Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: Application to a neuroinflammation rat model

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 10, 2012, Pages 3049-3059

  Ayciriex, Sophie ^a   Regazzetti, Anne ^a   Gaudin, Mathieu ^a,b,c,f   Prost, Elise ^d   Dargère, Delphine ^a   Massicot, France ^a   Auzeil, Nicolas ^a   Laprévote, Olivier ^a,e  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL LARIBOISIÈRE   (France)

^f Faculty of Medicine   (United Kingdom)

Author keywords

Cholesterol; Derivatization; Oxysterols; Quantification; UPLC ESI HRMS

Indexed keywords

ALKALINE CONDITIONS; ANALYTES; BIOLOGICAL SAMPLES; CONCENTRATION CHANGE; DERIVATIZATIONS; FOOD AND DRUG ADMINISTRATION; HIGH SENSITIVITY; LIMITS OF QUANTIFICATION; LIPOPOLYSACCHARIDES; MASS ANALYSIS; MASS SPECTROMETRY ANALYSIS; NANOMOLAR RANGE; NEUROINFLAMMATION; OXYSTEROLS; PATHOLOGICAL CONDITIONS; QUANTIFICATION; RAT MODEL; ROBUST ANALYTICAL METHODS; SIDE-CHAINS; UPLC/ESI/HRMS;

ALCOHOLS; ALKALINITY; CHOLESTEROL; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

LIPIDS;

CARBAMIC ACID DERIVATIVE; LIPOPOLYSACCHARIDE; STEROL;

ANIMAL; ARTICLE; BRAIN; BRAIN LEVEL; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; INFLAMMATION; METHODOLOGY; RAT; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY; WISTAR RAT;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CARBAMATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INFLAMMATION; LIPOPOLYSACCHARIDES; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEROLS;

ANIMALIA; MUS; RATTUS;

EID: 84870866676     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6396-6     Document Type: Article

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