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Volumn 11, Issue 12, 2012, Pages 5959-5971

HILIC- and SCX-based quantitative proteomics of chlamydomonas reinhardtii during nitrogen starvation induced lipid and carbohydrate accumulation

Author keywords

biofuels; carbohydrate production; Chlamydomonas; HILIC; iTRAQ; lipid production; quantitative proteomics; SCX

Indexed keywords

BIOFUEL; CARBOHYDRATE; LIPID; NITROGEN;

EID: 84870893631     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr300692t     Document Type: Article
Times cited : (63)

References (60)
  • 1
    • 72049083209 scopus 로고    scopus 로고
    • Biofuels from microalgae-A review of technologies for production, processing, and extractions of biofuels and co-products
    • Brennan, L.; Owende, P. Biofuels from microalgae-A review of technologies for production, processing, and extractions of biofuels and co-products Renewable Sustainable Energy Rev. 2010, 14 (2) 557-577
    • (2010) Renewable Sustainable Energy Rev. , vol.14 , Issue.2 , pp. 557-577
    • Brennan, L.1    Owende, P.2
  • 2
    • 39149105620 scopus 로고    scopus 로고
    • Biodiesel from microalgae beats bioethanol
    • Chisti, Y. Biodiesel from microalgae beats bioethanol Trends Biotechnol. 2008, 26 (3) 126-131
    • (2008) Trends Biotechnol. , vol.26 , Issue.3 , pp. 126-131
    • Chisti, Y.1
  • 3
    • 33947617349 scopus 로고    scopus 로고
    • Biodiesel from microalgae
    • Chisti, Y. Biodiesel from microalgae Biotechnol. Adv. 2007, 25 (3) 294-306
    • (2007) Biotechnol. Adv. , vol.25 , Issue.3 , pp. 294-306
    • Chisti, Y.1
  • 5
    • 79751504508 scopus 로고    scopus 로고
    • The economics of producing biodiesel from algae
    • Gallagher, B. J. The economics of producing biodiesel from algae Renewable Energy 2011, 36 (1) 158-162
    • (2011) Renewable Energy , vol.36 , Issue.1 , pp. 158-162
    • Gallagher, B.J.1
  • 7
    • 84985224950 scopus 로고
    • Phytoplankton lipids: Interspecific differences and effects of nitrate, silicate and light-dark cycle
    • Shifrin, N. S.; Chisholm, S. W. Phytoplankton lipids: Interspecific differences and effects of nitrate, silicate and light-dark cycle J. Phycol. 1981, 17 (4) 374-384
    • (1981) J. Phycol. , vol.17 , Issue.4 , pp. 374-384
    • Shifrin, N.S.1    Chisholm, S.W.2
  • 8
    • 70350353205 scopus 로고    scopus 로고
    • Lipid productivity as a key characteristic for choosing algal species for biodiesel production
    • Griffiths, M. J.; Harrison, S. T. L. Lipid productivity as a key characteristic for choosing algal species for biodiesel production J. Appl. Phycol. 2009, 21 (5) 493-507
    • (2009) J. Appl. Phycol. , vol.21 , Issue.5 , pp. 493-507
    • Griffiths, M.J.1    Harrison, S.T.L.2
  • 10
    • 70349871611 scopus 로고    scopus 로고
    • Milking diatoms for sustainable energy: Biochemical engineering versus gasoline-secreting diatom solar panels
    • Ramachandra, T. V.; Mahapatra, D. M.; B, K.; Gordon, R. Milking diatoms for sustainable energy: Biochemical engineering versus gasoline-secreting diatom solar panels Ind. Eng. Chem. Res. 2009, 48 (19) 8769-8788
    • (2009) Ind. Eng. Chem. Res. , vol.48 , Issue.19 , pp. 8769-8788
    • Ramachandra, T.V.1    Mahapatra, D.M.2    Gordon, R.3
  • 14
    • 73349097525 scopus 로고    scopus 로고
    • Algal lipid bodies: Stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii
    • Wang, Z. T.; Ullrich, N.; Joo, S.; Waffenschmidt, S.; Goodenough, U. Algal lipid bodies: Stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii Eukaryotic Cell 2009, 8 (12) 1856-1868
    • (2009) Eukaryotic Cell , vol.8 , Issue.12 , pp. 1856-1868
    • Wang, Z.T.1    Ullrich, N.2    Joo, S.3    Waffenschmidt, S.4    Goodenough, U.5
  • 15
    • 75649112263 scopus 로고    scopus 로고
    • RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii
    • Moellering, E. R.; Benning, C. RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii Eukaryotic Cell 2010, 9 (1) 97-106
    • (2010) Eukaryotic Cell , vol.9 , Issue.1 , pp. 97-106
    • Moellering, E.R.1    Benning, C.2
  • 17
    • 57249105121 scopus 로고    scopus 로고
    • Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models
    • Rogers, S.; Girolami, M.; Kolch, W.; Waters, K. M.; Liu, T.; Thrall, B.; Wiley, S. H. Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models Bioinformatics 2008, 24 (24) 2894-2900
    • (2008) Bioinformatics , vol.24 , Issue.24 , pp. 2894-2900
    • Rogers, S.1    Girolami, M.2    Kolch, W.3    Waters, K.M.4    Liu, T.5    Thrall, B.6    Wiley, S.H.7
  • 18
    • 64149091633 scopus 로고    scopus 로고
    • Omics in algae: Paving the way for a systems biological understanding of algal stress phenomena?
    • Jamers, A.; Blust, R.; De Coen, W. Omics in algae: Paving the way for a systems biological understanding of algal stress phenomena? Aquat. Toxicol. 2009, 92 (3) 114-121
    • (2009) Aquat. Toxicol. , vol.92 , Issue.3 , pp. 114-121
    • Jamers, A.1    Blust, R.2    De Coen, W.3
  • 19
    • 79953197928 scopus 로고    scopus 로고
    • Improving biofuel production in phototrophic microorganisms with systems biology
    • Jinkerson, R. E.; Subramanian, V.; Posewitz, M. C. Improving biofuel production in phototrophic microorganisms with systems biology Biofuels 2011, 2 (2) 125-144
    • (2011) Biofuels , vol.2 , Issue.2 , pp. 125-144
    • Jinkerson, R.E.1    Subramanian, V.2    Posewitz, M.C.3
  • 20
    • 13444266075 scopus 로고    scopus 로고
    • Chlamydomonas reinhardtii proteomics
    • Stauber, E. J.; Hippler, M. Chlamydomonas reinhardtii proteomics Plant Physiol. Biochem. 2004, 42 (12) 989-1001
    • (2004) Plant Physiol. Biochem. , vol.42 , Issue.12 , pp. 989-1001
    • Stauber, E.J.1    Hippler, M.2
  • 22
    • 84934440046 scopus 로고    scopus 로고
    • Isolation and proteomic analysis of Chlamydomonas centrioles
    • Keller, L. C.; Marshall, W. F. Isolation and proteomic analysis of Chlamydomonas centrioles Methods Mol. Biol. 2008, 432, 289-300
    • (2008) Methods Mol. Biol. , vol.432 , pp. 289-300
    • Keller, L.C.1    Marshall, W.F.2
  • 23
    • 66749108480 scopus 로고    scopus 로고
    • A proteomic survey of Chlamydomonas reinhardtii mitochondria sheds new light on the metabolic plasticity of the organelle and on the nature of the alpha-proteobacterial mitochondrial ancestor
    • Atteia, A.; Adrait, A.; BrugieIre, S.; Tardif, M.; van Lis, R.; Deusch, O.; Dagan, T.; Kuhn, L.; Gontero, B.; Martin, W.; Garin, J.; Joyard, J.; Rolland, N. A proteomic survey of Chlamydomonas reinhardtii mitochondria sheds new light on the metabolic plasticity of the organelle and on the nature of the alpha-proteobacterial mitochondrial ancestor Mol. Biol. Evol. 2009, 26 (7) 1533-1548
    • (2009) Mol. Biol. Evol. , vol.26 , Issue.7 , pp. 1533-1548
    • Atteia, A.1    Adrait, A.2    Brugieire, S.3    Tardif, M.4    Van Lis, R.5    Deusch, O.6    Dagan, T.7    Kuhn, L.8    Gontero, B.9    Martin, W.10    Garin, J.11    Joyard, J.12    Rolland, N.13
  • 24
    • 67649198519 scopus 로고    scopus 로고
    • Application of quantitative immunoprecipitation combined with knockdown and cross-linking to Chlamydomonas reveals the presence of vesicle-inducing protein in plastids 1 in a common complex with chloroplast HSP90C
    • Heide, H.; Nordhues, A.; Drepper, F.; Nick, S.; Schulz-Raffelt, M.; Haehnel, W.; Schroda, M. Application of quantitative immunoprecipitation combined with knockdown and cross-linking to Chlamydomonas reveals the presence of vesicle-inducing protein in plastids 1 in a common complex with chloroplast HSP90C Proteomics 2009, 9 (11) 3079-3089
    • (2009) Proteomics , vol.9 , Issue.11 , pp. 3079-3089
    • Heide, H.1    Nordhues, A.2    Drepper, F.3    Nick, S.4    Schulz-Raffelt, M.5    Haehnel, W.6    Schroda, M.7
  • 26
    • 77952334099 scopus 로고    scopus 로고
    • Proteomic analysis of the response of an acidophilic strain of Chlamydomonas sp. (Chlorophyta) to natural metal-rich water
    • Cid, C.; Garcia-Descalzo, L.; Casado-Lafuente, V.; Amils, R.; Aguilera, A. Proteomic analysis of the response of an acidophilic strain of Chlamydomonas sp. (Chlorophyta) to natural metal-rich water Proteomics 2010, 10 (10) 2026-2036
    • (2010) Proteomics , vol.10 , Issue.10 , pp. 2026-2036
    • Cid, C.1    Garcia-Descalzo, L.2    Casado-Lafuente, V.3    Amils, R.4    Aguilera, A.5
  • 28
    • 84934435280 scopus 로고    scopus 로고
    • Probing circadian rhythms in Chlamydomonas rheinhardtii by functional proteomics
    • Wagner, V.; Mittag, M. Probing circadian rhythms in Chlamydomonas rheinhardtii by functional proteomics Methods Mol. Biol. 2009, 479, 173-188
    • (2009) Methods Mol. Biol. , vol.479 , pp. 173-188
    • Wagner, V.1    Mittag, M.2
  • 29
    • 0034662907 scopus 로고    scopus 로고
    • Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology
    • Gygi, S. P.; Corthals, G. L.; Zhang, Y.; Rochon, Y.; Aebersold, R. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (17) 9390-9395
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , Issue.17 , pp. 9390-9395
    • Gygi, S.P.1    Corthals, G.L.2    Zhang, Y.3    Rochon, Y.4    Aebersold, R.5
  • 30
    • 0036583926 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    • Ong, S.-E.; Blagoev, B.; Kratchmarova, I.; Kristensen, D. B.; Steen, H.; Pandey, A.; Mann, M. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics Mol. Cell. Proteomics 2002, 1 (5) 376-386
    • (2002) Mol. Cell. Proteomics , vol.1 , Issue.5 , pp. 376-386
    • Ong, S.-E.1    Blagoev, B.2    Kratchmarova, I.3    Kristensen, D.B.4    Steen, H.5    Pandey, A.6    Mann, M.7
  • 32
    • 33644845960 scopus 로고    scopus 로고
    • Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D Gel- or LC-MALDI TOF/TOF
    • Wu, W. W.; Wang, G.; Baek, S. J.; Shen, R.-F. Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D Gel- or LC-MALDI TOF/TOF J. Proteome Res. 2006, 5 (3) 651-658
    • (2006) J. Proteome Res. , vol.5 , Issue.3 , pp. 651-658
    • Wu, W.W.1    Wang, G.2    Baek, S.J.3    Shen, R.-F.4
  • 33
    • 84859103646 scopus 로고    scopus 로고
    • 15N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii
    • 15N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii Mol. Cell. Proteomics 2011, 10, 9
    • (2011) Mol. Cell. Proteomics , vol.10 , pp. 9
    • Mühlhaus, T.1    Weiss, J.2    Hemme, D.3    Sommer, F.4    Schroda, M.5
  • 34
    • 77952825427 scopus 로고    scopus 로고
    • Characterizing the anaerobic response of Chlamydomonas reinhardtii by quantitative proteomics
    • Terashima, M.; Specht, M.; Naumann, B.; Hippler, M. Characterizing the anaerobic response of Chlamydomonas reinhardtii by quantitative proteomics Mol. Cell. Proteomics 2010, 9 (7) 1514-1532
    • (2010) Mol. Cell. Proteomics , vol.9 , Issue.7 , pp. 1514-1532
    • Terashima, M.1    Specht, M.2    Naumann, B.3    Hippler, M.4
  • 35
    • 36048942406 scopus 로고    scopus 로고
    • Comparative quantitative proteomics to investigate the remodeling of bioenergetic pathways under iron deficiency in Chlamydomonas reinhardtii
    • Naumann, B.; Busch, A.; Allmer, J.; Ostendorf, E.; Zeller, M.; Kirchhoff, H.; Hippler, M. Comparative quantitative proteomics to investigate the remodeling of bioenergetic pathways under iron deficiency in Chlamydomonas reinhardtii Proteomics 2007, 7 (21) 3964-3979
    • (2007) Proteomics , vol.7 , Issue.21 , pp. 3964-3979
    • Naumann, B.1    Busch, A.2    Allmer, J.3    Ostendorf, E.4    Zeller, M.5    Kirchhoff, H.6    Hippler, M.7
  • 37
    • 84862923173 scopus 로고    scopus 로고
    • Comprehensive comparison of iTRAQ and label-free LC-based quantitative proteomics approaches using two Chlamydomonas reinhardtii strains of interest for biofuels engineering
    • Wang, H.; Alvarez, S.; Hicks, L. M. Comprehensive comparison of iTRAQ and label-free LC-based quantitative proteomics approaches using two Chlamydomonas reinhardtii strains of interest for biofuels engineering J. Proteome Res. 2011, 11 (1) 487-501
    • (2011) J. Proteome Res. , vol.11 , Issue.1 , pp. 487-501
    • Wang, H.1    Alvarez, S.2    Hicks, L.M.3
  • 38
    • 84867161579 scopus 로고    scopus 로고
    • System response of metabolic networks in Chlamydomonas reinhardtii to total available ammonium
    • Lee, D. Y.; Park, J.-J.; Barupal, D. K.; Fiehn, O. System response of metabolic networks in Chlamydomonas reinhardtii to total available ammonium Mol. Cell. Proteomics 2012, 11 (10) 973-988
    • (2012) Mol. Cell. Proteomics , vol.11 , Issue.10 , pp. 973-988
    • Lee, D.Y.1    Park, J.-J.2    Barupal, D.K.3    Fiehn, O.4
  • 39
    • 78651569539 scopus 로고    scopus 로고
    • Oil accumulation in the model green alga Chlamydomonas reinhardtii: Characterization, variability between common laboratory strains and relationship with starch reserves
    • Siaut, M.; Cuiné, S.; Cagnon, C.; Fessler, B.; Nguyen, M.; Carrier, P.; Beyly, A.; Beisson, F.; TriantaphylideIs, C.; Li-Beisson, Y.; Peltier, G. Oil accumulation in the model green alga Chlamydomonas reinhardtii: characterization, variability between common laboratory strains and relationship with starch reserves BMC Biotechnol. 2011, 11 (1) 7
    • (2011) BMC Biotechnol. , vol.11 , Issue.1 , pp. 7
    • Siaut, M.1    Cuiné, S.2    Cagnon, C.3    Fessler, B.4    Nguyen, M.5    Carrier, P.6    Beyly, A.7    Beisson, F.8    Triantaphylideis, C.9    Li-Beisson, Y.10    Peltier, G.11
  • 40
    • 84863350333 scopus 로고    scopus 로고
    • Genetic transformation of the model green alga C hlamydomonas reinhardtii
    • Neupert, J.; Shao, N.; Lu, Y.; Bock, R. Genetic transformation of the model green alga C hlamydomonas reinhardtii Methods Mol. Biol. 2012, 847, 35-47
    • (2012) Methods Mol. Biol. , vol.847 , pp. 35-47
    • Neupert, J.1    Shao, N.2    Lu, Y.3    Bock, R.4
  • 41
    • 82155166288 scopus 로고    scopus 로고
    • Flocculation of wall-deficient cells of Chlamydomonas reinhardtii mutant cw15 by calcium and methanol
    • Scholz, M.; Hoshino, T.; Johnson, D.; Riley, M. R.; Cuello, J. Flocculation of wall-deficient cells of Chlamydomonas reinhardtii mutant cw15 by calcium and methanol Biomass Bioenergy 2011, 35 (12) 4835-4840
    • (2011) Biomass Bioenergy , vol.35 , Issue.12 , pp. 4835-4840
    • Scholz, M.1    Hoshino, T.2    Johnson, D.3    Riley, M.R.4    Cuello, J.5
  • 42
    • 0346355321 scopus 로고    scopus 로고
    • Transformation of Chlamydomonas reinhardtii CW-15 with the hygromycin phosphotransferase gene as a selectable marker
    • Ladygin, V. G.; Boutanaev, A. M. Transformation of Chlamydomonas reinhardtii CW-15 with the hygromycin phosphotransferase gene as a selectable marker Russ. J. Genet. 2002, 38 (9) 1009-1014
    • (2002) Russ. J. Genet. , vol.38 , Issue.9 , pp. 1009-1014
    • Ladygin, V.G.1    Boutanaev, A.M.2
  • 43
    • 84857246193 scopus 로고    scopus 로고
    • Acclimation of Chlamydomonas reinhardtii to different growth irradiances
    • Bonente, G.; Pippa, S.; Castellano, S.; Bassi, R.; Ballottari, M. Acclimation of Chlamydomonas reinhardtii to different growth irradiances J. Biol. Chem. 2012, 287 (8) 5833-5847
    • (2012) J. Biol. Chem. , vol.287 , Issue.8 , pp. 5833-5847
    • Bonente, G.1    Pippa, S.2    Castellano, S.3    Bassi, R.4    Ballottari, M.5
  • 44
    • 84870887524 scopus 로고    scopus 로고
    • Micro-algae as a Model System for Studying of Genotype Resistance to Oxidative Stress and Adaptive Response
    • Mothersill, C. E. Korogodina, V. Seymour, C. B. NATO Science for Peace and Security Series C: Environmental Security; Springer: The Netherlands
    • Chankova, S. G.; Yurina, N. Micro-algae as a Model System for Studying of Genotype Resistance to Oxidative Stress and Adaptive Response. In Radiobiology and Environmental Security; Mothersill, C. E.; Korogodina, V.; Seymour, C. B., Eds.; NATO Science for Peace and Security Series C: Environmental Security; Springer: The Netherlands, 2012; pp 19-30.
    • (2012) Radiobiology and Environmental Security , pp. 19-30
    • Chankova, S.G.1    Yurina, N.2
  • 45
    • 84974489639 scopus 로고
    • Genetical and structural analyses of cell-wall formation in Chlamydomonas reinhardtii
    • Davies, D. R.; Plaskitt, A. Genetical and structural analyses of cell-wall formation in Chlamydomonas reinhardtii Genet. Res. 1971, 17 (01) 33-43
    • (1971) Genet. Res. , vol.17 , Issue.1 , pp. 33-43
    • Davies, D.R.1    Plaskitt, A.2
  • 48
    • 0028007844 scopus 로고
    • The spectral determination of chlorophylls a and b, as well as total carotenoids, using various solvents with spectrophotometers of different resolution
    • Wellburn, R. W. The spectral determination of chlorophylls a and b, as well as total carotenoids, using various solvents with spectrophotometers of different resolution J. Plant Physiol. 1994, 144 (3) 307-313
    • (1994) J. Plant Physiol. , vol.144 , Issue.3 , pp. 307-313
    • Wellburn, R.W.1
  • 50
    • 62349095514 scopus 로고    scopus 로고
    • A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae
    • Chen, W.; Zhang, C.; Song, L.; Sommerfeld, M.; Hu, Q. A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae J. Microbiol. Methods 2009, 77 (1) 41-47
    • (2009) J. Microbiol. Methods , vol.77 , Issue.1 , pp. 41-47
    • Chen, W.1    Zhang, C.2    Song, L.3    Sommerfeld, M.4    Hu, Q.5
  • 51
    • 70449412362 scopus 로고    scopus 로고
    • ITRAQ underestimation in simple and complex mixtures: "the good, the bad and the ugly"
    • Ow, S. Y.; Salim, M.; Noirel, J.; Evans, C.; Rehman, I.; Wright, P. C. iTRAQ underestimation in simple and complex mixtures: "The good, the bad and the ugly" J. Proteome Res. 2009, 8 (11) 5347-5355
    • (2009) J. Proteome Res. , vol.8 , Issue.11 , pp. 5347-5355
    • Ow, S.Y.1    Salim, M.2    Noirel, J.3    Evans, C.4    Rehman, I.5    Wright, P.C.6
  • 52
    • 84870937033 scopus 로고    scopus 로고
    • R Development Core Team. R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing: Vienna, Austria
    • R Development Core Team. R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing: Vienna, Austria, 2011.
    • (2011)
  • 54
    • 0030660581 scopus 로고    scopus 로고
    • A genomic perspective on protein families
    • Tatusov, R. L.; Koonin, E. V.; Lipman, D. J. A genomic perspective on protein families Science 1997, 278 (5338) 631-637
    • (1997) Science , vol.278 , Issue.5338 , pp. 631-637
    • Tatusov, R.L.1    Koonin, E.V.2    Lipman, D.J.3
  • 55
    • 79956270174 scopus 로고    scopus 로고
    • Minimising iTRAQ ratio compression through understanding LC-MS elution dependence and high-resolution HILIC fractionation
    • Ow, S. Y.; Salim, M.; Noirel, J.; Evans, C.; Wright, P. C. Minimising iTRAQ ratio compression through understanding LC-MS elution dependence and high-resolution HILIC fractionation Proteomics 2011, 11 (11) 2341-2346
    • (2011) Proteomics , vol.11 , Issue.11 , pp. 2341-2346
    • Ow, S.Y.1    Salim, M.2    Noirel, J.3    Evans, C.4    Wright, P.C.5
  • 58
    • 8844234874 scopus 로고    scopus 로고
    • The transcriptional program of synchronous gametogenesis in Chlamydomonas reinhardtii
    • Abe, J.; Kubo, T.; Takagi, Y.; Saito, T.; Miura, K.; Fukuzawa, H.; Matsuda, Y. The transcriptional program of synchronous gametogenesis in Chlamydomonas reinhardtii Curr. Genet. 2004, 46 (5) 304-315
    • (2004) Curr. Genet. , vol.46 , Issue.5 , pp. 304-315
    • Abe, J.1    Kubo, T.2    Takagi, Y.3    Saito, T.4    Miura, K.5    Fukuzawa, H.6    Matsuda, Y.7
  • 59
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa, M.; Goto, S. KEGG: kyoto encyclopedia of genes and genomes Nucleic Acids Res. 2000, 28 (1) 27-30
    • (2000) Nucleic Acids Res. , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 60
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • Kanehisa, M.; Goto, S.; Sato, Y.; Furumichi, M.; Tanabe, M. KEGG for integration and interpretation of large-scale molecular data sets Nucleic Acids Res. 2012, 40 (D1) D109-D114
    • (2012) Nucleic Acids Res. , vol.40 , Issue.1 D
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4    Tanabe, M.5


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