and G.G. Turrigiano Temporal regulation of the expression locus of homeostatic plasticity J. Neurophysiol. 96 2006 2127 2133
53. L.M. Yu, and Y. Goda Dendritic signalling and homeostatic adaptation Curr. Opin. Neurobiol. 19 2009 327 335
54. X. Yu, and R.C. Malenka Beta-catenin is critical for dendritic morphogenesis Nat. Neurosci. 6 2003 1169 1177
55. L. Zhou, S.J. Martinez, M. Haber, E.V. Jones, D. Bouvier, G. Doucet, A.T. Corera, E.A. Fon, A.H. Zisch, and K.K. Murai EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology J. Neurosci. 27 2007 5127 5138